Zobrazeno 1 - 10 of 38 pro vyhledávání: '"Amand Chesnel"'
1
Akademický článek
Low-Dose Alkylphenol Exposure Promotes Mammary Epithelium Alterations and Transgenerational Developmental Defects, But Does Not Enhance Tumorigenic Behavior of Breast Cancer Cells
Autor: Clémence Chamard-Jovenin, Charlène Thiebaut, Amand Chesnel, Emmanuel Bresso, Chloé Morel, Malika Smail-Tabbone, Marie-Dominique Devignes, Taha Boukhobza, Hélène Dumond
Publikováno v: Frontiers in Endocrinology, Vol 8 (2017)
Fetal and neonatal exposure to long-chain alkylphenols has been suspected to promote breast developmental disorders and consequently to increase breast cancer risk. However, disease predisposition from developmental exposures remains unclear. In this
Externí odkaz: https://doaj.org/article/aa6ed05746ef4d8bb74e87c459657491
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2
Akademický článek
Mammary epithelial cell phenotype disruption in vitro and in vivo through ERalpha36 overexpression.
Autor: Charlène Thiebaut, Clémence Chamard-Jovenin, Amand Chesnel, Chloé Morel, El-Hadi Djermoune, Taha Boukhobza, Hélène Dumond
Publikováno v: PLoS ONE, Vol 12, Iss 3, p e0173931 (2017)
Estrogen receptor alpha 36 (ERα36) is a variant of the canonical estrogen receptor alpha (ERα66), widely expressed in hormone sensitive cancer cells and whose high expression level correlates with a poor survival prognosis for breast cancer patient
Externí odkaz: https://doaj.org/article/65f23304133b4a6395e064879c482459
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3
Akademický článek
An alkylphenol mix promotes seminoma derived cell proliferation through an ERalpha36-mediated mechanism.
Autor: Hussein Ajj, Amand Chesnel, Sophie Pinel, François Plenat, Stephane Flament, Helene Dumond
Publikováno v: PLoS ONE, Vol 8, Iss 4, p e61758 (2013)
Long chain alkylphenols are man-made compounds still present in industrial and agricultural processes. Their main use is domestic and they are widespread in household products, cleansers and cosmetics, leading to a global environmental and human cont
Externí odkaz: https://doaj.org/article/2bd0627e68c242ac8e90819e061bed41
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4
The role of ERα36 in development and tumor malignancy
Autor: Marie-Justine Guerquin, Gabriel Livera, Amand Chesnel, Henri-Philippe Konan, Charlène Thiébaut, Muriel Le Romancer, Hélène Dumond
Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2020, 21 (11), pp.4116. ⟨10.3390/ijms21114116⟩
International Journal of Molecular Sciences, Vol 21, Iss 4116, p 4116 (2020)
International Journal of Molecular Sciences, MDPI, 2020, 21 (11), pp.4116. ⟨10.3390/ijms21114116⟩
International audience; Estrogen nuclear receptors, represented by the canonical forms ERα66 and ERβ1, are the main mediators of the estrogen-dependent pathophysiology in mammals. However, numerous isoforms have been identified, stimulating unconve
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a5e54f824710d712bffcecbfadb2457
https://hal.science/hal-02890613
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5
Dual Epigenetic Regulation of ERα36 Expression in Breast Cancer Cells
Autor: Jean-Louis Merlin, Maelle Chesnel, Charlène Thiébaut, Hélène Dumond, Alexandre Harlé, Agnès Leroux, Amand Chesnel
Publikováno v: International Journal of Molecular Sciences, Vol 20, Iss 11, p 2637 (2019)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2019, 20 (11), pp.2637. ⟨10.3390/ijms20112637⟩
Volume 20
Issue 11
Breast cancer remains the major cause of cancer-induced morbidity and mortality in women. Among the different molecular subtypes, luminal tumors yet considered of good prognosis often develop acquired resistance to endocrine therapy. Recently, misreg
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c8025c25cc127b041c83cfb3b60836c
https://www.mdpi.com/1422-0067/20/11/2637
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6
Müllerian Inhibiting Substance in the Caudate Amphibian Pleurodeles waltl
Autor: Stéphane Flament, Nathalie di Clemente, Amand Chesnel, Hélène Dumond, Dominique Chardard, Jean-Yves Picard, Imane Al-Asaad
Publikováno v: Endocrinology
Endocrinology, Endocrine Society, 2013, 154 (10), pp.3931-3936. ⟨10.1210/en.2013-1229⟩
International audience; Müllerian inhibiting substance (MIS, also known as anti-Müllerian hormone), is a key factor of male sex differentiation in vertebrates. In amniotes, it is responsible for Müllerian duct regression in male embryos. In fish,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019c32c6f81f2c0f563c9c577cb30878
https://doi.org/10.1210/en.2013-1229
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7
Busulfan-Mediated Germ Cell Depletion Does Not Alter Gonad Differentiation in the Urodele Amphibian Pleurodeles waltl
Autor: Stéphane Flament, Hélène Dumond, Dominique Chardard, Amand Chesnel, I Al-Asaad
Publikováno v: Sexual Development. 6:188-200
It is not known in urodele amphibians whether germ cells (GCs) are indispensable for gonadal differentiation. In order to address this question in the newt Pleurodeles waltl, we first cloned the ortholog of VASA which is known as a GC marker in many
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64b437a888fec49d41d83330c1503891
https://doi.org/10.1159/000337957
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8
Female-enriched expression of ERα during gonad differentiation of the urodele amphibian Pleurodeles waltl
Autor: Stéphane Flament, Chia-I Ko, Amand Chesnel, Sabine Mazerbourg, Dominique Chardard, Sandra Kuntz
Publikováno v: General and Comparative Endocrinology. 156:234-245
In the amphibian Pleurodeles waltl, estradiol treatment of genetically male larvae (ZZ) induces male-to-female sex reversal whereas heat treatment of genetically female larvae (ZW) inhibits estradiol synthesis and leads to female-to-male sex reversal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d02752b2641d19b868a4eb9479f545
https://doi.org/10.1016/j.ygcen.2008.01.012
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9
Sexual Development of the Urodele Amphibian Pleurodeles waltl
Autor: Hélène Dumond, A. Wallacides, Stéphane Flament, Amand Chesnel, Sandra Kuntz, Dominique Chardard, C.-I. Ko
Publikováno v: Sexual Development. 2:104-114
Pleurodeles waltl is a urodele amphibian that displays a ZZ/ZW genetic mode of sex determination involving a putative W-borne dominant determinant. This determining pathway can be environmentally inhibited since heat treated ZW larvae undergo a funct
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35a6006ebc16f0953db65f6b27fbd921
https://doi.org/10.1159/000129695
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10
Female-enriched and thermosensitive expression of steroidogenic factor-1 during gonadal differentiation in Pleurodeles waltl
Autor: Hélène Dumond, Sandra Kuntz, Dominique Chardard, Amand Chesnel, C.-I. Ko, Ducatez M, M. Callier, S. Flament
Publikováno v: Journal of Molecular Endocrinology
Journal of Molecular Endocrinology, BioScientifica, 2006, 36 (1), pp.175-186. ⟨10.1677/jme.1.01916⟩
In the urodele amphibian Pleurodeles waltl, sex differentiation is genetically controlled, that is, ZZ male vs ZW female, but may be influenced by temperature, which induces a female-to-male sex reversal. We investigated whether steroidogenic factor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5ff92bd70332be73f7cd7505ceb86f8
https://doi.org/10.1677/jme.1.01916
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