Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Amalia Penna"'
Autor:
Camilla Tiezzi, Marzia Rossi, Andrea Vecchi, Sara Doselli, Amalia Penna, Paola Fisicaro, Ilaria Montali, Camilla Ceccatelli Berti, Valentina Reverberi, Anna Montali, Gabriele Missale, Carlo Ferrari, Carolina Boni
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102584- (2023)
Summary: Monitoring antigen-specific T cell frequency and function is essential to assess the host immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Here, we present a FluoroSpot assay for concurrently detecti
Externí odkaz:
https://doaj.org/article/1f4b8be0526e456ab475800c1653cc70
Autor:
Camilla Tiezzi, Andrea Vecchi, Marzia Rossi, Davide Cavazzini, Angelo Bolchi, Diletta Laccabue, Sara Doselli, Amalia Penna, Luca Sacchelli, Federica Brillo, Tiziana Meschi, Andrea Ticinesi, Antonio Nouvenne, Gaetano Donofrio, Paola Zanelli, Magda Benecchi, Silvia Giuliodori, Paola Fisicaro, Ilaria Montali, Camilla Ceccatelli Berti, Valentina Reverberi, Anna Montali, Simona Urbani, Giuseppe Pedrazzi, Gabriele Missale, Amalio Telenti, Davide Corti, Simone Ottonello, Carlo Ferrari, Carolina Boni
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106940- (2023)
Summary: Humoral immunity is sensitive to evasion by SARS-CoV-2 mutants, but CD8 T cells seem to be more resistant to mutational inactivation. By a systematic analysis of 30 spike variant peptides containing the most relevant VOC and VOI mutations th
Externí odkaz:
https://doaj.org/article/97b7605f9fec49e3851ab733c6788d02
Autor:
Valeria Barili, Paola Fisicaro, Barbara Montanini, Greta Acerbi, Anita Filippi, Giovanna Forleo, Chiara Romualdi, Manuela Ferracin, Francesca Guerrieri, Giuseppe Pedrazzi, Carolina Boni, Marzia Rossi, Andrea Vecchi, Amalia Penna, Alessandra Zecca, Cristina Mori, Alessandra Orlandini, Elisa Negri, Marco Pesci, Marco Massari, Gabriele Missale, Massimo Levrero, Simone Ottonello, Carlo Ferrari
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Here, the authors report that exhausted HCV-specific CD8+ T cells are marked by upregulation of p53 signaling already detectable in an early phase of chronic HCV infection and by a later development of a repressive chromatin state, and show that chem
Externí odkaz:
https://doaj.org/article/f288f9a480d84b95aefe427ed5f160f3
Autor:
Ilaria Montali, Andrea Vecchi, Marzia Rossi, Camilla Tiezzi, Amalia Penna, Valentina Reverberi, Diletta Laccabue, Gabriele Missale, Carolina Boni, Paola Fisicaro
Publikováno v:
Biomedicines, Vol 10, Iss 6, p 1224 (2022)
Current treatment for chronic HBV infection is mainly based on nucleos(t)ide analogues, that in most cases need to be administered for a patient’s lifetime. There is therefore a pressing need to develop new therapeutic strategies to shorten antivir
Externí odkaz:
https://doaj.org/article/734d9e8e8a624b708ff54f4ce02dc9df
Autor:
Paola Fisicaro, Valeria Barili, Marzia Rossi, Ilaria Montali, Andrea Vecchi, Greta Acerbi, Diletta Laccabue, Alessandra Zecca, Amalia Penna, Gabriele Missale, Carlo Ferrari, Carolina Boni
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
A great effort of research has been devoted in the last few years to developing new anti-HBV therapies of finite duration that also provide effective sustained control of virus replication and antigen production. Among the potential therapeutic strat
