Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Amado Carreras-Sureda"'
Autor:
Amado Carreras-Sureda, Xin Zhang, Loann Laubry, Jessica Brunetti, Stéphane Koenig, Xiaoxia Wang, Cyril Castelbou, Claudio Hetz, Yong Liu, Maud Frieden, Nicolas Demaurex
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113540- (2023)
Summary: Store-operated Ca2+ entry (SOCE) mediated by stromal interacting molecule (STIM)-gated ORAI channels at endoplasmic reticulum (ER) and plasma membrane (PM) contact sites maintains adequate levels of Ca2+ within the ER lumen during Ca2+ signa
Externí odkaz:
https://doaj.org/article/77b99e83530e45649923a4aecc64dab4
Publikováno v:
Contact, Vol 6 (2023)
In this news and views, we discuss our recent publication where we described how ER-PM membrane contact sites (MCS) are modulated during store operated calcium entry (SOCE). We also examine why enforcing ER-PM MCS by tethering proteins does not not e
Externí odkaz:
https://doaj.org/article/1497cf777757484184e4abc422b969fa
Autor:
Estefanie Dufey, José Manuel Bravo-San Pedro, Cristian Eggers, Matías González-Quiroz, Hery Urra, Alfredo I. Sagredo, Denisse Sepulveda, Philippe Pihán, Amado Carreras-Sureda, Younis Hazari, Eduardo A. Sagredo, Daniela Gutierrez, Cristian Valls, Alexandra Papaioannou, Diego Acosta-Alvear, Gisela Campos, Pedro M. Domingos, Rémy Pedeux, Eric Chevet, Alejandra Alvarez, Patricio Godoy, Peter Walter, Alvaro Glavic, Guido Kroemer, Claudio Hetz
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
IRE1α plays a key role in the unfolded protein response (UPR) by promoting the unconventional splicing of the XBP1 and the selective cleavage of RNAs. Here the authors report that IRE1α is activated upon the DNA damage response and selectively cont
Externí odkaz:
https://doaj.org/article/41bd77e35d0d4d3fba7541fc5ffc6412
Autor:
Amado Carreras-Sureda, Laurence Abrami, Kim Ji-Hee, Wen-An Wang, Christopher Henry, Maud Frieden, Monica Didier, F Gisou van der Goot, Nicolas Demaurex
Publikováno v:
eLife, Vol 10 (2021)
Efficient immune responses require Ca2+ fluxes across ORAI1 channels during engagement of T cell receptors (TCR) at the immune synapse (IS) between T cells and antigen presenting cells. Here, we show that ZDHHC20-mediated S-acylation of the ORAI1 cha
Externí odkaz:
https://doaj.org/article/ad6d37568ea5409c901775a30f909b1b
Autor:
Amado Carreras-Sureda, Fanny Rubio-Moscardo, Alex Olvera, Jordi Argilaguet, Kerstin Kiefer, Beatriz Mothe, Andreas Meyerhans, Christian Brander, Rubén Vicente
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166414 (2016)
Single nucleotide polymorphisms (SNPs) located in the chromosome region 17q12-q21 are risk factors for asthma. Particularly, there are cis-regulatory haplotypes within this region that regulate differentially the expression levels of ORMDL3, GSDMB an
Externí odkaz:
https://doaj.org/article/399d41371a0a433d9686979f310283cd
Publikováno v:
Journal of Cell Science. 136
The coronavirus SARS-CoV-2, the agent of the deadly COVID-19 pandemic, is an enveloped virus propagating within the endocytic and secretory organelles of host mammalian cells. Enveloped viruses modify the ionic homeostasis of organelles to render the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9128bdc0964bb9247b25414b1fa634c
https://doi.org/10.1242/jcs.260685
https://doi.org/10.1242/jcs.260685
Changes in membrane phosphoinositides and local Ca2+elevations at sites of particle capture coordinate the dynamic remodeling of the actin cytoskeleton during phagocytosis. Here, we show that the phosphatidylinositol (PI) transfer proteins PITPNM1 (N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aaa1acc6f5b64efa9f3f827223de6573
https://doi.org/10.1101/2022.12.21.521447
https://doi.org/10.1101/2022.12.21.521447
Publikováno v:
Science Signaling. 15
The endoplasmic reticulum (ER) is the largest organelle of the cell and participates in multiple essential functions, including the production of secretory proteins, lipid synthesis, and calcium storage. Sustaining proteostasis requires an intimate c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d93816cb287489cd5e1ecf544ce0b53
https://doi.org/10.1126/scisignal.abm7524
https://doi.org/10.1126/scisignal.abm7524
Autor:
Ji-Hee, Kim, Amado, Carreras-Sureda, Monica, Didier, Christopher, Henry, Maud, Frieden, Nicolas, Demaurex
Publikováno v:
Cell calcium. 105
Tubular aggregate myopathy (TAM) is a progressive skeletal muscle disease associated with gain-of-function mutations in the ER Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::163ef495b6b7950a6f62672c16c2b45d
https://pubmed.ncbi.nlm.nih.gov/35792400
https://pubmed.ncbi.nlm.nih.gov/35792400
Enforced tethering elongates the cortical endoplasmic reticulum and limits store-operated Ca2+ entry
Publikováno v:
Journal of Cell Science. 135
Recruitment of STIM proteins to cortical endoplasmic reticulum (cER) domains forming membrane contact sites (MCSs) mediate the store-operated Ca2+ entry (SOCE) pathway essential for human immunity. The cER is dynamically regulated by STIM and tetheri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9bead8f5127693ae0c587c807bb9a9e
https://doi.org/10.1242/jcs.259313
https://doi.org/10.1242/jcs.259313