Výsledky vyhledávání - "Amalia Di Gianuario"

Further studies on arylpiperazinyl alkyl pyridazinones: discovery of an exceptionally potent, orally active, antinociceptive agent in thermally induced pain

Autor: Claudio Biancalani, Maria Paola Giovannoni, Nicoletta Cesari, Stefano Pieretti, Alessia Graziano, Agostino Cilibrizzi, Vittorio Dal Piaz, Giorgina Mangano, Lorenzo Polenzani, Amalia Di Gianuario, Mariantonella Colucci, Claudia Vergelli, Beatrice Garrone

Publikováno v: Journal of medicinal chemistry. 52(23)

A number of pyridazinone derivatives bearing an arylpiperazinylalkyl chain were synthesized and tested icv in a model of acute nociception induced by thermal stimuli in mice (tail flick). The most interesting and potent compound in this series was 6a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c392c0ba44dd0c5c4346ec371bc3201e
https://pubmed.ncbi.nlm.nih.gov/19788200

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