Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Amanda B Parrish"'
Autor:
Misty Gravelin, Joan E. Adamo, Sharon Ellison, Erika Segear, Amanda B. Parrish, Christine Deeter, Jennifer Hamill, Laurie Rigan, George A. Mashour, Kevin J. Weatherwax
Publikováno v:
Journal of Clinical and Translational Science, Vol 7 (2023)
Expanded access (EA) provides a pathway for the clinical use of investigational products (drugs, biologics, and medical devices) for patients who are without satisfactory therapeutic options and for whom a clinical trial is not available. Academic me
Externí odkaz:
https://doaj.org/article/0f8891b01794433285895cb2b0fb2ca8
Autor:
Kimberly A. Brownley, Marie Rape, Amanda Wood, Gaurav Dave, Chad Henderson, Diana Severynse-Stevens, Mike Zmuda, Diane Earp, Carmella Moody, Issis Kelly-Pumarol, Joseph Andrews, Kristen M. Foss, Stephanie Fraser, Erika Segear, Amanda B. Parrish
Publikováno v:
Journal of Clinical and Translational Science, Vol 5 (2021)
Availability of trained professionals to assist researchers navigating regulatory pathways for new drug and device development is limited within academic institutions. We created ReGARDD (Regulatory Guidance for Academic Research of Drugs and Devices
Externí odkaz:
https://doaj.org/article/6c525cc4c2a047cfb4a5a506258415f6
Autor:
Misty Gravelin, Joan E. Adamo, Sharon Ellison, Erika Segear, Amanda B. Parrish, Christine Deeter, Jennifer Hamill, Laurie Rigan, George A. Mashour, Kevin J. Weatherwax
Publikováno v:
Journal of Clinical and Translational Science. 7
Expanded access (EA) provides a pathway for the clinical use of investigational products (drugs, biologics, and medical devices) for patients who are without satisfactory therapeutic options and for whom a clinical trial is not available. Academic me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f3668d0759c57698b9ee8bf2d58ca07
https://doi.org/10.1017/cts.2022.494
https://doi.org/10.1017/cts.2022.494
Autor:
Armando D Bedoya, Nicoleta J Economou-Zavlanos, Benjamin A Goldstein, Allison Young, J Eric Jelovsek, Cara O’Brien, Amanda B Parrish, Scott Elengold, Kay Lytle, Suresh Balu, Erich Huang, Eric G Poon, Michael J Pencina
Publikováno v:
J Am Med Inform Assoc
Artificial intelligence/machine learning models are being rapidly developed and used in clinical practice. However, many models are deployed without a clear understanding of clinical or operational impact and frequently lack monitoring plans that can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::438c8c469f1e055e33656acaceda8a98
https://pubmed.ncbi.nlm.nih.gov/35641123
https://pubmed.ncbi.nlm.nih.gov/35641123
Autor:
Diana Severynse-Stevens, Kristen M. Foss, Gaurav Dave, Diane Earp, Issis Kelly-Pumarol, Amanda Wood, Erika Segear, Stephanie Fraser, Mike Zmuda, Joseph E. Andrews, Kimberly A Brownley, Amanda B. Parrish, Chad Henderson, Carmella Moody, Marie Rape
Publikováno v:
Journal of Clinical and Translational Science
Availability of trained professionals to assist researchers navigating regulatory pathways for new drug and device development is limited within academic institutions. We created ReGARDD (Regulatory Guidance for Academic Research of Drugs and Devices
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f1d6c0b7b1c83e5edb5b4e4ca6a0eb4
https://doi.org/10.1017/cts.2021.3
https://doi.org/10.1017/cts.2021.3
Autor:
Joanne Kurtzberg, Kevin Shoulars, Jesse D. Troy, Lynn Cheatham, Amanda B. Parrish, Kristin Page, Pamela Noldner, Andrew E. Balber, Tracy Gentry
Publikováno v:
Blood. 127:2346-2354
Banked, unrelated umbilical cord blood provides access to hematopoietic stem cell transplantation for patients lacking matched bone marrow donors, yet 10% to 15% of patients experience graft failure or delayed engraftment. This may be due, at least i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec91af10be33f1c640dfa3511553f1ce
https://doi.org/10.1182/blood-2015-08-666990
https://doi.org/10.1182/blood-2015-08-666990
Autor:
Erin K. O'Reilly, Amanda B. Parrish, Susan Natoli, Nancy Hassell, Jelena P. Berglund, Irwin M. Liu, Denise C. Snyder, Mark Stacy, Valerie Amspacher, Bruce K. Burnett, Jackie B. Rimmler
Publikováno v:
Clinical and Translational Science. 8:48-51
The Food and Drug Administration Amendments Act of 2007 (FDAAA 2007, US Public Law 110-98) mandated registration and reporting of results for applicable clinical trials (ACTs). Meeting these registration and results reporting requirements has proven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b46333ba107c68af67fc0cdb5f2ed304
https://doi.org/10.1111/cts.12235
https://doi.org/10.1111/cts.12235
Autor:
Joshua L. Andersen, Kenkyo Matsuura, Carrie E. Johnson, Jiyeon Kim, Manabu Kurokawa, Sally Kornbluth, Amanda B. Parrish, Christopher D. Freel
Publikováno v:
The EMBO Journal. 31:1279-1292
Many pro-apoptotic signals trigger mitochondrial cytochrome c release, leading to caspase activation and ultimate cellular breakdown. Cell survival pathways, including the mitogen-activated protein kinase (MAPK) cascade, promote cell viability by imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5abb550cece185418244a111cfde16e7
https://doi.org/10.1038/emboj.2011.491
https://doi.org/10.1038/emboj.2011.491
Autor:
Carrie E. Johnson, Qian Zhang, Michelle I. Smith, Sally Kornbluth, Terry Van Dyke, Amanda B. Parrish, Robert J. Wechsler-Reya, Allyson E. Vaughn, Kevin M. Wright, Yolanda Y. Huang, Mohanish Deshmukh
Publikováno v:
Proceedings of the National Academy of Sciences. 104:20820-20825
Brain tumors are typically resistant to conventional chemotherapeutics, most of which initiate apoptosis upstream of mitochondrial cytochrome c release. In this study, we demonstrate that directly activating apoptosis downstream of the mitochondria,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e6a7a678bec9fb1e79c67101d5eb2a
https://doi.org/10.1073/pnas.0709101105
https://doi.org/10.1073/pnas.0709101105
Autor:
Jeffrey R. Marks, Zachary T. Schafer, Kevin M. Wright, Amanda B. Parrish, Mohanish Deshmukh, Seth S. Margolis, Sally Kornbluth
Publikováno v:
Cancer Research. 66:2210-2218
Apoptotic signaling defects both promote tumorigenesis and confound chemotherapy. Typically, chemotherapeutics stimulate cytochrome c release to the cytoplasm, thereby activating the apoptosome. Although cancer cells can be refractory to cytochrome c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f142f6d7fae29634cf3674748ea1da1
https://doi.org/10.1158/0008-5472.can-05-3923
https://doi.org/10.1158/0008-5472.can-05-3923