Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Amale Hawi"'
Publikováno v:
Metabolites, Vol 14, Iss 9, p 471 (2024)
Nalbuphine (NAL) is a mixed κ-agonist/μ-antagonist opioid with extensive first-pass metabolism. A phase 1 open-label study was conducted to characterize the pharmacokinetics (PKs) of NAL and select metabolites following single oral doses of NAL ext
Externí odkaz:
https://doaj.org/article/a2246a2e93ae4384bca4a04e32f3edc8
Publikováno v:
British Journal of Clinical Pharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e8e83d6fe637612a165824e17ffc36e
https://doi.org/10.1111/bcp.15663
https://doi.org/10.1111/bcp.15663
Population pharmacokinetic (PK) and pharmacokinetic- pharmacodynamic (PK-PD) models were used to quantify the exposure-response (E-R) relationship between nalbuphine exposure and 2 widely used rating scales for itch: the Numerical Rating Scale for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d65659c821ab60205d63bd855b9d4d69
https://doi.org/10.22541/au.166177100.03899983/v1
https://doi.org/10.22541/au.166177100.03899983/v1
Autor:
William D. Shrader, Steven M. Willi, Amale Hawi, M. Grazia Cotticelli, Eric Deutsch, Karlla W. Brigatti, Patrice Rioux, Olena Kucheruk, Guy M. Miller, Thomas Sciascia, David A. Lynch, Robert B. Wilson
Publikováno v:
Movement Disorders. 27:1026-1033
This study tested the ability of A0001 (α-tocopheryl quinone; EPI-A0001), a potent antioxidant, to improve in vitro measures, glucose metabolism, and neurological function in Friedreich ataxia. We used an in vitro study of protection from cell toxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f4fe4d22f3e05c6f38a16474727fe7b
https://doi.org/10.1002/mds.25058
https://doi.org/10.1002/mds.25058
Publikováno v:
BMC Nephrology
Background Uremic pruritus is a common and deleterious condition among hemodialysis (HD) patients. Central gating of μ/κ opiate circuitry plays an important role in mediating and countering pruritogenic sensation. The objective of this study was to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9850fa5bface603bdf07cde5b266d69e
https://pubmed.ncbi.nlm.nih.gov/25885112
https://pubmed.ncbi.nlm.nih.gov/25885112
Autor:
David R, Lynch, Steven M, Willi, Robert B, Wilson, M Grazia, Cotticelli, Karlla W, Brigatti, Eric C, Deutsch, Olena, Kucheruk, William, Shrader, Patrice, Rioux, Guy, Miller, Amale, Hawi, Thomas, Sciascia
Publikováno v:
Movement disorders : official journal of the Movement Disorder Society. 27(8)
This study tested the ability of A0001 (α-tocopheryl quinone; EPI-A0001), a potent antioxidant, to improve in vitro measures, glucose metabolism, and neurological function in Friedreich ataxia. We used an in vitro study of protection from cell toxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7e8d31a1b089c962f36e59e6170b94ae
https://pubmed.ncbi.nlm.nih.gov/22744651
https://pubmed.ncbi.nlm.nih.gov/22744651
Publikováno v:
Journal of clinical pharmacology. 52(1)
A0001 (α-tocopherylquinone) is a potent antioxidant currently in development for the treatment of symptoms associated with inherited mitochondrial disorders. A0001 pharmacokinetics were studied in a single-blind, adaptive design study following a si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a68218161a8926c466386bd0427f14ac
https://pubmed.ncbi.nlm.nih.gov/21343342
https://pubmed.ncbi.nlm.nih.gov/21343342
Publikováno v:
Journal of the Chemical Society, Chemical Communications. :283
Acid-catalysed decomposition of (4′-azidophenyl)propanoic and butyric acids leads to ipso-attack by the carboxy group para to the nitrenium ion and the formation of imines of cyclohexadienone spiro-lactones, which can rearrange to the benz-fused la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00ab1d55fe882fbca23522d6592d4f68
https://doi.org/10.1039/c39860000283
https://doi.org/10.1039/c39860000283