Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Amanda A. Riley"'
Publikováno v:
EJNMMI Physics, Vol 3, Iss 1, Pp 1-8 (2016)
Abstract Recent advancements in PET instrumentation have made the non-invasive assessment of cardiovascular function in small animals a reality. The majority of small animal PET systems use stationary detector gantries, thus affording high temporal r
Externí odkaz:
https://doaj.org/article/7c2d860b2eec485bae42a0335a93fc1d
Autor:
Amanda K. Riley, Michael Grant, Aidan Snell, Elizabeth Cromwell, Athea Vichas, Sitapriya Moorthi, Callie Rominger, Shrikar P. Modukuri, Anatoly Urisman, Pau Castel, Lixin Wan, Alice H. Berger
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110499- (2024)
Summary: RIT1 is a rare and understudied oncogene in lung cancer. Despite structural similarity to other RAS GTPase proteins such as KRAS, oncogenic RIT1 activity does not appear to be tightly regulated by nucleotide exchange or hydrolysis. Instead,
Externí odkaz:
https://doaj.org/article/80139380a31c425ebc93373b402148ab
Autor:
Amanda K. Riley, Alice H. Berger
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 6 (2021)
In recent work, we performed CRISPR/Cas9 screening in RIT1 (Ras-like in all tissues)-mutant cancer cells. We found that RIT1-mutant cells are vulnerable to loss of mitotic regulators, and mutant RIT1 synergizes with YAP1 (yes-associated protein 1) in
Externí odkaz:
https://doaj.org/article/3488c6b845a04380a4140fe073232125
Autor:
David P. Kodack, Anna F. Farago, Anahita Dastur, Matthew A. Held, Leila Dardaei, Luc Friboulet, Friedrich von Flotow, Leah J. Damon, Dana Lee, Melissa Parks, Richard Dicecca, Max Greenberg, Krystina E. Kattermann, Amanda K. Riley, Florian J. Fintelmann, Coleen Rizzo, Zofia Piotrowska, Alice T. Shaw, Justin F. Gainor, Lecia V. Sequist, Matthew J. Niederst, Jeffrey A. Engelman, Cyril H. Benes
Publikováno v:
Cell Reports, Vol 21, Iss 11, Pp 3298-3309 (2017)
Personalized cancer therapy is based on a patient’s tumor lineage, histopathology, expression analyses, and/or tumor DNA or RNA analysis. Here, we aim to develop an in vitro functional assay of a patient’s living cancer cells that could complemen
Externí odkaz:
https://doaj.org/article/016db17b42214179a6109aad4764e0a1
Autor:
Alice T. Shaw, Aaron N. Hata, Ted W. Johnson, Jeffrey A. Engelman, Mari Mino-Kenudson, Jochen K. Lennerz, Cyril H. Benes, A. John Iafrate, Rebecca S. Heist, Daria Timonina, Krystina E. Kattermann, Amanda K. Riley, Lorin A. Ferris, Justin F. Gainor, Harper Hubbeling, Sergei Timofeevski, Ibiayi Dagogo-Jack, Kylie Prutisto-Chang, Leila Dardaei, Adam Langenbucher, Luc Friboulet, Benjamin J. Burke, Michael S. Lawrence, Jessica J. Lin, Satoshi Yoda
suppl tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695e64cddb17425642cdd97e3a2d9049
https://doi.org/10.1158/2159-8290.22532569
https://doi.org/10.1158/2159-8290.22532569
Autor:
Alice T. Shaw, Aaron N. Hata, Ted W. Johnson, Jeffrey A. Engelman, Mari Mino-Kenudson, Jochen K. Lennerz, Cyril H. Benes, A. John Iafrate, Rebecca S. Heist, Daria Timonina, Krystina E. Kattermann, Amanda K. Riley, Lorin A. Ferris, Justin F. Gainor, Harper Hubbeling, Sergei Timofeevski, Ibiayi Dagogo-Jack, Kylie Prutisto-Chang, Leila Dardaei, Adam Langenbucher, Luc Friboulet, Benjamin J. Burke, Michael S. Lawrence, Jessica J. Lin, Satoshi Yoda
