Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Amanda B, Muir"'
Autor:
Kanak V. Kennedy, MD, Anna Costello, MD, Melissa A. Lerman, MD, PhD, Jon M. Burnham, MD, Aoife Corcoran, MD, Joseph Piccione, DO, Alexandra Grier, MD, PhD, Kathleen Sullivan, MD, PhD, Terri Whitehorn-Brown, MD, Caitlin J. Alexander, MD, Laura S. Finn, MD, Benjamin J. Wilkins, MD, PhD, Amanda B. Muir, MD
Publikováno v:
Journal of Allergy and Clinical Immunology: Global, Vol 3, Iss 4, Pp 100314- (2024)
We present the first case of a dupilumab-induced hyperinflammatory state in the setting of underlying eosinophilic esophagitis characterized by multisystem granulomatous inflammation. Although clinical trial data and subsequent real-world experience
Externí odkaz:
https://doaj.org/article/f5ab92898c3c4073816864d7097b9d16
Autor:
Mirna Chehade, MD, MPH, Benjamin L. Wright, MD, Samantha Walsh, MLS, MA, Dominique D. Bailey, MD, Amanda B. Muir, MD, Amy D. Klion, MD, Margaret H. Collins, MD, Carla M. Davis, MD, Glenn T. Furuta, MD, Sandeep Gupta, MD, Paneez Khoury, MD, Kathryn A. Peterson, MD, Elizabeth T. Jensen, PhD
Publikováno v:
Journal of Allergy and Clinical Immunology: Global, Vol 3, Iss 3, Pp 100260- (2024)
Background: The demographic characteristics of patients with eosinophilic gastrointestinal diseases (EGIDs) are poorly understood. Population-based assessments of EGID demographics may indicate health disparities in diagnosis. Objectives: We aimed to
Externí odkaz:
https://doaj.org/article/1b5978b1272b4a1e8c778c55c02c4eb6
Autor:
Masaru Sasaki, Takeo Hara, Joshua X. Wang, Yusen Zhou, Kanak V. Kennedy, Chizoba N. Umeweni, Maiya A. Alston, Zachary C. Spergel, Satoshi Ishikawa, Ryugo Teranishi, Ritsu Nakagawa, Emily A. Mcmillan, Kelly A. Whelan, Tatiana A. Karakasheva, Kathryn E. Hamilton, Melanie A. Ruffner, Amanda B. Muir
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 6, Pp 923-937 (2024)
Background & Aims: Epithelial disruption in eosinophilic esophagitis (EoE) encompasses both impaired differentiation and diminished barrier integrity. We have shown that lysyl oxidase (LOX), a collagen cross-linking enzyme, is up-regulated in the eso
Externí odkaz:
https://doaj.org/article/4642d52f7d81435797854e2d8c616673
Autor:
Alena Klochkova, Adam L. Karami, Annie D. Fuller, Louis R. Parham, Surali R. Panchani, Shruthi Natarajan, Jazmyne L. Jackson, Anbin Mu, Yinfei Tan, Kathy Q. Cai, Andres J. Klein-Szanto, Amanda B. Muir, Marie-Pier Tétreault, Xavier Graña, Kathryn E. Hamilton, Kelly A. Whelan
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 1, Pp 15-40 (2024)
Background & Aims: Autophagy plays roles in esophageal pathologies both benign and malignant. Here, we aim to define the role of autophagy in esophageal epithelial homeostasis. Methods: We generated tamoxifen-inducible, squamous epithelial-specific A
Externí odkaz:
https://doaj.org/article/10798208ac324620b1299c8ac2877db4
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 5, Pp 713-718 (2024)
Eosinophilic esophagitis (EoE) is an emerging form of food allergy that exerts a significant clinical and financial burden worldwide. EoE is clinically characterized by eosinophil-rich inflammatory infiltrates in esophageal mucosa and esophageal dysf
Externí odkaz:
