Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Amanda A. Bouffard"'
Autor:
Rebecca C. Larson, Michael C. Kann, Charlotte Graham, Christopher W. Mount, Ana P. Castano, Won-Ho Lee, Amanda A. Bouffard, Hana N. Takei, Antonio J. Almazan, Irene Scarfó, Trisha R. Berger, Andrea Schmidts, Matthew J. Frigault, Kathleen M. E. Gallagher, Marcela V. Maus
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Chimeric Antigen Receptor (CAR) T cells directed to B cell maturation antigen (BCMA) mediate profound responses in patients with multiple myeloma, but most patients do not achieve long-term complete remissions. In addition, recent evidence s
Externí odkaz:
https://doaj.org/article/008a498ec868469ca7437a0db7630ab9
Autor:
Andrea Schmidts, Maria Ormhøj, Bryan D. Choi, Allison O. Taylor, Amanda A. Bouffard, Irene Scarfò, Rebecca C. Larson, Matthew J. Frigault, Kathleen Gallagher, Ana P. Castano, Lauren S. Riley, Maria L. Cabral, Angela C. Boroughs, Rubí M.-H. Velasco Cárdenas, Wolfgang Schamel, Jing Zhou, Sean Mackay, Yu-Tzu Tai, Kenneth C. Anderson, Marcela V. Maus
Publikováno v:
Blood Advances, Vol 3, Iss 21, Pp 3248-3260 (2019)
Abstract: Chimeric antigen receptor (CAR) T cells (CARTs) have shown tremendous potential for the treatment of certain B-cell malignancies, including patients with relapsed/refractory multiple myeloma (MM). Targeting the B-cell maturation antigen (BC
Externí odkaz:
https://doaj.org/article/744190eefb7f4eac95dde4520a55224b
Autor:
Bryan D. Choi, Xiaoling Yu, Ana P. Castano, Henia Darr, Daniel B. Henderson, Amanda A. Bouffard, Rebecca C. Larson, Irene Scarfò, Stefanie R. Bailey, Genevieve M. Gerhard, Matthew J. Frigault, Mark B. Leick, Andrea Schmidts, Jason G. Sagert, William T. Curry, Bob S. Carter, Marcela V. Maus
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-8 (2019)
Abstract Despite remarkable success in the treatment of hematological malignancies, CAR T-cell therapies for solid tumors have floundered, in large part due to local immune suppression and the effects of prolonged stimulation leading to T-cell dysfun
Externí odkaz:
https://doaj.org/article/987e2dc848b84c4ebabd4c5eacf43cbb
Autor:
Andrea Schmidts, Leah C Marsh, Ambike A Srivastava, Amanda A Bouffard, Angela C Boroughs, Rebecca C Larson, Felipe Bedoya, Bryan D Choi, Stefanie R Bailey, Mark B Leick, Sonika Vatsa, Michael C Kann, Michelle S Prew, Benjamin P Kleinstiver, J Keith Joung
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Adoptive cell therapy with chimeric antigen receptor T cells (CAR-T) has become a standard treatment for patients with certain aggressive B cell malignancies and holds promise to improve the care of patients suffering from numerous other c
Externí odkaz:
https://doaj.org/article/1383b25b9a8e4f49a0640c17e9556951
Autor:
Marcela V. Maus, Matthew J. Frigault, Kathleen M.E. Gallagher, Ashley Demato, Kevin A. Lindell, Harrison Silva, Andrea Schmidts, Marc Wehrli, Mark B. Leick, Trisha R. Berger, Michael C. Kann, Irene Scarfò, Amanda A. Bouffard, Rebecca C. Larson, Sonika Vatsa, Stefanie R. Bailey
Chimeric antigen receptor (CAR) T cells induce impressive responses in patients with hematologic malignancies but can also trigger cytokine release syndrome (CRS), a systemic toxicity caused by activated CAR T cells and innate immune cells. Although
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304a6031fbfb084825435cf50718e629
