Investigation of the Exometabolomic Profiles of Rat Islets of Langerhans Cultured in Microfluidic Biochip

Autor: Amal Essaouiba, Rachid Jellali, Françoise Gilard, Bertrand Gakière, Teru Okitsu, Cécile Legallais, Yasuyuki Sakai, Eric Leclerc

Publikováno v: Metabolites, Vol 12, Iss 12, p 1270 (2022)

Diabetes mellitus (DM) is a complex disease with high prevalence of comorbidity and mortality. DM is predicted to reach more than 700 million people by 2045. In recent years, several advanced in vitro models and analytical tools were developed to inv

Externí odkaz: https://doaj.org/article/83958ebdd1a2410b8ed495eb0053d346

Analysis of the transcriptome and metabolome of pancreatic spheroids derived from human induced pluripotent stem cells and matured in an organ-on-a-chip

Autor: Amal Essaouiba, Rachid Jellali, Stéphane Poulain, Fumiya Tokito, Françoise Gilard, Bertrand Gakière, Soo Hyeon Kim, Cécile Legallais, Yasuyuki Sakai, Eric Leclerc

Publikováno v: Molecular Omics
Molecular Omics, 2022, 18 (8), pp.791-804. ⟨10.1039/d2mo00132b⟩

International audience; Functional differentiation of pancreatic like tissue from human induced pluripotent stem cells is one of the emerging strategies to achieve an in vitro pancreas model. Here, we propose a protocol to cultivate hiPSC-derived β-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bcec6d58fdd8a4ec29a7c5ba9bfd428
https://hal.utc.fr/hal-03861419/file/Momics-2022.pdf

Development of a pancreas-liver organ-on-chip coculture model for organ-to-organ interaction studies

Autor: Rie Kinoshita, Amal Essaouiba, Teru Okitsu, Cécile Legallais, Rachid Jellali, Marie Shinohara, Eric Leclerc, Yasuyuki Sakai, Mathieu Danoy

Publikováno v: Biochemical Engineering Journal
Biochemical Engineering Journal, Elsevier, 2020, 164, pp.107783. ⟨10.1016/j.bej.2020.107783⟩

International audience; Advances in organ-on-chip technology allowed the recapitulation of two or more organs interaction thanks to dedicated microbioreactors interconnected by microfluidic network. Here, we developed pancreas-liver coculture model i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca3dd545ade7286e2e1f4d9d8befafb
https://hal.archives-ouvertes.fr/hal-03095499/document

Membrane bioreactors for bio-artificial pancreas

Autor: Amal Essaouiba, Rachid Jellali, Cécile Legallais, Eric Leclerc

Publikováno v: Current Trends and Future Developments on (Bio-) Membranes
Current Trends and Future Developments on (Bio-) Membranes, Elsevier, pp.77-108, 2020, ⟨10.1016/B978-0-12-814225-7.00004-8⟩

Designing an efficient and functional bioartificial pancreas (BAP) at human scale to treat type I diabetes remains the Holy Grail in the 2010s although investigations started in the 1970s. Biomimetic approaches need to be performed and evaluated to o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::678f4ce4bea00d92811fde7a9e419138
https://doi.org/10.1016/b978-0-12-814225-7.00004-8