Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Aman Iqbal"'
Autor:
Yanli Liu, Aman Iqbal, Weiguo Li, Zuyao Ni, Yalong Wang, Jurupula Ramprasad, Karan Joshua Abraham, Mengmeng Zhang, Dorothy Yanling Zhao, Su Qin, Peter Loppnau, Honglv Jiang, Xinghua Guo, Peter J. Brown, Xuechu Zhen, Guoqiang Xu, Karim Mekhail, Xingyue Ji, Mark T. Bedford, Jack F. Greenblatt, Jinrong Min
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The SMN protein recognizes symmetric dimethylarginine by its Tudor domain, and SMN deficiency leads to spinal muscular atrophy. Here, Liu et al. discover a small molecule that binds to the SMN Tudor domain and disrupts the interaction between SMN and
Externí odkaz:
https://doaj.org/article/a0e6fffeffbb41e8b6c0ef99920dda4b
Autor:
Steinhardt, Laura C, Aman, Iqbal, Pakzad, Iqbalshah, Kumar, Binay, Singh, Lakhwinder P, Peters, David
Publikováno v:
Health Policy and Planning, 2011 Nov 01. 26, ii92-ii103.
Externí odkaz:
https://www.jstor.org/stable/45090784
Autor:
Christopher N. Johnson, Nicola E. Wilsher, Vanessa Martins, Gianni Chessari, Aman Iqbal, Torren M. Peakman, Pamela A. Williams, Keisha Hearn, George Ward, Edward J. Lewis, James Edward Harvey Day, Ildiko Maria Buck, Charlotte Mary Griffiths-Jones, Tom D. Heightman, Michael Reader, Sharna J. Rich, Martyn Frederickson, Elisabetta Chiarparin, Emiliano Tamanini
Publikováno v:
Journal of Medicinal Chemistry. 60:4611-4625
XIAP and cIAP1 are members of the inhibitor of apoptosis protein (IAP) family and are key regulators of anti-apoptotic and pro-survival signaling pathways. Overexpression of IAPs occurs in various cancers and has been associated with tumor progressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7d09110b6e7f734dc47b47bfcebcacb
https://doi.org/10.1021/acs.jmedchem.6b01877
https://doi.org/10.1021/acs.jmedchem.6b01877
Autor:
Steven Kennedy, Sean K. Liew, Matthieu Schapira, Masoud Vedadi, Abdellah Allali-Hassani, Cheryl H. Arrowsmith, Scott Houliston, Andrei K. Yudin, Jinrong Min, Diego B. Diaz, P. Mader, Hong Wu, Aman Iqbal, Aiping Dong, Vijayaratnam Santhakumar, Rodrigo Mendoza-Sanchez, Renato Ferreira de Freitas, Victoria B. Corless, David Smil, Peter Brown, Ludmila Dombrovski, Elena Dobrovetsky, Carlo C. dela Seña
Publikováno v:
Bioorganicmedicinal chemistry. 27(17)
SET domain bifurcated protein 1 (SETDB1) is a human histone-lysine methyltransferase, which is amplified in human cancers and was shown to be crucial in the growth of non-small and small cell lung carcinoma. In addition to its catalytic domain, SETDB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::279b1b546c4df6dc0f23953355372074
https://pubmed.ncbi.nlm.nih.gov/31327677
https://pubmed.ncbi.nlm.nih.gov/31327677
Autor:
Lydia Y. W. Lee, Aman Iqbal, Sahil Patel, Gordon Saxty, Carr Maria Grazia, Valerio Berdini, Keisha Hearn, Ildiko Maria Buck, Christopher William Murray, Kirsten V. Smith, Anne Cleasby, Paul N. Mortenson, Vanessa Martins, Joseph E. Coyle, Jayne Curry, Joanne M. Munck, Phillip J. Day, Susan Roomans, James Edward Harvey Day, Emiliano Tamanini, Lee William Page
Publikováno v:
ACS Medicinal Chemistry Letters. 6:798-803
The DDR1 and DDR2 receptor tyrosine kinases are activated by extracellular collagen and have been implicated in a number of human diseases including cancer. We performed a fragment-based screen against DDR1 and identified fragments that bound either
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67cc4aabaaba0c23f9593552e8263dd9
https://doi.org/10.1021/acsmedchemlett.5b00143
https://doi.org/10.1021/acsmedchemlett.5b00143
Autor:
Danton Ivanochko, Peter Brown, Lixin Fan, Shili Duan, Guillermo Senisterra, Cheryl H. Arrowsmith, Alexander Lemak, Aman Iqbal, Lilia Kaustov, R. Scott Houliston, Yun-Xing Wang, Michelle S. Ong
Publikováno v:
The Journal of Biological Chemistry
UHRF1 is a key mediator of inheritance of epigenetic DNA methylation patterns during cell division and is a putative target for cancer therapy. Recent studies indicate that interdomain interactions critically influence UHRF1's chromatin-binding prope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75ed82e9af224026dfe3bad356e26df
https://pubmed.ncbi.nlm.nih.gov/29074623
https://pubmed.ncbi.nlm.nih.gov/29074623
Autor:
Emily Flashman, Christopher J. Schofield, Rasheduzzaman Chowdhury, Jacob T. Bush, Andrea Szöllössi, Timothy D. W. Claridge, Aman Iqbal, Luc Henry, Ivanhoe K. H. Leung, Hanna Tarhonskaya
Deacetoxycephalosporin C synthase (DAOCS) catalyzes the oxidative ring expansion of penicillin N (penN) to give deacetoxycephalosporin C (DAOC), which is the committed step in the biosynthesis of the clinically important cephalosporin antibiotics. DA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00502cb7357256d4be6c03a7fdea719c
https://doi.org/10.1021/bi500086p
https://doi.org/10.1021/bi500086p
Autor:
Peter Brown, Aman Iqbal
Publikováno v:
Fragment-based Drug Discovery Lessons and Outlook
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73b70243fa7a61a29f69027e968fbfed
https://doi.org/10.1002/9783527683604.ch15
https://doi.org/10.1002/9783527683604.ch15
Autor:
Aman Iqbal, Matthew E.C. Caines, Nadia J. Kershaw, Inger Andersson, Alasdair Mackenzie, Christopher J. Schofield, Karin Valegård, Susan E. Jensen
Publikováno v:
Journal of Molecular Biology. 396:332-344
Clavulanic acid (CA) is a clinically important beta-lactamase inhibitor that is produced by fermentation of Streptomyces clavuligerus. The CA biosynthesis pathway starts from arginine and glyceraldehyde-3-phosphate and proceeds via (3S,5S)-clavaminic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d0418bb90a847ae5057bf0be80413e8
https://doi.org/10.1016/j.jmb.2009.11.045
https://doi.org/10.1016/j.jmb.2009.11.045
Autor:
Tom Brown, Rasheduzzaman Chowdhury, Christopher J. Schofield, Haren Arunlanantham, Nadia J. Kershaw, Michael A. McDonough, Kirsty S. Hewitson, Ian J. Clifton, Aman Iqbal
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 78:1398-1407
(3R,5R)-Clavulanic acid (CA) is a clinically important inhibitor of Class A β-lactamases. Sequence comparisons suggest that orf14 of the clavulanic acid biosynthesis gene cluster encodes for an acetyl transferase (CBG). Crystallographic studies reve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd8ac05a04308118cac718416ce80b38
https://doi.org/10.1002/prot.22653
https://doi.org/10.1002/prot.22653