Externí odkaz:
https://doaj.org/article/e3c4210d58354b6fb33a1528e5d51967
Autor:
Valeria Barili, Andrea Vecchi, Marzia Rossi, Ilaria Montali, Camilla Tiezzi, Amalia Penna, Diletta Laccabue, Gabriele Missale, Paola Fisicaro, Carolina Boni
Publikováno v:
Cells, Vol 10, Iss 10, p 2563 (2021)
In chronic hepatitis B and C virus infections persistently elevated antigen levels drive CD8+ T cells toward a peculiar differentiation state known as T cell exhaustion, which poses crucial constraints to antiviral immunity. Available evidence indica
Externí odkaz:
https://doaj.org/article/3dd6d0c9750048c386f4772f83e89ffa
Autor:
Paola Fisicaro, Marzia Rossi, Andrea Vecchi, Greta Acerbi, Valeria Barili, Diletta Laccabue, Ilaria Montali, Alessandra Zecca, Amalia Penna, Gabriele Missale, Carlo Ferrari, Carolina Boni
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 20, p 5080 (2019)
Immune modulatory therapies are widely believed to represent potential therapeutic strategies for chronic hepatitis B infection (CHB). Among the cellular targets for immune interventions, Natural Killer (NK) cells represent possible candidates becaus
Externí odkaz:
https://doaj.org/article/ace37772dcd749e184087e58d2a735bc
Autor:
Carolina Boni, Valeria Barili, Greta Acerbi, Marzia Rossi, Andrea Vecchi, Diletta Laccabue, Amalia Penna, Gabriele Missale, Carlo Ferrari, Paola Fisicaro
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 11, p 2754 (2019)
Chronic hepatitis B virus (HBV) infection represents a worldwide public health concern with approximately 250 million people chronically infected and at risk of developing liver cirrhosis and hepatocellular carcinoma. Nucleos(t)ide analogues (NUC) ar
Externí odkaz:
https://doaj.org/article/7cbbdc076b5846afb903f5d2ca0bfe20
Autor:
Ilaria Montali, Camilla Ceccatelli Berti, Marco Morselli, Greta Acerbi, Valeria Barili, Giuseppe Pedrazzi, Barbara Montanini, Carolina Boni, Arianna Alfieri, Marco Pesci, Alessandro Loglio, Elisabetta Degasperi, Marta Borghi, Riccardo Perbellini, Amalia Penna, Diletta Laccabue, Marzia Rossi, Andrea Vecchi, Camilla Tiezzi, Valentina Reverberi, Chiara Boarini, Gianluca Abbati, Marco Massari, Pietro Lampertico, Gabriele Missale, Carlo Ferrari, Paola Fisicaro
Publikováno v:
Journal of Hepatology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efb81d13d15d11d0e330c6d768bf96d6
https://doi.org/10.1016/j.jhep.2023.02.035
https://doi.org/10.1016/j.jhep.2023.02.035
Autor:
Marzia Rossi, Andrea Vecchi, Camilla Tiezzi, Valeria Barili, Paola Fisicaro, Amalia Penna, Ilaria Montali, Stephane Daffis, Simon P Fletcher, Anuj Gaggar, Jonathan Medley, Michael Graupe, Latesh Lad, Alessandro Loglio, Roberta Soffredini, Marta Borghi, Teresa Pollicino, Cristina Musolino, Arianna Alfieri, Federica Brillo, Diletta Laccabue, Marco Massari, Chiara Boarini, Gianluca Abbati, Giuseppe Pedrazzi, Gabriele Missale, Pietro Lampertico, Carlo Ferrari, Carolina Boni
Publikováno v:
Gut. :gutjnl-2022
ObjectiveExhausted hepatitis B virus (HBV)-specific CD8 T cells in chronic HBV infection are broadly heterogeneous. Characterisation of their functional impairment may allow to distinguish patients with different capacity to control infection and rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca9cbc2cb47738426d0d3ff0d755465a
https://doi.org/10.1136/gutjnl-2022-327202
https://doi.org/10.1136/gutjnl-2022-327202