https://doaj.org/article/cb814a89b8054a00b4aee11f5b159408
Autor:
Masataka Shimonosono, Masaki Morimoto, Wataru Hirose, Yasuto Tomita, Norihiro Matsuura, Samuel Flashner, Mesra S. Ebadi, Emilea H. Okayasu, Christian Y. Lee, William R. Britton, Cecilia Martin, Beverly R. Wuertz, Anuraag S. Parikh, Uma M. Sachdeva, Frank G. Ondrey, Venkatram R. Atigadda, Craig A. Elmets, Julian A. Abrams, Amanda B. Muir, Andres J. Klein-Szanto, Kenneth I. Weinberg, Fatemeh Momen-Heravi, Hiroshi Nakagawa
Publikováno v:
Biomolecules, Vol 14, Iss 9, p 1126 (2024)
Background: Esophageal organoids from a variety of pathologies including cancer are grown in Advanced Dulbecco’s Modified Eagle Medium-Nutrient Mixture F12 (hereafter ADF). However, the currently available ADF-based formulations are suboptimal for
Externí odkaz:
https://doaj.org/article/57eb300583f74f59b430dc92b6259518
Autor:
David A. Hill, Amanda B. Muir
Publikováno v:
Frontiers in Allergy, Vol 4 (2023)
Externí odkaz:
https://doaj.org/article/9a9b025fe4af41158bcd14108a5ba5f4
Autor:
Tatiana A. Karakasheva, Yusen Zhou, Hongbo M. Xie, Gloria E. Soto, Tiana D. Johnson, Madison A. Stoltz, Daana M. Roach, Noor Nema, Chizoba N. Umeweni, Kaitlyn Naughton, Lauren Dolinsky, James A. Pippin, Andrew D. Wells, Struan F.A. Grant, Louis Ghanem, Natalie Terry, Amanda B. Muir, Kathryn E. Hamilton
Publikováno v:
Gastro Hep Advances, Vol 2, Iss 6, Pp 830-842 (2023)
Background and Aims: A key histopathological feature of inflammatory bowel disease is damage to the mucosa, including breakdown of the epithelial barrier. Human enteroids and colonoids are a critical bench-to-bedside tool for studying the epithelium
Externí odkaz:
https://doaj.org/article/3b5bbb61491c43eda5c548a0bbb7c298
Autor:
Mohammad Faujul Kabir, Adam L. Karami, Ricardo Cruz-Acuña, Alena Klochkova, Reshu Saxena, Anbin Mu, Mary Grace Murray, Jasmine Cruz, Annie D. Fuller, Margarette H. Clevenger, Kumaraswamy Naidu Chitrala, Yinfei Tan, Kelsey Keith, Jozef Madzo, Hugh Huang, Jaroslav Jelinek, Tatiana Karakasheva, Kathryn E. Hamilton, Amanda B. Muir, Marie-Pier Tétreault, Kelly A. Whelan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The level of cellular diversity in the esophageal epithelium has yet to be classified at the single cell level. Here the authors analyze the transcriptome of 44,679 murine esophageal keratinocytes to identify an unexpected level of cellular heterogen
Externí odkaz:
https://doaj.org/article/08d60dfa06354f1792c694cb232b3b9d
Autor:
Takeo Hara, Yuta Kasagi, Joshua Wang, Masaru Sasaki, Bailey Aaron, Adam Karami, Masataka Shimonosono, Rieko Shimonosono, Hisatsugu Maekawa, Lauren Dolinsky, Benjamin Wilkins, Jeremy Klein, Jane Wei, Kathryn Nunes, Kristle Lynch, Jonathan M. Spergel, Kathryn E. Hamilton, Melanie A. Ruffner, Tatiana A. Karakasheva, Kelly A. Whelan, Hiroshi Nakagawa, Amanda B. Muir
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 5, Pp 1449-1467 (2022)
Background & Aims: Although basal cell hyperplasia is a histologic hallmark of eosinophilic esophagitis (EoE), little is known about the capabilities of epithelial renewal and differentiation in the EoE inflammatory milieu. In murine esophageal epith
Externí odkaz:
https://doaj.org/article/6cf51597b7804a5da4a9fd173aba4b20