Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Amal O Amer"'
Autor:
Samuel Speaks, Matthew I. McFadden, Ashley Zani, Abigail Solstad, Steve Leumi, Jack E. Roettger, Adam D. Kenney, Hannah Bone, Lizhi Zhang, Parker J. Denz, Adrian C. Eddy, Amal O. Amer, Richard T. Robinson, Chuanxi Cai, Jianjie Ma, Emily A. Hemann, Adriana Forero, Jacob S. Yount
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Influenza virus activates cellular inflammasome pathways, which can be both beneficial and detrimental to infection outcomes. Here, we investigate the function of the inflammasome-activated, pore-forming protein gasdermin D (GSDMD) during in
Externí odkaz:
https://doaj.org/article/1bdb4d643c5340eaab89b6eb41184ba9
Autor:
Kylene P. Daily, Asmaa Badr, Mostafa Eltobgy, Shady Estfanous, Owen Whitham, Michelle H. Tan, Cierra Carafice, Kathrin Krause, Andrew McNamara, Kaitlin Hamilton, Samuel Houle, Spandan Gupta, Gauruv A. Gupta, Shruthi Madhu, Julie Fitzgerald, Abbey A. Saadey, Brooke Laster, Pearlly Yan, Amy Webb, Xiaoli Zhang, Maciej Pietrzak, Olga N. Kokiko-Cochran, Hazem E. Ghoneim, Amal O. Amer
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-20 (2024)
Abstract Alzheimer’s disease (AD) is the sixth leading cause of death in the USA. It is established that neuroinflammation contributes to the synaptic loss, neuronal death, and symptomatic decline of AD patients. Accumulating evidence suggests a cr
Externí odkaz:
https://doaj.org/article/e9004d48993349bc9f739f58c680a79a
Autor:
Shady Estfanous, Kathrin Krause, Midhun N. K. Anne, Mostafa Eltobgy, Kyle Caution, Arwa Abu Khweek, Kaitlin Hamilton, Asmaa Badr, Kylene Daily, Cierra Carafice, Daniel Baetzhold, Xiaoli Zhang, Tianliang Li, Haitao Wen, Mikhail A. Gavrilin, Hesham Haffez, Sameh Soror, Amal O. Amer
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Abstract Burkholderia cenocepacia (B. cenocepacia) is an opportunistic bacterium; causing severe life threatening systemic infections in immunocompromised individuals including cystic fibrosis patients. The lack of gasdermin D (GSDMD) protects mice a
Externí odkaz:
https://doaj.org/article/dfc42d70a6394957ad2316ed4514e290
Autor:
Shady Estfanous, Kathrin Krause, Midhun N. K. Anne, Mostafa Eltobgy, Kyle Caution, Arwa Abu Khweek, Kaitlin Hamilton, Asmaa Badr, Kylene Daily, Cierra Carafice, Daniel Baetzhold, Xiaoli Zhang, Tianliang Li, Haitao Wen, Mikhail A. Gavrilin, Hesham Haffez, Sameh Soror, Amal O. Amer
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-3 (2021)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/cfdde74256e840cda4a31d10563b25fc
Autor:
Asmaa Badr, Mostafa Eltobgy, Kathrin Krause, Kaitlin Hamilton, Shady Estfanous, Kylene P. Daily, Arwa Abu Khweek, Ahmad Hegazi, Midhun N. K. Anne, Cierra Carafice, Frank Robledo-Avila, Youssra Saqr, Xiaoli Zhang, Tracey L. Bonfield, Mikhail A. Gavrilin, Santiago Partida-Sanchez, Stephanie Seveau, Estelle Cormet-Boyaka, Amal O. Amer
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Cystic fibrosis (CF) human and mouse macrophages are defective in their ability to clear bacteria such as Burkholderia cenocepacia. The autophagy process in CF (F508del) macrophages is halted, and the underlying mechanism remains unclear. Furthermore
Externí odkaz:
https://doaj.org/article/db95827f79284dbaa804f925acce7f81
Autor:
Amelia Staats, Peter W. Burback, Mostafa Eltobgy, Dana M. Parker, Amal O. Amer, Daniel J. Wozniak, Shu-Hua Wang, Kurt B. Stevenson, Kenneth L. Urish, Paul Stoodley
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 2 (2021)
ABSTRACT Rapid synovial fluid-induced aggregation of Staphylococcus aureus is currently being investigated as an important factor in the establishment of periprosthetic joint infections (PJIs). Pathogenic advantages of aggregate formation have been w
Externí odkaz:
https://doaj.org/article/ddbe2640325f456b9458e995c5267f09
Autor:
Shady Estfanous, Kylene P. Daily, Mostafa Eltobgy, Nicholas P. Deems, Midhun N. K. Anne, Kathrin Krause, Asmaa Badr, Kaitlin Hamilton, Cierra Carafice, Ahmad Hegazi, Arwa Abu Khweek, Hesham Kelani, Shahid Nimjee, Hamdy Awad, Xiaoli Zhang, Estelle Cormet-Boyaka, Hesham Haffez, Sameh Soror, Adel Mikhail, Gerard Nuovo, Ruth M. Barrientos, Mikhail A. Gavrilin, Amal O. Amer
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Autophagy is a proposed route of amyloid-β (Aβ) clearance by microglia that is halted in Alzheimer’s Disease (AD), though mechanisms underlying this dysfunction remain elusive. Here, primary microglia from adult AD (5xFAD) mice were utilized to d
Externí odkaz:
https://doaj.org/article/a9bb136f3f4c4634b5d53a535a5644ae
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The prevalence of asthma has been rising steadily for several decades, and continues to be a major public health and global economic burden due to both direct and indirect costs. Asthma is defined as chronic heterogeneous inflammatory diseases charac
Externí odkaz:
https://doaj.org/article/96a2fe305e4740fbb3712aee0edfccd2
Autor:
Kyle Jablonski, Nicholas A Young, Caitlin Henry, Kyle Caution, Anuradha Kalyanasundaram, Ifeoma Okafor, Peter Harb, Emmy Schwarz, Paul Consiglio, Chris M Cirimotich, Anna Bratasz, Anasuya Sarkar, Amal O Amer, Wael N Jarjour, Naomi Schlesinger
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0237520 (2020)
ObjectivesGout is the most prevalent inflammatory arthritis. To study the effects of regular physical activity and exercise intensity on inflammation and clinical outcome, we examined inflammatory pathogenesis in an acute model of murine gout and ana
Externí odkaz:
https://doaj.org/article/81b2378e9ff54aebbab0ff7b32af637d