Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Amalia M Dolga"'
Autor:
Wondwossen M Yeshaw, Marianne van der Zwaag, Francesco Pinto, Liza L Lahaye, Anita IE Faber, Rubén Gómez-Sánchez, Amalia M Dolga, Conor Poland, Anthony P Monaco, Sven CD van IJzendoorn, Nicola A Grzeschik, Antonio Velayos-Baeza, Ody CM Sibon
Publikováno v:
eLife, Vol 8 (2019)
The VPS13A gene is associated with the neurodegenerative disorder Chorea Acanthocytosis. It is unknown what the consequences are of impaired function of VPS13A at the subcellular level. We demonstrate that VPS13A is a peripheral membrane protein, ass
Externí odkaz:
https://doaj.org/article/82c95e0d7eb64c9cabeaa87ffdcdcbf4
Autor:
Naďa Majerníková, Alejandro Marmolejo-Garza, Casandra Salinas Salinas, Minh D. A. Luu, Yuequ Zhang, Marina Trombetta-Lima, Tamara Tomin, Ruth Birner-Gruenberger, Šárka Lehtonen, Jari Koistinaho, Justina C. Wolters, Scott Ayton, Wilfred F. A. den Dunnen, Amalia M. Dolga
Publikováno v:
Cell Death and Disease, Vol 15, Iss 10, Pp 1-15 (2024)
Abstract Alzheimer’s disease (AD) affects millions of people worldwide and represents the most prevalent form of dementia. Treatment strategies aiming to interfere with the formation of amyloid β (Aβ) plaques and neurofibrillary tangles (NFTs), t
Externí odkaz:
https://doaj.org/article/b3a270feb1264fceb2a93bf047d1b14d
Autor:
Alejandro Marmolejo-Garza, Laurent Chatre, Deborah L. Croteau, Alejandro Herron-Bedoya, Minh Danh Anh Luu, Benoit Bernay, Julien Pontin, Vilhelm A. Bohr, Erik Boddeke, Amalia M. Dolga
Publikováno v:
Neurobiology of Disease, Vol 200, Iss , Pp 106645- (2024)
Summary: Nicotinamide riboside (NR), a precursor of nicotinamide adenine dinucleotide (NAD+), has robust cognitive benefits and alleviates neuroinflammation in Alzheimer's Disease (AD) mouse models without decreasing beta-amyloid plaque pathology. Su
Externí odkaz:
https://doaj.org/article/4ee99df2197a4223b78289600027be29
Autor:
Saravana R K Murthy, Tessi Sherrin, Chad Jansen, Ingrid Nijholt, Michael Robles, Amalia M Dolga, Nicolas Andreotti, Jean-Marc Sabatier, Hans-Guenther Knaus, Reinhold Penner, Cedomir Todorovic, Thomas Blank
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127264 (2015)
Small-conductance, Ca2+ activated K+ channels (SK channels) are expressed at high levels in brain regions responsible for learning and memory. In the current study we characterized the contribution of SK2 channels to synaptic plasticity and to differ
Externí odkaz:
https://doaj.org/article/108d442b622c4f08a8e575521f505c73
Autor:
Deng Chen, Chunlong Zhao, Jianqiu Zhang, Catharina W. J. Knol, Angelina Osipyan, Nad'a Majerníková, Tingting Chen, Zhangping Xiao, Jeaunice Adriana, Andrew J. Griffith, Abel Soto Gamez, Petra E. van derWouden, Robert P. Coppes, Amalia M. Dolga, Hidde J. Haisma, Frank J. Dekker
Publikováno v:
Advanced Science, Vol 11, Iss 32, Pp n/a-n/a (2024)
Abstract Ferroptosis is a form of regulated cell death that can be modulated by small molecules and has the potential for the development of therapeutics for oncology. Although excessive lipid peroxidation is the defining hallmark of ferroptosis, DNA
Externí odkaz:
https://doaj.org/article/5f1b5535d1c64d3381cee0b2777a4e5b
Autor:
Isabella Cattani-Cavalieri, Marina Trombetta-Lima, Hong Yan, Ana L. Manzano-Covarrubias, Hoeke A. Baarsma, Asmaa Oun, Melissa Mol van der Veen, Emily Oosterhout, Amalia M. Dolga, Rennolds S. Ostrom, Samuel Santos Valenca, Martina Schmidt
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
Introduction: Air pollution from diesel combustion is linked in part to the generation of diesel exhaust particles (DEP). DEP exposure induces various processes, including inflammation and oxidative stress, which ultimately contribute to a decline in
Externí odkaz:
https://doaj.org/article/4610bf6e0c5a40caa4eaa192573cc12d
Autor:
Amalia M Dolga, Carsten eCulmsee
Publikováno v:
Frontiers in Pharmacology, Vol 3 (2012)
New concepts on potassium channel function in neuroinflammation suggest that they regulate mechanisms of microglial activation, including intracellular calcium homeostasis, morphological alterations, pro-inflammatory cytokine release, antigen present
Externí odkaz:
https://doaj.org/article/87acc8000c8449cdae89ae4f2e57a233
Autor:
Els F. E. Kuiper, Ad eNelemans, Paul G. M. Luiten, Ingrid M. Nijholt, Amalia M Dolga, Uli L. M. Eisel
Publikováno v:
Frontiers in Pharmacology, Vol 3 (2012)
Calcium-activated potassium (KCa) channels are present throughout the central nervous system as well as many peripheral tissues. Activation of KCa channels is essential for maintenance of the neuronal membrane potential and was shown to underlie the
Externí odkaz:
https://doaj.org/article/130a1cb0b4b046089fa9a79987b6a97a
Autor:
Alejandro Marmolejo-Garza, Inge E. Krabbendam, Minh Danh Anh Luu, Famke Brouwer, Marina Trombetta-Lima, Osman Unal, Shane J. O’Connor, Naďa Majerníková, Carolina R. S. Elzinga, Cristina Mammucari, Martina Schmidt, Muniswamy Madesh, Erik Boddeke, Amalia M. Dolga
Publikováno v:
Cell Death and Disease, Vol 14, Iss 11, Pp 1-15 (2023)
Abstract Ferroptosis is an iron- and reactive oxygen species (ROS)-dependent form of regulated cell death, that has been implicated in Alzheimer’s disease and Parkinson’s disease. Inhibition of cystine/glutamate antiporter could lead to mitochond
Externí odkaz:
https://doaj.org/article/691ff9c44b724f72bdd4f4130f56e6a5
Autor:
Natalia Ortí-Casañ, Ate S. Boerema, Karina Köpke, Amber Ebskamp, Jan Keijser, Yuequ Zhang, Tingting Chen, Amalia M. Dolga, Kerensa Broersen, Roman Fischer, Klaus Pfizenmaier, Roland E. Kontermann, Ulrich L. M. Eisel
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Tumor necrosis factor alpha (TNF-α) and its key role in modulating immune responses has been widely recognized as a therapeutic target for inflammatory and neurodegenerative diseases. Even though inhibition of TNF-α is beneficial for the t
Externí odkaz:
https://doaj.org/article/c98638b7b125423496722b05327a5864