Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Amanda B Muir"'
Autor:
Melanie A Ruffner, Zhe Zhang, Kelly Maurer, Amanda B Muir, Antonella Cianferoni, Kathleen E Sullivan, Jonathan M Spergel
Publikováno v:
Clinical & Translational Immunology, Vol 10, Iss 7, Pp n/a-n/a (2021)
Abstract Objective There are no disease‐modifying therapies for the treatment of eosinophilic oesophagitis (EoE), which is driven by non‐IgE‐mediated allergic inflammation. A recent clinical trial of milk epicutaneous immunotherapy (EPIT) has s
Externí odkaz:
https://doaj.org/article/5641dcfa155e4a82a471ee193b1615ad
Autor:
Khvaramze Shaverdashvili, Jennie Padlo, Daniel Weinblatt, Yang Jia, Wenpeng Jiang, Divya Rao, Dorottya Laczkó, Kelly A Whelan, John P Lynch, Amanda B Muir, Jonathan P Katz
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0215746 (2019)
Understanding the regulatory mechanisms within esophageal epithelia is essential to gain insight into the pathogenesis of esophageal diseases, which are among the leading causes of morbidity and mortality throughout the world. The zinc-finger transcr
Externí odkaz:
https://doaj.org/article/eeaae1ba61d94098aacc5db5128931ff
Autor:
Prasanna M Chandramouleeswaran, Dawen Shen, Anna J Lee, Alain Benitez, Kara Dods, Fiona Gambanga, Benjamin J Wilkins, Jamie Merves, Yuliana Noah, Sarit Toltzis, Jennifer H Yearley, Jonathan M Spergel, Hiroshi Nakagawa, Rene deWaal Malefyt, Amanda B Muir, Mei-Lun Wang
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150968 (2016)
Eosinophilic esophagitis (EoE) is a chronic Th2 and food antigen-mediated disease characterized by esophageal eosinophilic infiltration. Thymic stromal lymphopoetin (TSLP), an epithelial derived cytokine which bridges innate and Th2-type adaptive imm
Externí odkaz:
https://doaj.org/article/88cce7a59bc84cd98ad546ff305a0cdb
Autor:
Masaru Sasaki, Takeo Hara, Joshua X. Wang, Yusen Zhou, Kanak V. Kennedy, Chizoba N. Umeweni, Maiya A. Alston, Zachary C. Spergel, Satoshi Ishikawa, Ryugo Teranishi, Ritsu Nakagawa, Emily A. Mcmillan, Kelly A. Whelan, Tatiana A. Karakasheva, Kathryn E. Hamilton, Melanie A. Ruffner, Amanda B. Muir
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 6, Pp 923-937 (2024)
Background & Aims: Epithelial disruption in eosinophilic esophagitis (EoE) encompasses both impaired differentiation and diminished barrier integrity. We have shown that lysyl oxidase (LOX), a collagen cross-linking enzyme, is up-regulated in the eso
Externí odkaz:
https://doaj.org/article/4642d52f7d81435797854e2d8c616673
Autor:
Alena Klochkova, Adam L. Karami, Annie D. Fuller, Louis R. Parham, Surali R. Panchani, Shruthi Natarajan, Jazmyne L. Jackson, Anbin Mu, Yinfei Tan, Kathy Q. Cai, Andres J. Klein-Szanto, Amanda B. Muir, Marie-Pier Tétreault, Xavier Graña, Kathryn E. Hamilton, Kelly A. Whelan
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 1, Pp 15-40 (2024)
Background & Aims: Autophagy plays roles in esophageal pathologies both benign and malignant. Here, we aim to define the role of autophagy in esophageal epithelial homeostasis. Methods: We generated tamoxifen-inducible, squamous epithelial-specific A
Externí odkaz:
https://doaj.org/article/10798208ac324620b1299c8ac2877db4
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 5, Pp 713-718 (2024)
Eosinophilic esophagitis (EoE) is an emerging form of food allergy that exerts a significant clinical and financial burden worldwide. EoE is clinically characterized by eosinophil-rich inflammatory infiltrates in esophageal mucosa and esophageal dysf
Externí odkaz:
https://doaj.org/article/cb814a89b8054a00b4aee11f5b159408
Autor:
Jamie Merves, Prasanna Modayur Chandramouleeswaran, Alain J Benitez, Amanda B Muir, Anna J Lee, Diana M Lim, Kara Dods, Isha Mehta, Eduardo D Ruchelli, Hiroshi Nakagawa, Jonathan M Spergel, Mei-Lun Wang
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0114831 (2015)
Eosinophilic Esophagitis (EoE) is a chronic allergic disorder, whose pathobiology is incompletely understood. Histamine-producing cells including mast cells and basophils have been implicated in EoE. However, very little is currently known about the
Externí odkaz:
https://doaj.org/article/dc58926afe1642ebbd778831fbae6130
Autor:
Mirna Chehade, MD, MPH, Benjamin L. Wright, MD, Samantha Walsh, MLS, MA, Dominique D. Bailey, MD, Amanda B. Muir, MD, Amy D. Klion, MD, Margaret H. Collins, MD, Carla M. Davis, MD, Glenn T. Furuta, MD, Sandeep Gupta, MD, Paneez Khoury, MD, Kathryn A. Peterson, MD, Elizabeth T. Jensen, PhD
Publikováno v:
Journal of Allergy and Clinical Immunology: Global, Vol 3, Iss 3, Pp 100260- (2024)
Background: The demographic characteristics of patients with eosinophilic gastrointestinal diseases (EGIDs) are poorly understood. Population-based assessments of EGID demographics may indicate health disparities in diagnosis. Objectives: We aimed to
Externí odkaz:
https://doaj.org/article/1b5978b1272b4a1e8c778c55c02c4eb6
Autor:
David A. Hill, Amanda B. Muir
Publikováno v:
Frontiers in Allergy, Vol 4 (2023)
Externí odkaz:
https://doaj.org/article/9a9b025fe4af41158bcd14108a5ba5f4
Autor:
Tatiana A. Karakasheva, Yusen Zhou, Hongbo M. Xie, Gloria E. Soto, Tiana D. Johnson, Madison A. Stoltz, Daana M. Roach, Noor Nema, Chizoba N. Umeweni, Kaitlyn Naughton, Lauren Dolinsky, James A. Pippin, Andrew D. Wells, Struan F.A. Grant, Louis Ghanem, Natalie Terry, Amanda B. Muir, Kathryn E. Hamilton
Publikováno v:
Gastro Hep Advances, Vol 2, Iss 6, Pp 830-842 (2023)
Background and Aims: A key histopathological feature of inflammatory bowel disease is damage to the mucosa, including breakdown of the epithelial barrier. Human enteroids and colonoids are a critical bench-to-bedside tool for studying the epithelium
Externí odkaz:
https://doaj.org/article/3b5bbb61491c43eda5c548a0bbb7c298