Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Amanda A, Hewes"'
Autor:
Cory A. Diemler, Michael MacLean, Sarah E. Heuer, Amanda A. Hewes, Olivia J. Marola, Richard T. Libby, Gareth R. Howell
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
In recent years, microglia have been highlighted for playing integral roles in neurodegenerative diseases, like glaucoma. To better understand the role of microglia during chronic ocular hypertension, we depleted microglia from aged (9–12 months ol
Externí odkaz:
https://doaj.org/article/6b27b539c39343098b06fa8d8c1711f0
Autor:
Brett M. Sansbury, Amanda M. Hewes, Olivia M. Tharp, Sophia B. Masciarelli, Salma Kaouser, Eric B. Kmiec
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Gene correction is often referred to as the gold standard for precise gene editing and while CRISPR-Cas systems continue to expand the toolbox for clinically relevant genetic repair, mechanistic hurdles still hinder widespread implementation
Externí odkaz:
https://doaj.org/article/d54d09c6bc6945aba0290b39b13769d7
Autor:
Kate E. Foley, Amanda A. Hewes, Dylan T. Garceau, Kevin P. Kotredes, Gregory W. Carter, Michael Sasner, Gareth R. Howell
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
IntroductionRestrictions on existing APOE mouse models have impacted research toward understanding the strongest genetic risk factor contributing to Alzheimer’s disease (AD) and dementia, APOEε4, by hindering observation of a key, common genotype
Externí odkaz:
https://doaj.org/article/16f49bfb7bd8496bb1e3d17d7297f768
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 20, Iss , Pp 568-579 (2020)
CRISPR and associated Cas nucleases are genetic engineering tools revolutionizing innovative approaches to cancer and inherited diseases. CRISPR-directed gene editing relies heavily on proper DNA sequence alignment between the guide RNA (gRNA)/CRISPR
Externí odkaz:
https://doaj.org/article/24aac521f8c14efcafcea27ca77d3465
Autor:
Kate E. Foley, Cory A. Diemler, Amanda A. Hewes, Dylan T. Garceau, Michael Sasner, Gareth R. Howell
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction Apolipoprotein E (APOE) ε4 is the strongest genetic risk factor for Alzheimer's disease and related dementias (ADRDs), affecting many different pathways that lead to cognitive decline. Exercise is one of the most widely propose
Externí odkaz:
https://doaj.org/article/dcd697927eed453f8598e777194b09ac
Autor:
Sarah E. Heuer, Kelly J. Keezer, Amanda A. Hewes, Kristen D. Onos, Kourtney C. Graham, Gareth R. Howell, Erik B. Bloss
Publikováno v:
bioRxiv
Common features of Alzheimer’s disease (AD) include amyloid pathology, microglia activation and synaptic dysfunction, however, the causal relationships amongst them remains unclear. Further, human data suggest susceptibility and resilience to AD ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::843fe7be6ac30aaf3fdb7175be91d093
https://doi.org/10.1101/2023.04.28.538728
https://doi.org/10.1101/2023.04.28.538728
Autor:
Amanda E. Hewes, David Cuban, Derrick J. E. Groom, Alyssa J. Sargent, Diego F. Beltrán, Alejandro Rico‐Guevara
Publikováno v:
Journal of morphologyREFERENCES. 283(12)
Nectar-feeding birds provide an excellent system in which to examine form-function relationships over evolutionary time. There are many independent origins of nectarivory in birds, and nectar feeding is a lifestyle with many inherent biophysical cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3439c4f74e2d44e07c1f20fde835be53
https://pubmed.ncbi.nlm.nih.gov/36062802
https://pubmed.ncbi.nlm.nih.gov/36062802
Autor:
null Amanda E. Hewes, null David Cuban, null Derrick J.E. Groom, null Alyssa J. Sargent, null Diego F. Beltrán, null Alejandro Rico‐Guevara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::712d3de8f0c9e381384f40fe1b82e00d
https://doi.org/10.1002/jmor.21513/v2/response1
https://doi.org/10.1002/jmor.21513/v2/response1
Autor:
Kate E. Foley, Cory A. Diemler, Amanda A. Hewes, Dylan T. Garceau, Michael Sasner, Gareth R. Howell
INTRODUCTIONAPOEε4 is the strongest genetic risk factor for Alzheimer’s disease and related dementias (ADRDs) affecting many different pathways that lead to cognitive decline. Exercise is one of the most widely proposed prevention, and interventio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e7d7ee918a8386cfc69fbaedd742aa7
https://doi.org/10.1101/2022.03.01.480612
https://doi.org/10.1101/2022.03.01.480612
Publikováno v:
Journal of Experimental Biology. 225
Nectar-feeding birds employ unique mechanisms to collect minute liquid rewards hidden within floral structures. In recent years, techniques developed to study drinking mechanisms in hummingbirds have prepared the groundwork for investigating nectar f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e77086fbfa887dc0795e0f07a49a921d
https://doi.org/10.1242/jeb.243096
https://doi.org/10.1242/jeb.243096