Zobrazeno 1 - 10
of 360
pro vyhledávání: '"Amancio Carnero"'
Autor:
Elisa Suárez-Martínez, Sander R. Piersma, Thang V. Pham, Irene V. Bijnsdorp, Connie R. Jimenez, Amancio Carnero
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-18 (2024)
Abstract Background Ovarian cancer has a high mortality rate mainly due to its resistance to currently used therapies. This resistance has been associated with the presence of cancer stem cells (CSCs), interactions with the microenvironment, and intr
Externí odkaz:
https://doaj.org/article/af08a23f399f4704a81219517ab21154
Autor:
Sandra Muñoz-Galván, Eva M. Verdugo-Sivianes, José M. Santos-Pereira, Purificación Estevez-García, Amancio Carnero
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-20 (2024)
Abstract Background Hypoxia in solid tumors is an important source of chemoresistance that can determine poor patient prognosis. Such chemoresistance relies on the presence of cancer stem cells (CSCs), and hypoxia promotes their generation through tr
Externí odkaz:
https://doaj.org/article/89219abe5c9c4b8a992a54ba97e0b98a
Autor:
Javier Martin-Broto, Jeronimo Martinez-Garcia, David S. Moura, Andres Redondo, Antonio Gutierrez, Antonio Lopez-Pousa, Javier Martinez-Trufero, Isabel Sevilla, Roberto Diaz-Beveridge, Maria Pilar Solis-Hernandez, Amancio Carnero, Marco Perez, David Marcilla, Jesus Garcia-Foncillas, Pablo Romero, Javier Fernandez-Jara, Daniel Lopez-Lopez, Ivan Arribas, Nadia Hindi
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-10 (2023)
Abstract Cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors demonstrated activity in terms of progression-free survival (PFS) in advanced dedifferentiated liposarcoma (DD-LPS), a sarcoma with CDK4 amplification. CDK4 overexpression is by far more c
Externí odkaz:
https://doaj.org/article/0c66d90901d244e6922dd1f9ea0a3f1f
Autor:
Laura Pérez-Martínez, Lourdes Romero, Eva M Verdugo-Sivianes, Sandra Muñoz-Galván, Susana Rubio-Mediavilla, Ana Amiama-Roig, Amancio Carnero, José-Ramón Blanco
Publikováno v:
PLoS ONE, Vol 19, Iss 1, p e0286201 (2024)
Cellular senescence and low-grade inflammation favor the acceleration of aging. The liver is an essential metabolic organ because changes related to its function are related to age-related diseases. The objective of this study was to evaluate the eff
Externí odkaz:
https://doaj.org/article/0e2099a9454f401a93344409bc5a8306
Autor:
José Manuel García-Heredia, Marco Pérez, Eva M. Verdugo-Sivianes, María M. Martínez-Ballesteros, Sara M. Ortega-Campos, Amancio Carnero
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-4 (2023)
Externí odkaz:
https://doaj.org/article/98e8d4e088fe4c25882b7ce4f639555f
Autor:
Lola E. Navas, Elena Blanco-Alcaina, Elisa Suarez-Martinez, Eva M. Verdugo-Sivianes, Asuncion Espinosa-Sanchez, Laura Sanchez-Diaz, Eduardo Dominguez-Medina, Ceres Fernandez-Rozadilla, Angel Carracedo, Lindsay E. Wu, Amancio Carnero
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-16 (2023)
Summary Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous group of tumors that affect different anatomical locations. Despite this heterogeneity, HNSCC treatment depends on the anatomical location, TNM stage and resectability of the tu
Externí odkaz:
https://doaj.org/article/6d870a496a874977b5ee1ff2b864729b
Publikováno v:
Genes and Diseases, Vol 10, Iss 1, Pp 187-198 (2023)
SPINOPHILIN (SPN, PPP1R9B or NEURABIN-2) is a multifunctional protein that regulates protein–protein interactions in different cell signaling pathways. SPN is also one of the regulatory subunits of protein phosphatase 1 (PP1), implicated in the dep
Externí odkaz:
https://doaj.org/article/b1bc5e3fe7ab4f5ea702d2db8d769381
Autor:
Ángela Marrugal, Irene Ferrer, Álvaro Quintanal-Villalonga, Laura Ojeda, María Dolores Pastor, Ricardo García-Luján, Amancio Carnero, Luis Paz-Ares, Sonia Molina-Pinelo
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 13830 (2023)
The use of 90 kDa heat shock protein (HSP90) inhibition as a therapy in lung adenocarcinoma remains limited due to moderate drug efficacy, the emergence of drug resistance, and early tumor recurrence. The main objective of this research is to maximiz
Externí odkaz:
https://doaj.org/article/1b4d544993934a80be7929a73d66769e
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract In nature, cells reside in tissues subject to complex cell–cell interactions, signals from extracellular molecules and niche soluble and mechanical signaling. These microenvironment interactions are responsible for cellular phenotypes and
Externí odkaz:
https://doaj.org/article/f412dfa903d34b1691eeb1c3efc4c2a9
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-18 (2021)
Abstract Background Sarcomas are a very heterogeneous group of tumors with intrinsic developmental programs derived from the cell of origin. This implies a functional hierarchy inside tumors governed by sarcoma stem cells. Therefore, genetic and/or e
Externí odkaz:
https://doaj.org/article/dbe4cc9362e948bca2a8e6494a60bf84