Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Amalia Bosia"'
Autor:
Chiara Riganti, Barbara Castella, Joanna Kopecka, Ivana Campia, Marta Coscia, Gianpiero Pescarmona, Amalia Bosia, Dario Ghigo, Massimo Massaia
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60975 (2013)
Durable tumor cell eradication by chemotherapy is challenged by the development of multidrug-resistance (MDR) and the failure to induce immunogenic cell death. The aim of this work was to investigate whether MDR and immunogenic cell death share a com
Externí odkaz:
https://doaj.org/article/e5c66e89e2554cf99103ab0df62d0f10
Autor:
Amalia Bosia, Iris Chiara Salaroglio, Marta Mellai, Dario Ghigo, Joanna Kopecka, Valentina Caldera, Davide Schiffer, Laura Annovazzi, Ivana Campia, Chiara Riganti
Publikováno v:
Neuro-Oncology. 15:1502-1517
Glioblastoma multiforme (GBM) is the most malignant and frequent intra-axial tumor of the central nervous system. Despite improvements in neurosurgery, radiotherapy, and chemotherapy, no local control of the disease is today possible.1,2 The failure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ac702fba0e1325455df5e9dc82e381
https://doi.org/10.1093/neuonc/not104
https://doi.org/10.1093/neuonc/not104
Autor:
Ignacio-Andres Romero, P.O. Couraud, Chiara Riganti, Ruth Garzón, Dario Antonio Ghigo, Martha L. Pinzon-Daza, Babette B. Weksler, Amalia Bosia
Publikováno v:
British Journal of Pharmacology. 167:1431-1447
BACKGROUND AND PURPOSE The passage of drugs across the blood–brain barrier (BBB) limits the efficacy of chemotherapy in brain tumours. For instance, the anticancer drug doxorubicin, which is effective against glioblastoma in vitro, has poor efficac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c769e6f9e085f88d94c1d3789482138
https://doi.org/10.1111/j.1476-5381.2012.02103.x
https://doi.org/10.1111/j.1476-5381.2012.02103.x
Autor:
Amalia Bosia, Elisabetta Bolli, Hedwige Pinto, Federica Cavallo, Chiara Riganti, Raffaele A. Calogero, Dimas Carolina Belisario
Publikováno v:
Biochemical Pharmacology. 82:1079-1089
The widely used anticholesterolemic drugs statins decrease the synthesis of cholesterol and the isoprenylation and activity of small G-proteins such as Ras and Rho, the effectors of which are often critical in cell proliferation. Thanks to this prope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47462a9e73ef35becbb812a39bab2309
https://doi.org/10.1016/j.bcp.2011.07.079
https://doi.org/10.1016/j.bcp.2011.07.079
Autor:
Ivana Campia, Dario Ghigo, Chiara Riganti, Davide Brusa, Sophie Doublier, Joanna Kopecka, Amalia Bosia, Lina Matera
Publikováno v:
Journal of Cellular and Molecular Medicine
The anticancer drug doxorubicin induces the synthesis of nitric oxide, a small molecule that enhances the drug cytotoxicity and reduces the drug efflux through the membrane pump P-glycoprotein (Pgp). Doxorubicin also induces the translocation on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8f9bde5c3e0da66c0a20017ed99f96a
https://doi.org/10.1111/j.1582-4934.2010.01137.x
https://doi.org/10.1111/j.1582-4934.2010.01137.x
Autor:
Ivana Campia, Stefano Guglielmo, Chiara Riganti, Amalia Bosia, Konstantin Chegaev, Barbara Rolando, Loretta Lazzarato, Alberto Gasco, Roberta Fruttero
Publikováno v:
ACS Medicinal Chemistry Letters. 2:494-497
Products 4 and 5, obtained by conjugation of doxorubicin with nitric oxide (NO) donor nitrooxy and phenylsulfonyl furoxan moieties, respectively, accumulate in doxorubicin-resistant human colon cancer cells (HT29-dx), inducing high cytotoxicity. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99eb33c616abd7aef8cf1178b8461d13
https://doi.org/10.1021/ml100302t
https://doi.org/10.1021/ml100302t
Autor:
Silvia Peola, Myriam Foglietta, Francesca Pantaleoni, Valentina Griggio, Chiara Riganti, Marta Coscia, Micol Maria Rigoni, Barbara Castella, Amalia Bosia, Candida Vitale, Daniela Drandi, Massimo Massaia, Marco Ladetto, Mario Boccadoro
Publikováno v:
Leukemia. 25:828-837
Tumor cells in chronic lymphocytic leukemia (CLL) are more prone to apoptosis when cultured ex vivo, because they lack prosurvival signals furnished in vivo via B-cell receptor (BCR)-dependent and -independent pathways. This study compared the suscep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de4550e336ebf73855200c6a2cc0aec
https://doi.org/10.1038/leu.2011.12
https://doi.org/10.1038/leu.2011.12
Autor:
Dario Ghigo, Loredana Bergandi, E. Aldieri, Costanzo Costamagna, Elena Gazzano, Amalia Bosia, Sophie Doublier, Chiara Riganti
Publikováno v:
Current Medicinal Chemistry. 17:2431-2441
The behavior of fluoride ions in the human organism is a classic example of double-edged sword. On the one hand the daily supplementation with fluoride is undoubtedly an important preventing factor in protecting teeth from caries, and, as an importan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bec68e33c20ee20618540c67ec292cbd
https://doi.org/10.2174/092986710791698503
https://doi.org/10.2174/092986710791698503
Autor:
Dario Ghigo, Elena Gazzano, Alberto Revelli, Alessia Cipriani, Cinzia Racca, Cristina Lussiana, Daniele Viarisio, Erica Miraglia, Amalia Bosia
Publikováno v:
Fertility and Sterility. 93:2437-2440
In swim-up-selected spermatozoa of 38 normozoospermic patients, capacitated spermatozoa exhibited enhanced pentose phosphate pathway (PPP) activity and increased expression of glucose-6-phosphate dehydrogenase (G6PD). The G6PD inhibitor DHEA and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8148b8b56f35f9c280f137326b445f0f
https://doi.org/10.1016/j.fertnstert.2009.09.005
https://doi.org/10.1016/j.fertnstert.2009.09.005
Publikováno v:
British Journal of Pharmacology. 158:1777-1786
Background and purpose: Statins, inhibitors of hydroxymethylglutaryl-CoA reductase, reduce the intracellular synthesis of cholesterol and prevent the onset of atherosclerosis. They also decrease the synthesis of isoprenoid molecules, such as the side
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3630cd55eb59de386f674a81cdc8d8d
https://doi.org/10.1111/j.1476-5381.2009.00465.x
https://doi.org/10.1111/j.1476-5381.2009.00465.x