Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Amal M. Sahyoun"'
1
Akademický článek
The Beneficial Effect of Lomitapide on the Cardiovascular System in LDLr−/− Mice with Obesity
Autor: Undral Munkhsaikhan, Young In Kwon, Amal M. Sahyoun, María Galán, Alexis A. Gonzalez, Karima Ait-Aissa, Ammaar H. Abidi, Adam Kassan, Modar Kassan
Publikováno v: Antioxidants, Vol 12, Iss 6, p 1287 (2023)
Objectives: Homozygous familial hypercholesteremia (HoFH) is a rare, life-threatening metabolic disease, mainly caused by a mutation in the LDL receptor. If untreated, HoFH causes premature death from acute coronary syndrome. Lomitapide is approved b
Externí odkaz: https://doaj.org/article/a7c38969a08a46858fe0bd9ead16100e
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2
Akademický článek
MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy
Autor: Karima Ait-Aissa, Quynh My Nguyen, Mohanad Gabani, Adam Kassan, Santosh Kumar, Soo-Kyoung Choi, Alexis A. Gonzalez, Tahsin Khataei, Amal M. Sahyoun, Cheng Chen, Modar Kassan
Publikováno v: Cardiovascular Diabetology, Vol 19, Iss 1, Pp 1-26 (2020)
Abstract The endothelium plays a pivotal role in maintaining vascular health. Obesity is a global epidemic that has seen dramatic increases in both adult and pediatric populations. Obesity perturbs the integrity of normal endothelium, leading to endo
Externí odkaz: https://doaj.org/article/e41916ad23f04d7ab421d60fe1fd4f6c
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3
Akademický článek
Protective Role of Short-Chain Fatty Acids against Ang- II-Induced Mitochondrial Dysfunction in Brain Endothelial Cells: A Potential Role of Heme Oxygenase 2
Autor: Modar Kassan, Youngin Kwon, Undral Munkhsaikhan, Amal M. Sahyoun, Tauheed Ishrat, María Galán, Alexis A. Gonzalez, Ammaar H. Abidi, Adam Kassan, Karima Ait-Aissa
Publikováno v: Antioxidants, Vol 12, Iss 1, p 160 (2023)
Objectives: Short-chain fatty acids (SCFAs), the main metabolites released from the gut microbiota, are altered during hypertension and obesity. SCFAs play a beneficial role in the cardiovascular system. However, the effect of SCFAs on cerebrovascula
Externí odkaz: https://doaj.org/article/729830134052436ea959c4694693e885
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4
The Beneficial Effect of Lomitapide on the Cardiovascular System in LDLr−/− Mice with Obesity
Autor: Kassan, Undral Munkhsaikhan, Young In Kwon, Amal M. Sahyoun, María Galán, Alexis A. Gonzalez, Karima Ait-Aissa, Ammaar H. Abidi, Adam Kassan, Modar
Publikováno v: Antioxidants; Volume 12; Issue 6; Pages: 1287
Objectives: Homozygous familial hypercholesteremia (HoFH) is a rare, life-threatening metabolic disease, mainly caused by a mutation in the LDL receptor. If untreated, HoFH causes premature death from acute coronary syndrome. Lomitapide is approved b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::d8f1dfd57e6ed78ffbc330a7a11b9b8b
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5
The microsomal triglyceride transfer protein inhibitor lomitapide improves vascular function in mice with obesity
Autor: Undral Munkhsaikhan, Youngin Kwon, Amal M. Sahyoun, Karima Ait‐Aissa, Adam Kassan, Modar Kassan
Publikováno v: Obesity (Silver Spring)
OBJECTIVES: In this study, we investigate the effect of lomitapide, a microsomal triglyceride transfer protein inhibitor, on the cardiovascular function in obesity. METHODS: Eight-week-old C57BL/6 mice were fed with high fat diet (HFD) for 12 weeks i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3873ac0d7f02b918b27abccfe493bafb
https://doi.org/10.1002/oby.23389
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