Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Amal Rahmeh"'
Autor:
Maria Pallarès-Masmitjà, Dimitrije Ivančić, Júlia Mir-Pedrol, Jessica Jaraba-Wallace, Tommaso Tagliani, Baldomero Oliva, Amal Rahmeh, Avencia Sánchez-Mejías, Marc Güell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Mammalian genome engineering has advanced tremendously over the last decade, however there is still a need for robust gene writing with size scaling capacity. Here the authors present Find Cut-and-Transfer (FiCAT) technology to delivery large targete
Externí odkaz:
https://doaj.org/article/c23e566832b248cfab7f31975632a946
Autor:
Dimitrije Ivančić, Jessica Jaraba-Wallace, Amal Rahmeh, Tommaso Tagliani, Baldomero Oliva, Maria Pallarès-Masmitjà, Marc Güell, Júlia Mir-Pedrol, Avencia Sánchez-Mejías
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
While multiple technologies for small allele genome editing exist, robust technologies for targeted integration of large DNA fragments in mammalian genomes are still missing. Here we develop a gene delivery tool (FiCAT) combining the precision of a C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::565e456fa97f5e00d171e10adb59bca1
https://doi.org/10.1038/s41467-021-27183-x
https://doi.org/10.1038/s41467-021-27183-x
Autor:
Ana De Almeida, Judy Jacques, Jacqueline Hewett, Mitchel H. Finer, Amal Rahmeh, Edward M. Kennedy, Lorena Lerner, Jennifer Lee, Danielle Douglas, Brian B. Haines, Lauren Herschelman, Sonia Feau, Lingxin Kong, Matt Scott, Melissa Hayes, Christophe Quéva, Sanmit Adhikari, Jessica Deterling, Jacob Spinale, Jeffrey Bryant, Agnieszka Denslow, Elizabeth McMichael, Ted Ashburn
Oncolytic viruses (OVs) are an emerging therapeutic approach for the treatment of cancer. Clinical benefit has been demonstrated for intratumoral administration, but the therapeutic effectiveness of intravenous delivery has been limited by neutralizi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69f2c6ae8f6099221e993d23ed04163e
https://doi.org/10.21203/rs.3.rs-523458/v1
https://doi.org/10.21203/rs.3.rs-523458/v1
Publikováno v:
Biochemistry. 51:416-424
DNA polymerase delta (Pol δ) is a central enzyme for eukaryotic DNA replication and repair. Pol δ is a complex of four subunits p125, p68, p50, and p12. The functional properties of Pol δ are largely determined by its interaction with its DNA slid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c1e23cf34cc881b80e5d6602dc1b646
https://doi.org/10.1021/bi201638e
https://doi.org/10.1021/bi201638e
Autor:
Ghassan Dbaibo, Mohamad A. Mikati, Marwan El Sabban, Julnar Usta, Michele Zeinieh, Ralph Abi Habib, Amal Rahmeh, Jimmy El Hokayem
Publikováno v:
Epilepsy Research. 81:161-166
Status epilepticus (SE) induces a number of events leading to programmed cell death (PCD). The aim of our work is to study the time sequence of activation of different factors in experimental SE (intraperitoneal kainic acid (KA) model). We studied ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::067fedaf43727180d3bf94483c086f63
https://doi.org/10.1016/j.eplepsyres.2008.05.009
https://doi.org/10.1016/j.eplepsyres.2008.05.009
Autor:
Zhongtao Zhang, Rong Zheng, Szu Hua Sharon Lin, Xiaoxiao Wang, Fu Yue, Amal Rahmeh, Sufang Zhang, Marietta Y.W.T. Lee, Ernest Y.C. Lee
Publikováno v:
Oncotarget
// Xiaoxiao Wang 1,* , Sufang Zhang 1,* , Rong Zheng 1 , Fu Yue 1 , Szu Hua Sharon Lin 1 , Amal A. Rahmeh 1 , Ernest Y.C. Lee 1 , Zhongtao Zhang 1 and Marietta Y.W.T. Lee 1 1 Department of Biochemistry and Molecular Biology, New York Medical College,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e49471ee46b6039ea5dbfeb28705bea8
https://pubmed.ncbi.nlm.nih.gov/26819372
https://pubmed.ncbi.nlm.nih.gov/26819372
Autor:
Sandra Trusa, Marietta Y.W.T. Lee, Yan Gao, Yajing Zhou, Bin Xie, Ernest Y.C. Lee, Sufang Zhang, Amal Rahmeh, Hao Li
Publikováno v:
Journal of Biological Chemistry. 281:14748-14755
Mammalian DNA polymerase delta (pol delta), a key enzyme of chromosomal DNA replication, consists of four subunits as follows: the catalytic subunit; p125, which is tightly associated with the p50 subunit; p68, a proliferating cell nuclear antigen (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c06c76af43f0967d1f64f573f3c060
https://doi.org/10.1074/jbc.m600322200
https://doi.org/10.1074/jbc.m600322200
Publikováno v:
Cell Cycle. 5:428-436
Using a yeast two-hybrid screening technique and the p50 subunit of human DNA polymerase delta (pol delta) as a bait, p21 was found to interact with the p50 subunit of pol delta. A direct interaction between p21 and p50 was confirmed by using ELISA a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed5bee649d07848d16053edb38434c6
https://doi.org/10.4161/cc.5.4.2425
https://doi.org/10.4161/cc.5.4.2425
Publikováno v:
Journal of Biological Chemistry. 280:22375-22384
Polymerase delta interacting protein 38 (PDIP38) was identified as a human DNA polymerase (pol) delta interacting protein through a direct interaction with p50, the small subunit of human pol delta. PDIP38 was also found to interact with proliferatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::551f17eadf5292be8f4bb60039e46502
https://doi.org/10.1074/jbc.m414597200
https://doi.org/10.1074/jbc.m414597200
Publikováno v:
Biochemistry. 41:13133-13142
Mammalian DNA polymerase delta was originally characterized as a tightly associated heterodimer consisting of the catalytic subunit, p125, and the p50 subunit. Recently, two additional subunits, the third (p68) and fourth subunits (p12), have been id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e696d542cae6886004b066bcd561b209
https://doi.org/10.1021/bi0262707
https://doi.org/10.1021/bi0262707