Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Amal Senevirathne"'
Publikováno v:
Engineering, Vol 32, Iss , Pp 41-56 (2024)
A universal vaccine is in high demand to address the uncertainties of antigenic drift and the reduced effectiveness of current influenza vaccines. In this study, a strategy called computationally optimized broadly reactive antigen (COBRA) was used to
Externí odkaz:
https://doaj.org/article/dbc7803b0e3a4568b418c56fc5487bb2
Autor:
Perumalraja Kirthika, Amal Senevirathne, Sungwoo Park, Ram Prasad Aganja, In-Shik Kim, Hyun-Jin Tae, John Hwa Lee
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 9056 (2024)
In the current study, two Salmonella Typhimurium strains, JOL 912 and JOL 1800, were engineered from the wild-type JOL 401 strain through in-frame deletions of the lon and cpxR genes, with JOL 1800 also lacking rfaL. These deletions significantly att
Externí odkaz:
https://doaj.org/article/475854fe77bc4ec897bd9dcb36322c1c
Autor:
Amal Senevirathne, Irshad A. Hajam
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 1, Pp 102089- (2024)
Externí odkaz:
https://doaj.org/article/d051b8d1c71047fbb9ac65f3d443a239
Publikováno v:
Poultry Science, Vol 103, Iss 2, Pp 103354- (2024)
ABSTRACT: In this study, we incorporated deletion of the O-antigen ligase gene to an attenuated Salmonella Enteritidis (SE) strain, JOL919 (SE PS; Δlon ΔcpxR), using the Lambda-Red recombination method and evaluated the safety and immunological asp
Externí odkaz:
https://doaj.org/article/047c1cb6cb404fff878d08ebad8cf481
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6394 (2024)
In our prior investigations, we elucidated the role of the tryptophan-to-tyrosine substitution at the 61st position in the nonstructural protein NSsW61Y in diminishing the interaction between nonstructural proteins (NSs) and nucleoprotein (NP), imped
Externí odkaz:
https://doaj.org/article/9abc69f02420449db414b3762f4f25dd
Publikováno v:
Pharmaceutics, Vol 15, Iss 10, p 2462 (2023)
This study investigates the anticancer properties of the α7-nAChR antagonist SLURP1 with a specific focus on its effect as an inflammation modulator on human colorectal cancer cell lines Caco2, Colo320DM, and H508 cells. The investigation includes t
Externí odkaz:
https://doaj.org/article/db76e39aa9e14a00af4bca99d44e82ca
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
This study investigates the interplay between Lon protease and catalase-peroxidase (KatG) in relation to virulence modulation and the response to oxidative stress in Salmonella Typhimurium (ST). Proteomic comparison of ST wild-type and lon deletion m
Externí odkaz:
https://doaj.org/article/cf257c158ed24c249f0a485920dc2cac
Publikováno v:
Veterinary Research, Vol 52, Iss 1, Pp 1-16 (2021)
Abstract Efficient in vivo delivery of a CRISPR/Cas9 plasmid is of paramount importance for effective therapy. Here, we investigated the usability of Salmonella as a plasmid carrier for in vivo therapy against virus-induced cancer using Marek’s dis
Externí odkaz:
https://doaj.org/article/319284f590a84f63afcda625dc213019
Autor:
Amal Senevirathne, E. H. T. Thulshan Jayathilaka, D. K. Haluwana, Kiramage Chathuranga, Mahinda Senevirathne, Ji-Soo Jeong, Tae-Won Kim, Jong-Soo Lee, Mahanama De Zoysa
Publikováno v:
Viruses, Vol 15, Iss 6, p 1375 (2023)
This study investigated the antiviral activity of aqueous leaf extract of Costus speciosus (TB100) against influenza A. Pretreatment of TB100 in RAW264.7 cells enhanced antiviral activity in an assay using the green fluorescence-expressing influenza
Externí odkaz:
https://doaj.org/article/0a61770e31b04bcd852d63fe7e47cdb5
Publikováno v:
Gut Microbes, Vol 11, Iss 6, Pp 1695-1712 (2020)
In the present study, we characterized the involvement of Lon protease in bacterial virulence and intracellular survival in Salmonella under abiotic stress conditions resembling the conditions of a natural infection. Wild type (JOL401) and the lon mu
Externí odkaz:
https://doaj.org/article/fdc4feb7f19a40ea9b1d3892e107ac52