Gut microbiota trajectory in early life may predict development of celiac disease

Autor: Marta Olivares, Alan W. Walker, Amalia Capilla, Alfonso Benítez-Páez, Francesc Palau, Julian Parkhill, Gemma Castillejo, Yolanda Sanz

Publikováno v: Microbiome, Vol 6, Iss 1, Pp 1-11 (2018)

Abstract Background To investigate whether alterations in the developing intestinal microbiota and immune markers precede celiac disease (CD) onset in infants at familial risk of developing the disease. Methods A nested case-control study was carried

Externí odkaz: https://doaj.org/article/9d31b6f03d90498bac47bee0a1c19068

Modeling APC mutagenesis and familial adenomatous polyposis using human iPS cells.

Autor: Cesar A Sommer, Amalia Capilla, Francisco J Molina-Estevez, Andreia Gianotti-Sommer, Nicholas Skvir, Ignacio Caballero, Sanjib Chowdhury, Gustavo Mostoslavsky

Publikováno v: PLoS ONE, Vol 13, Iss 7, p e0200657 (2018)

Mutations in the gene Adenomatous Polyposis Coli or APC appear in most sporadic cases of colorectal cancer and it is the most frequent mutation causing hereditary Familial Adenomatous Polyposis. The detailed molecular mechanism by which APC mutations

Externí odkaz: https://doaj.org/article/ccbce417250044d2970a8ffb96329335

Variants in Interferon Lambda are Associated with Very Early Onset Inflammatory Bowel Disease

Autor: Jodie D. Ouahed, Achille Broggi, Abigail Glick, Robin T. Haring, Michael Field, Daniel Chinnapen, Michael J. Grey, Wayne Lencer, Steven J. Steiner, Evida Dennis-Heyward, Noah Shroyer, Zachary Criss, Shih-Ching Lin, Xi-Lei Zeng, Sue E. Crawford, Mary K. Estes, Jay R. Thiagarajah, Amalia Capilla, Whitney Scoon, Gustavo Mostoslavsky, Jason Spence, Christoph Klein, Aleixo M. Muise, Bruce Horwitz, Ivan Zanoni, Scott B. Snapper

Inflammatory bowel diseases (IBD) are chronic inflammatory disorders of the intestine that affect children and adults. The etiology is multifactorial with the contribution of genetic, immune, microbial, and environmental risk factors with a substanti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14ad3ec88c433c9ad947d50ee2c31cb0
https://doi.org/10.1101/2022.03.17.22271929

Bioengineering of functional human induced pluripotent stem cell-derived intestinal grafts

Autor: Sarah E. Gilpin, Allan M. Goldstein, Dana M. Schwartz, Cesar Sommer, Amalia Capilla, Harald C. Ott, Douglas J. Mathisen, Gustavo Mostoslavsky, Gregory R. Wojtkiewicz, Kentaro Kitano, Haiyang Zhou, Xi Ren

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Kitano, K; Schwartz, DM; Zhou, H; Gilpin, SE; Wojtkiewicz, GR; Ren, X; et al.(2017). Bioengineering of functional human induced pluripotent stem cell-derived intestinal grafts. Nature Communications, 8(1). doi: 10.1038/s41467-017-00779-y. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/7811z3rj
Nature Communications

Patients with short bowel syndrome lack sufficient functional intestine to sustain themselves with enteral intake alone. Transplantable vascularized bioengineered intestine could restore nutrient absorption. Here we report the engineering of humanize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccbe321a332ea16d6e56f9da1fdc2c3f
http://link.springer.com/article/10.1038/s41467-017-00779-y

Increased prevalence of pathogenic bacteria in the gut microbiota of infants at risk of developing celiac disease: The PROFICEL study

Autor: Luis Ortigosa, Francesc Palau, Amalia Capilla, Carmen Ribes-Koninckx, Vicente Varea, Gemma Castillejo, Ester Donat, Alfonso Benítez-Páez, Esther Nova, Yolanda Sanz, C. Calvo, José Antonio Garrote, Giada De Palma, Ascensión Marcos, Marta Olivares, Isabel Polanco

Publikováno v: Gut Microbes
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
Digital.CSIC. Repositorio Institucional del CSIC
instname
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Gut microbes
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu

8 páginas, 1 figura, 2 tablas
Celiac disease (CD) is an immune-mediated enteropathy involving genetic and environmental factors, whose interaction influences disease risk. The intestinal microbiota, including viruses and bacteria, could play a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0decfd4bbba6059820d01f1476ee2012
http://fundanet.fsjd.org/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16466