Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Amaleah A. Hartman"'
Autor:
Xinyue Chen, Daniel B. Burkhardt, Amaleah A. Hartman, Xiao Hu, Anna E. Eastman, Chao Sun, Xujun Wang, Mei Zhong, Smita Krishnaswamy, Shangqin Guo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Not all mutated cells become malignant, suggesting additional requirements for transformation. Here, the authors track blood progenitors from normal to malignancy driven by MLL-AF9, revealing a subset of myeloid progenitors predisposed to transformat
Externí odkaz:
https://doaj.org/article/b111a4d94fc0407fb663f8993929840c
Autor:
Xiao Hu, Zongzhi Z. Liu, Xinyue Chen, Vincent P. Schulz, Abhishek Kumar, Amaleah A. Hartman, Jason Weinstein, Jessica F. Johnston, Elisa C. Rodriguez, Anna E. Eastman, Jijun Cheng, Liz Min, Mei Zhong, Christopher Carroll, Patrick G. Gallagher, Jun Lu, Martin Schwartz, Megan C. King, Diane S. Krause, Shangqin Guo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
MKL1 is a key transcriptional co-activator of actin cytoskeleton genes. Here the authors show that MKL1 activation in somatic cells reduces chromatin accessibility and hinders full reprogramming to pluripotency. Reduction of MKL1, disruption of actin
Externí odkaz:
https://doaj.org/article/39034a1a1b414222967219825619062a
Autor:
Xinyue Chen, Daniel B. Burkhardt, Amaleah A. Hartman, Xiao Hu, Anna E. Eastman, Chao Sun, Xujun Wang, Mei Zhong, Smita Krishnaswamy, Shangqin Guo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/a24c448059824d568b0ffb1c4dc19226
Autor:
Xinyue Chen, Anna E. Eastman, In-Hyun Park, Amaleah A. Hartman, Xiao Hu, Qiao Wu, Jonghun Kim, Jian Zhang, Shangqin Guo
Publikováno v:
Stem Cells (Dayton, Ohio)
There is wide variability in the propensity of somatic cells to reprogram into pluripotency in response to the Yamanaka factors. How to segregate these variabilities to enrich for cells of specific traits that reprogram efficiently remains challengin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd170abeca35b447a14b69e2604c2fee
https://doi.org/10.1002/stem.3295
https://doi.org/10.1002/stem.3295
Autor:
Anna E. Eastman, Daniel B. Burkhardt, Chao Sun, Xinyue Chen, Xiao Hu, Shangqin Guo, Amaleah A. Hartman, Mei Zhong, Xujun Wang, Smita Krishnaswamy
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
Cancer is a hyper-proliferative disease. Whether the proliferative state originates from the cell-of-origin or emerges later remains difficult to resolve. By tracking de novo transformation from normal hematopoietic progenitors expressing an acute my
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a94786e720d9cb2fa70cbbfa3219060e
http://link.springer.com/article/10.1038/s41467-019-13666-5
http://link.springer.com/article/10.1038/s41467-019-13666-5
Autor:
Chao Sun, Xiao Hu, Mei Zhong, Anna E. Eastman, Shangqin Guo, Xujun Wang, Amaleah A. Hartman, Smita Krishnaswamy, Xinyue Chen, Daniel B. Burkhardt
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
Cancer is a hyper-proliferative disease. Whether the proliferative state originates from the cell-of-origin or emerges later remains difficult to resolve. By tracking de novo transformation from normal hematopoietic progenitors expressing an acute my
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95e39caf4a75c1eadcb379a062b6e40
https://doi.org/10.1038/s41467-020-14428-4
https://doi.org/10.1038/s41467-020-14428-4
Autor:
Amaleah A. Hartman, S. Maxwell Scalf, Xiao Hu, Jian Zhang, Shangqin Guo, Xinyue Chen, Anna E. Eastman, Cindy Yang
Publikováno v:
Stem Cell Reports
Summary Yes-associated protein (YAP) is known to promote the stemness of multiple stem cell types, including pluripotent stem cells, while also antagonizing pluripotency during early embryogenesis. How YAP accomplishes these distinct functions remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c7d290f689b5a55cf70500b8c9aba3
https://pubmed.ncbi.nlm.nih.gov/32243844
https://pubmed.ncbi.nlm.nih.gov/32243844
Autor:
Martin A. Schwartz, Xiao Hu, Anna E. Eastman, Xinyue Chen, Jason S. Weinstein, Megan C. King, Elisa C. Rodriguez, Christopher W. Carroll, Liz Min, Mei Zhong, Zongzhi Liu, Patrick G. Gallagher, Shangqin Guo, Jijun Cheng, Jun Lu, Abhishek Kumar, Jessica F. Johnston, Amaleah A. Hartman, Vincent P. Schulz, Diane S. Krause
Publikováno v:
Nature Communications
Hu, X, Liu, Z Z, Chen, X, Schulz, V P, Kumar, A, Hartman, A A, Weinstein, J, Johnston, J F, Rodriguez, E C, Eastman, A E, Cheng, J, Min, L, Zhong, M, Carroll, C, Gallagher, P G, Lu, J, Schwartz, M, King, M C, Krause, D S & Guo, S 2019, ' MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation ', Nature Communications, vol. 10, no. 1, 1695 . https://doi.org/10.1038/s41467-019-09636-6
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Hu, X, Liu, Z Z, Chen, X, Schulz, V P, Kumar, A, Hartman, A A, Weinstein, J, Johnston, J F, Rodriguez, E C, Eastman, A E, Cheng, J, Min, L, Zhong, M, Carroll, C, Gallagher, P G, Lu, J, Schwartz, M, King, M C, Krause, D S & Guo, S 2019, ' MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation ', Nature Communications, vol. 10, no. 1, 1695 . https://doi.org/10.1038/s41467-019-09636-6
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Actin cytoskeleton is well-known for providing structural/mechanical support, but whether and how it regulates chromatin and cell fate reprogramming is far less clear. Here, we report that MKL1, the key transcriptional co-activator of many actin cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6fa88ee3a24806839b2d36622ff574
https://doi.org/10.1038/s41467-019-09636-6
https://doi.org/10.1038/s41467-019-09636-6
Autor:
Xiao Hu, Shangqin Guo, Cindy Yang, Jun Lu, Anna E. Eastman, Aria M. Pearlman Morales, Xinyue Chen, Hao Yuan Kueh, Amaleah A. Hartman
Publikováno v:
Cell reports
SUMMARY Cell proliferation changes concomitantly with fate transitions during reprogramming, differentiation, regeneration, and oncogenesis. Methods to resolve cell cycle length heterogeneity in real time are currently lacking. Here, we describe a ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ab2a05f6220560a5d5c473ec65034a5
Autor:
Xiao Hu, Xinyue Chen, Anna E. Eastman, Amaleah A. Hartman, Shangqin Guo, Mei Zhong, Xujun Wang
Cancer is a hyper-proliferative clonal disease. Whether the proliferative state originates from the cell-of-origin or emerges later remains elusive. By tracking de novo transformation from normal hematopoietic progenitors expressing an acute myeloid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1df417d02c8a643c7cddeffac76034b