CDC25B Inhibition by Menadione: A Potential New Therapeutical Approach

Autor: Carla de Castro Sant’ Anna, Helem Ferreira Ribeiro, Valdenira de Jesus Oliveira Kato, Rafael Maia de Sousa Brasil, Amanda Braga Bona, Danielle Feio da Costa, Isamu Komatsu Lima, Paulo Cardoso Soares, Ana Paula Araújo Guimarães, Paulo Pimentel de Assumpção, Rommel Rodriguez Burbano

Publikováno v: Anti-Cancer Agents in Medicinal Chemistry. 22:2927-2932

Abstract: Gastric cancer (GC) is the fifth most common type of tumor and the third leading cause of cancer death worldwide. The evolution of gastric carcinogenesis is still poorly understood and, for this reason, preclinical research protocols were e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7d9ba9edde2bce693a13c2be1ded534
https://doi.org/10.2174/1871520622666220418131935

Expression of hsa-miR-9 and MYC Copy Number Variation in Hereditary Diffuse Gastric Cancer

Autor: Kelly Cristina da Silva Oliveira, Leticia Martins Lamarão, Diego Di Felipe Avila Alcantara, Paulo Pimentel Assumpção, Amanda Braga Bona, Caroline Aquino Moreira-Nunes, Thayanne Macedo Pinheiro, Danielle Queiroz Calcagno, Fernanda Jardim Da Silva, Rommel Rodríguez Burbano

Publikováno v: Anticancer Research. 37:2401-2406

BACKGROUND/AIM Approximately, 15-50% of families affected by hereditary diffuse gastric cancer (HDGC) exhibit CDH1 germline mutations. CDH1 gene encodes E-cadherin, protein essential to the cell-cell contact of gastric epithelium. Studies have shown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::66d2e49550ffb09e5e98c03551211cae
https://doi.org/10.21873/anticanres.11579

Menadione reduces CDC25B expression and promotes tumor shrinkage in gastric cancer

Autor: Juan Antonio Rey Herranz, Antonio Carlos Cunha Lacreta Junior, Carlos Alberto Machado da Rocha, Helem Ferreira Ribeiro, Paulo Pimentel Assumpção, Danielle Queiroz Calcagno, José Muñiz, Giovanny R. Pinto, Amanda Braga Bona, Rommel Mario Rodriguez Burbano

Publikováno v: Therapeutic Advances in Gastroenterology. 13:175628481989543

Background: Gastric cancer is one of the most incident types of cancer worldwide and presents high mortality rates and poor prognosis. MYC oncogene overexpression is a key event in gastric carcinogenesis and it is known that its protein positively re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2525d8dd9961e7527743675d8cdd77b6
https://doi.org/10.1177/1756284819895435

Genetic screening analysis of patients with hereditary diffuse gastric cancer from northern and northeastern Brazil

Autor: Rommel Rodríguez Burbano, Giovanny R. Pinto, Paulo Pimentel Assumpção, Leticia Martins Lamarão, Amanda Braga Bona, Bárbara do Nascimento Borges, Mariceli Baia Leão Barros, Caroline Aquino Moreira-Nunes, Juan A. Rey, Raquel Carvalho Montenegro, Helem Ferreira Ribeiro

Publikováno v: Hereditary Cancer in Clinical Practice
Repositório Institucional da Universidade Federal do Ceará (UFC)
Universidade Federal do Ceará (UFC)
instacron:UFC

Background: Hereditary diffuse gastric cancer (HDGC) is a hereditary autosomal inherited syndrome associated with CDH1 germline mutations. In Brazil, gastrointestinal tumors are among the most prevalent tumor types and constitute a serious public hea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ace4beaab00b779e670203d30a37382c
http://europepmc.org/articles/PMC4150117