Supplementary Methods include Enzyme Kinetic Assays and Computational Methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c2a51cb420c3360802ceddf3bd3129
https://doi.org/10.1158/2159-8290.22532572
https://doi.org/10.1158/2159-8290.22532572
Autor:
Lecia V. Sequist, Aaron N. Hata, Beni Wolf, Sai-Hong I. Ou, Corinne Clifford, Erica K. Evans, Alice T. Shaw, Rebecca S. Heist, A. John Iafrate, Mari Mino-Kenudson, Dora Dias-Santagata, Richard B. Lanman, Rebecca J. Nagy, Jessica J. Lin, Varuna Nangia, Amanda K. Riley, Satoshi Yoda, Wenjia Su, Subba R. Digumarthy, Mandeep K. Banwait, Nicolas Marcoux, Viola W. Zhu, Inga T. Lennes, Justin F. Gainor, Jochen K. Lennerz, Hideko Isozaki, Zofia Piotrowska
Supplementary Data and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc96358440634edc76f9afcf0d045e29
https://doi.org/10.1158/2159-8290.22534325.v1
https://doi.org/10.1158/2159-8290.22534325.v1
Autor:
Alice T. Shaw, Aaron N. Hata, Ted W. Johnson, Jeffrey A. Engelman, Mari Mino-Kenudson, Jochen K. Lennerz, Cyril H. Benes, A. John Iafrate, Rebecca S. Heist, Daria Timonina, Krystina E. Kattermann, Amanda K. Riley, Lorin A. Ferris, Justin F. Gainor, Harper Hubbeling, Sergei Timofeevski, Ibiayi Dagogo-Jack, Kylie Prutisto-Chang, Leila Dardaei, Adam Langenbucher, Luc Friboulet, Benjamin J. Burke, Michael S. Lawrence, Jessica J. Lin, Satoshi Yoda
Supplementary Figures include Figure S1-S9.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41fad9679c55dabdcc8b3f00fc268e3f
https://doi.org/10.1158/2159-8290.22532575
https://doi.org/10.1158/2159-8290.22532575
Autor:
Lecia V. Sequist, Aaron N. Hata, Beni Wolf, Sai-Hong I. Ou, Corinne Clifford, Erica K. Evans, Alice T. Shaw, Rebecca S. Heist, A. John Iafrate, Mari Mino-Kenudson, Dora Dias-Santagata, Richard B. Lanman, Rebecca J. Nagy, Jessica J. Lin, Varuna Nangia, Amanda K. Riley, Satoshi Yoda, Wenjia Su, Subba R. Digumarthy, Mandeep K. Banwait, Nicolas Marcoux, Viola W. Zhu, Inga T. Lennes, Justin F. Gainor, Jochen K. Lennerz, Hideko Isozaki, Zofia Piotrowska
Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e051601bd88ba6af4840dc715298fa
https://doi.org/10.1158/2159-8290.22534322.v1
https://doi.org/10.1158/2159-8290.22534322.v1
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
Autor:
Natasha Rekhtman, Athea Vichas, Robert K. Bradley, Jacqueline Watson, John K. Lee, Austin M. Gabel, Marina K. Baine, Amanda K. Riley, Shriya Kamlapurkar, Federica Piccioni, James D. Thomas, Iris Fung, Naomi T. Nkinsi, Emily M. Hatch, Jennifer Chen, Marc Ladanyi, Matthew G. Rees, Fujiko Duke, April Lo, Phoebe C. R. Parrish, Alice H. Berger
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature Communications
CRISPR-based cancer dependency maps are accelerating advances in cancer precision medicine, but adequate functional maps are limited to the most common oncogenes. To identify opportunities for therapeutic intervention in other rarer subsets of cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13965f9f552d8b88b893eeabc031c85b
https://doaj.org/article/06e749d7f425413a87006cc1366f2c04
https://doaj.org/article/06e749d7f425413a87006cc1366f2c04