https://doi.org/10.1158/2643-3230.c.6550641.v1
https://doi.org/10.1158/2643-3230.c.6550641.v1
Autor:
Marcela V. Maus, Matthew J. Frigault, Kathleen M.E. Gallagher, Ashley Demato, Kevin A. Lindell, Harrison Silva, Andrea Schmidts, Marc Wehrli, Mark B. Leick, Trisha R. Berger, Michael C. Kann, Irene Scarfò, Amanda A. Bouffard, Rebecca C. Larson, Sonika Vatsa, Stefanie R. Bailey
Supplementary Figure from Blockade or Deletion of IFNγ Reduces Macrophage Activation without Compromising CAR T-cell Function in Hematologic Malignancies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa3c245ac8ad9968ea117670a5ca1743
https://doi.org/10.1158/2643-3230.22544430
https://doi.org/10.1158/2643-3230.22544430
Autor:
Marcela V. Maus, Matthew J. Frigault, Kathleen M.E. Gallagher, Ashley Demato, Kevin A. Lindell, Harrison Silva, Andrea Schmidts, Marc Wehrli, Mark B. Leick, Trisha R. Berger, Michael C. Kann, Irene Scarfò, Amanda A. Bouffard, Rebecca C. Larson, Sonika Vatsa, Stefanie R. Bailey
Supplementary Data from Blockade or Deletion of IFNγ Reduces Macrophage Activation without Compromising CAR T-cell Function in Hematologic Malignancies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::892263e8db1e6f8b8ce430812e98389b
https://doi.org/10.1158/2643-3230.22544433
https://doi.org/10.1158/2643-3230.22544433
Autor:
Marcela V. Maus, Matthew J. Frigault, Torben Barington, David M. Weinstock, Henrik J. Ditzel, Morten F. Gjerstorff, Jacob H. Christensen, Charlotte G. Nyvold, Oriane Cédile, Rikke S. Andersen, Bryan D. Choi, Andrea Schmidts, Lauren S. Riley, Rebecca C. Larson, Ana P. Castano, Amanda A. Bouffard, Selena J. Lorrey, Stefanie R. Bailey, Maria L. Cabral, Irene Scarfò, Maria Ormhøj
Supplementary Materials and Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4582e5857ca892ad3132a1732e1514a3
https://doi.org/10.1158/1078-0432.22471292.v1
https://doi.org/10.1158/1078-0432.22471292.v1
Autor:
Marcela V. Maus, Matthew J. Frigault, Torben Barington, David M. Weinstock, Henrik J. Ditzel, Morten F. Gjerstorff, Jacob H. Christensen, Charlotte G. Nyvold, Oriane Cédile, Rikke S. Andersen, Bryan D. Choi, Andrea Schmidts, Lauren S. Riley, Rebecca C. Larson, Ana P. Castano, Amanda A. Bouffard, Selena J. Lorrey, Stefanie R. Bailey, Maria L. Cabral, Irene Scarfò, Maria Ormhøj
Purpose:T cells engineered to express a chimeric antigen receptor (CAR) against CD19 have recently been FDA approved for the treatment of relapsed or refractory large B-cell lymphoma. Despite the success and curative potential of CD19 CAR T cells, se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1dd747a9509cb3fb9a52f5ceb15ca80
https://doi.org/10.1158/1078-0432.c.6527840.v1
https://doi.org/10.1158/1078-0432.c.6527840.v1
Autor:
Andrea Schmidts, Ambike A Srivastava, Rishab Ramapriyan, Stefanie R Bailey, Amanda A Bouffard, Daniel P Cahill, Bob S Carter, William T Curry, Gavin P Dunn, Matthew J Frigault, Elizabeth R Gerstner, Jack Y Ghannam, Michael C Kann, Rebecca C Larson, Mark B Leick, Brian V Nahed, Leland G Richardson, Irene Scarfò, Jing Sun, Hiroaki Wakimoto, Marcela V Maus, Bryan D Choi
Publikováno v:
Neuro-Oncology Advances. 5
Background Chimeric antigen receptor (CAR) T cells have achieved remarkable responses in patients with hematological malignancies; however, the potential of this therapeutic platform for solid tumors like glioblastoma (GBM) has been limited, due in l