Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Amanda Baines"'
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-17 (2022)
Abstract Background Fluticasone furoate/vilanterol trifenatate (FF/VI) is an inhaled therapy for the treatment of asthma, with a prolonged duration of anti-inflammatory and bronchodilatory action. This study investigated the global metabolomic and li
Externí odkaz:
https://doaj.org/article/786ff62ea9734385aa3f3a97e8893455
Autor:
George Bardsley, Peter Daley-Yates, Amanda Baines, Rodger Kempsford, Mathew Williams, Tony Mallon, Irene Braithwaite, Kylie Riddell, Shashidhar Joshi, Philippe Bareille, Richard Beasley, James Fingleton, on behalf of the study team
Publikováno v:
Respiratory Research, Vol 19, Iss 1, Pp 1-11 (2018)
Abstract Background Fluticasone furoate/Vilanterol trifenatate (FF/VI) is an inhaled corticosteroid/long-acting beta-agonist combination with a prolonged bronchodilator duration of action. We characterised the time-course of onset and offset of airwa
Externí odkaz:
https://doaj.org/article/0ea8d756e76c4259b19588bbbb114934
Autor:
James Fingleton, Richard Beasley, Amanda Baines, Peter T. Daley-Yates, George Bardsley, Kylie Riddell, Shashidhar Joshi, Philippe Bareille
Publikováno v:
60. Kongress der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e. V..
Autor:
David Prime, Jackie Moynihan, Andrew Preece, Wilfried De Backer, Noushin Brealey, Anthony Cahn, Dennis Kelleher, Melanie Hamilton, Alison Moore, Amanda Baines
Publikováno v:
Journal of Aerosol Medicine and Pulmonary Drug Delivery
Journal of aerosol medicine and pulmonary drug delivery
Journal of aerosol medicine and pulmonary drug delivery
Background: Two studies were undertaken to characterize the maximal effort inhalation profiles of healthy subjects and patients with asthma or chronic obstructive pulmonary disease (COPD) through a moderate-resistance dry powder inhaler (DPI). Correl
Autor:
Mark D. Minden, Amanda Baines, Terrence Bradley, Sameem Abedin, Justin M. Watts, Amber Thomassen, Olena Barbash, Shelby A. Gorman, Brandon E. Kremer, Andrew M. Brunner, Nikolaos Papadantonakis, Gautam Borthakur
Publikováno v:
Blood. 134:2656-2656
Background Protein arginine methyltransferase 5 (PRMT5) is the primary enzyme responsible for symmetric arginine dimethylation of multiple proteins that impact cell proliferation. Its substrates include proteins involved in mRNA splicing, signal tran
Autor:
Shashidhar Joshi, Kylie Riddell, Richard Beasley, George Bardsley, Amanda Baines, Philippe Bareille, James Fingleton, Peter T. Daley-Yates
Publikováno v:
Airway Pharmacology and Treatment.
FF is an inhaled corticosteroid (ICS) with higher glucocorticoid receptor (GR) affinity and greater lung retention compared to other ICS. We investigated whether these attributes confer a prolonged duration of anti-inflammatory action. This was a ran
Autor:
Amanda Baines, Robert Lai, M. Kelly, J. Green, A. Krishen, Thor Ostenfeld, Praveen Anand, Jonathan Bullman
Publikováno v:
European Journal of Pain. 17:844-857
Background Inhibitors of p38 mitogen-activated protein kinase are undergoing evaluation as a novel class of anti-rheumatic drugs, by virtue of their ability to suppress the production of pro-inflammatory cytokines. Emerging data suggests that they ma
Clinical trial of the p38 MAP kinase inhibitor dilmapimod in neuropathic pain following nerve injury
Autor:
Thor Ostenfeld, Boris A. Chizh, Jonathan Robertson, Nick P. Bird, Robert Lai, Amanda Baines, Joanne Palmer, Ravikiran Shenoy, Praveen Anand
Publikováno v:
European journal of pain (London, England). 15(10)
Current treatments of neuropathic pain arising from conditions such as nerve injury/compression are only partially effective, and limited in their use by side-effects. p38 mitogen-activated protein kinase (MAPK) is involved in the regulation and synt
Autor:
Antonella Napolitano, Jonathan Bullman, F. Guillard, Joanne Palmer, Boris A. Chizh, Amanda Baines, Jonathan Appleby, Robert Lai
Publikováno v:
European Journal of Pain. 13
Publikováno v:
European Journal of Pain. 13