Immune mechanisms and predictive biomarkers related to neoadjuvant immunotherapy response in stage III melanoma

Autor: Amanda Braga Figueiredo, Milton José Barros e Silva, Guilherme Ferreira de Britto Evangelista, Nayane Alves de Lima Galdino, Larissa de Melo Kuil, Iasmim Polido Santos, Kátia Luciano Pereira Morais, Clara Maciel Cavalcanti, Luciana Facure Moredo, João Pedreira Duprat-Neto, Kenneth J Gollob

Publikováno v: Heliyon, Vol 10, Iss 12, Pp e32624- (2024)

The treatment for stage III melanoma has advanced significantly, nevertheless, a substantial proportion of patients experience relapse. Neoadjuvant immune checkpoint blockade has emerged as a promising approach, allowing early micrometastatic disease

Externí odkaz: https://doaj.org/article/e8156cfed6ac4ff7b8cedd9f63a2d4e5

Leishmania metacyclogenesis is promoted in the absence of purines.

Autor: Tiago Donatelli Serafim, Amanda Braga Figueiredo, Pedro Augusto Carvalho Costa, Eduardo Almeida Marques-da-Silva, Ricardo Gonçalves, Sandra Aparecida Lima de Moura, Nelder Figueiredo Gontijo, Sydnei Magno da Silva, Marilene Suzan Marques Michalick, José Roberto Meyer-Fernandes, Roberto Paes de Carvalho, Silvia Reni Bortolin Uliana, Juliana Lopes Rangel Fietto, Luís Carlos Crocco Afonso

Publikováno v: PLoS Neglected Tropical Diseases, Vol 6, Iss 9, p e1833 (2012)

Leishmania parasites, the causative agent of leishmaniasis, are transmitted through the bite of an infected sand fly. Leishmania parasites present two basic forms known as promastigote and amastigote which, respectively, parasitizes the vector and th

Externí odkaz: https://doaj.org/article/5806430d98d24e3e98e9ff43318daddb

Balancing the good and the bad: controlling immune-related adverse events versus anti-tumor responses in cancer patients treated with immune checkpoint inhibitors

Autor: Guilherme Ferreira de Britto Evangelista, Amanda Braga Figueiredo, Milton José de Barros e Silva, Kenneth J Gollob

Publikováno v: Immunotherapy Advances. 2

Immune checkpoint inhibitors (ICI) have provided new hope for cancer patients, and in particular for patients with tumors that are immunologically active and classified as hot tumors. These tumors express antigenic and tumor microenvironment (TME) ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaead1869e8d8b990fbae5a2d15bb5fe
https://doi.org/10.1093/immadv/ltac008

Clustering of adenosine A

Autor: Amanda Braga, Figueiredo, Renata Alves, de Oliveira E Castro, Nívia Carolina, Nogueira-Paiva, Filipa, Moreira, Francisco Queiroz, Gonçalves, Rodrigo Pedro, Soares, William, Castro-Borges, Gustavo Gonçalves, Silva, Rodrigo Antunes, Cunha, Teresa, Gonçalves, Luís Carlos Crocco, Afonso

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 35(5)

Extracellular adenosine plays important roles in modulating the immune responses. We have previously demonstrated that infection of dendritic cells (DC) by Leishmania amazonensis leads to increased expression of CD39 and CD73 and to the selective act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::903a66a54032e4756930126834a02acf
https://pubmed.ncbi.nlm.nih.gov/33813781

Leishmania amazonensis-induced caMP triggered by adenosine a2B receptor is important to inhibit dendritic cell activation and evade immune response in infected mice

Autor: Luís Carlos Crocco Afonso, Míriam Conceição Souza-Testasicca, Tiago W. P. Mineo, Amanda Braga Figueiredo

Publikováno v: Repositório Institucional da UFOP
Universidade Federal de Ouro Preto (UFOP)
instacron:UFOP
Frontiers in Immunology
Frontiers in Immunology, Vol 8 (2017)

Differently from others Leishmania species, infection by the protozoan parasite L. amazonensis is associated with a lack of antigen-specific T-cell responses. Dendritic cells (DC) are essential for the innate immune response and for directing the dif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662782ae24b85ad379b8a90b6707c0c6
http://www.repositorio.ufop.br/handle/123456789/9897