Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Amadeus Gladbach"'
Autor:
Mian Bi, Amadeus Gladbach, Janet van Eersel, Arne Ittner, Magdalena Przybyla, Annika van Hummel, Sook Wern Chua, Julia van der Hoven, Wei S. Lee, Julius Müller, Jasneet Parmar, Georg von Jonquieres, Holly Stefen, Ernesto Guccione, Thomas Fath, Gary D. Housley, Matthias Klugmann, Yazi D. Ke, Lars M. Ittner
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Excitotoxicity contributes to neuronal injury following stroke. Here the authors show that tau promotes excitotoxicity by a post-synaptic mechanism, involving site-specific control of ERK activation, in a mouse model of stroke.
Externí odkaz:
https://doaj.org/article/97fd15d6e4f1429dae0533cf6a3311e1
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148503 (2016)
The intraluminal filament model of middle cerebral artery occlusion (MCAO) in mice and rats has been plagued by inconsistency, owing in part to the multitude of variables requiring control. In this study we investigated the impact of several major va
Externí odkaz:
https://doaj.org/article/42afceb1adf34dfaa492eca3e9a60091
Autor:
Janet van Eersel, Yazi D Ke, Amadeus Gladbach, Mian Bi, Jürgen Götz, Jillian J Kril, Lars M Ittner
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22850 (2011)
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are characterized by intraneuronal deposition of the nuclear TAR DNA-binding protein 43 (TDP-43) caused by unknown mechanisms. Here, we studied TDP-43 in primary neurons
Externí odkaz:
https://doaj.org/article/69f49bd98aa64fb0a3674d388e05e148
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7917 (2009)
Diabetes mellitus (DM) is characterized by hyperglycemia caused by a lack of insulin, insulin resistance, or both. There is increasing evidence that insulin also plays a role in Alzheimer's disease (AD) as it is involved in the metabolism of beta-amy
Externí odkaz:
https://doaj.org/article/a638b28490324863882501eea6b88583
Autor:
Julius Muller, Magdalena Przybyla, Holly Stefen, Amadeus Gladbach, Ernesto Guccione, Gary D. Housley, Thomas Fath, Wei S. Lee, Lars M. Ittner, Annika van Hummel, Jasneet Parmar, Julia van der Hoven, Mian Bi, Arne Ittner, Matthias Klugmann, Yazi D. Ke, Janet van Eersel, Sook Wern Chua, Georg von Jonquieres
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications
Nature Communications
Neuronal excitotoxicity induced by aberrant excitation of glutamatergic receptors contributes to brain damage in stroke. Here we show that tau-deficient (tau−/−) mice are profoundly protected from excitotoxic brain damage and neurological deficit
Autor:
Amadeus Gladbach, Sarah Kruger, Yazi D. Ke, Fabien Delerue, Nikolas K. Haass, Annika van Hummel, Wei S. Lee, Mian Bi, Andre Bongers, Lars M. Ittner, Claire H. Stevens, Julia van der Hoven, Alexander Volkerling, Stefania Ippati, Glenda M. Halliday, Matthew C. Kiernan
Publikováno v:
Acta Neuropathologica. 130:661-678
The nuclear transactive response DNA-binding protein 43 (TDP-43) undergoes relocalization to the cytoplasm with formation of cytoplasmic deposits in neurons in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Pathogen
Autor:
Glenda M. Halliday, Wei-Yi Ong, Lars M. Ittner, Greg T. Sutherland, Kristie Stefanoska, Chesed Kai-Xin Chan, Janet van Eersel, Jillian J. Kril, Claire H. Stevens, Dorothee Abramowski, John R. Hodges, Matthias Staufenbiel, Amadeus Gladbach, Magdalena Przybyla
Publikováno v:
Neuropathology and Applied Neurobiology. 41:906-925
Aim Tau becomes hyperphosphorylated in Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD-tau), resulting in functional deficits of neurones, neurofibrillary tangle (NFT) formation and eventually dementia. Expression of mutant human
Autor:
Sook Wern Chua, Amadeus Gladbach, Renee Whan, Alexander Macmillan, Michael Kassiou, Mercedes Cueto, Lev Lewis, Inmaculada Vaca, Janet van Eersel, Lars M. Ittner, Alberto Cornejo, Claire H. Stevens
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
In Alzheimer’s disease, the microtubule-associated protein tau forms intracellular neurofibrillary tangles (NFTs). A critical step in the formation of NFTs is the conversion of soluble tau into insoluble filaments. Accordingly, a current therapeuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a6845d59b8d77eb582c41dc82316c5c
http://hdl.handle.net/10261/185311
http://hdl.handle.net/10261/185311
Autor:
Anne Poljak, Sook Wern Chua, Lisa S. Suh, Yazi D. Ke, Jillian J. Kril, Mian Bi, Joel P. Mackay, Alexander Volkerling, Alexander Macmillan, Lars M. Ittner, Ana P. G. Silva, Fabien Delerue, Greg T. Sutherland, Magdalena Przybyla, Arne Ittner, Annika van Hummel, Amadeus Gladbach, Stefania Ippati, Julia van der Hoven, Josefine Bertz, Claire H. Stevens
Publikováno v:
Science (New York, N.Y.). 354(6314)
Tau phosphorylation—not all bad Alzheimer's disease presents with amyloid-β (Aβ) plaques and tau tangles. The prevailing idea in the field is that Aβ induces phosphorylation of tau, which in turn mediates neuronal dysfunction. Working in Alzheim
Autor:
Ralph J. Mobbs, Lies Boelen, Amadeus Gladbach, Ashwin Unnikrishnan, Philip Hardy, William R. Walsh, Jeanette E. Villanueva, Avani Yeola, Louise E. Purton, Vashe Chandrakanthan, Yan Yu, Carl R. Walkley, Shane T. Grey, Alexander Macmillan, John E. Pimanda, Peter Zarzour, Lars M. Ittner, Robyn L. Ward, Qiao Qiao, Andrea Nuñez, Kathy Knezevic, Jair C. Kwan, Young Chan Kang, Luke B. Hesson, Jason W. H. Wong, Cintia Palu, Fabien Delerue, Rabab Nasrallah, Dominik Beck, Michael Carnell, Rema A. Oliver, Renee Whan
Current approaches in tissue engineering are geared toward generating tissue-specific stem cells. Given the complexity and heterogeneity of tissues, this approach has its limitations. An alternate approach is to induce terminally differentiated cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::121c9c15a1ce49b18156ab3905430b9a
https://europepmc.org/articles/PMC4843430/
https://europepmc.org/articles/PMC4843430/