Zobrazeno 1 - 10
of 202
pro vyhledávání: '"Amadeu, Llebaria"'
Autor:
Serena Notartomaso, Nico Antenucci, Mariacristina Mazzitelli, Xavier Rovira, Serena Boccella, Flavia Ricciardi, Francesca Liberatore, Xavier Gomez-Santacana, Tiziana Imbriglio, Milena Cannella, Charleine Zussy, Livio Luongo, Sabatino Maione, Cyril Goudet, Giuseppe Battaglia, Amadeu Llebaria, Ferdinando Nicoletti, Volker Neugebauer
Publikováno v:
eLife, Vol 13 (2024)
We used light-sensitive drugs to identify the brain region-specific role of mGlu5 metabotropic glutamate receptors in the control of pain. Optical activation of systemic JF-NP-26, a caged, normally inactive, negative allosteric modulator (NAM) of mGl
Externí odkaz:
https://doaj.org/article/7992b22d74894ac98d325b25e79626e5
Autor:
Silvia Panarello, Aleix González-Díez, Alice E. Berizzi, Fanny Malhaire, Roser Borràs-Tudurí, Xavier Rovira, Carme Serra, Laurent Prézeau, Jean-Philippe Pin, Cyril Goudet, Amadeu Llebaria, Xavier Gómez-Santacana
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110123- (2024)
Summary: Metabotropic glutamate receptors (mGlu) regulate multiple functions in the nervous systems and are involved in several neurological disorders. However, selectively targeting individual mGlu subtypes with spatiotemporal precision is still an
Externí odkaz:
https://doaj.org/article/b18db773dee3473cb3b7f29e86502ea3
Autor:
Aida Garrido-Charles, Miquel Bosch, Hyojung Lee, Xavier Rovira, Silvia Pittolo, Artur Llobet, Hovy Ho-Wai Wong, Ana Trapero, Carlo Matera, Claudio Papotto, Carme Serra, Amadeu Llebaria, Eduardo Soriano, Maria Sanchez-Vives, Christine Holt, Pau Gorostiza
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S299-S300 (2023)
Externí odkaz:
https://doaj.org/article/5523595799a04ed5b781ae8c2fcb6e9c
Autor:
Clara Mayayo-Vallverdú, Miguel López de Heredia, Esther Prat, Laura González, Meritxell Espino Guarch, Clara Vilches, Lourdes Muñoz, Miguel A. Asensi, Carmen Serra, Amadeu Llebaria, Mercedes Casado, Rafael Artuch, Gloria Garrabou, Pablo M. Garcia-Roves, Federico V. Pallardó, Virginia Nunes
Publikováno v:
Redox Biology, Vol 64, Iss , Pp 102801- (2023)
The high recurrence rate of cystine lithiasis observed in cystinuria patients highlights the need for new therapeutic options to address this chronic disease. There is growing evidence of an antioxidant defect in cystinuria, which has led to test ant
Externí odkaz:
https://doaj.org/article/af072a2d640d476fa7f993ce82b38f63
Autor:
Anna Duran-Corbera, Joan Font, Melissa Faria, Eva Prats, Marta Consegal, Juanlo Catena, Lourdes Muñoz, Demetrio Raldua, Antonio Rodriguez-Sinovas, Amadeu Llebaria, Xavier Rovira
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105128- (2022)
Summary: Adrenoceptors are G protein-coupled receptors involved in a large variety of physiological processes, also under pathological conditions. This is due in large part to their ubiquitous expression in the body exerting numerous essential functi
Externí odkaz:
https://doaj.org/article/1502a184142a439aae145443f2f562e0
Autor:
Pawel Matulewicz, Arnau Ramos-Prats, Xavier Gómez-Santacana, Amadeu Llebaria, Francesco Ferraguti
Publikováno v:
Cells, Vol 11, Iss 22, p 3555 (2022)
Metabotropic glutamate 5 receptors (mGlu5) are thought to play an important role in mediating emotional information processing. In particular, negative allosteric modulators (NAMs) of mGlu5 have received a lot of attention as potential novel treatmen
Externí odkaz:
https://doaj.org/article/3976892b863d48aeac4086ab6fb7d06a
Autor:
Amadeu Llebaria, Laia Josa-Culleré
Publikováno v:
Journal of Medicinal Chemistry. 66:1909-1927
The lack of selectivity of anticancer drugs limits current chemotherapy. Light-activatable drugs, whose activity can be precisely controlled with external light, could provide a more localized action of the drugs in the tumor, thus decreasing side ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fc2798ebe47a7990641be790882a699
https://doi.org/10.1021/acs.jmedchem.2c01713
https://doi.org/10.1021/acs.jmedchem.2c01713
Autor:
Miguel López de Heredia, Lourdes Muñoz, Ciriaco Carru, Salvatore Sotgia, Angelo Zinellu, Carmen Serra, Amadeu Llebaria, Yukio Kato, Virginia Nunes
Publikováno v:
Antioxidants, Vol 10, Iss 9, p 1424 (2021)
Cystinuria, a rare inherited aminoaciduria condition, is characterized by the hyperexcretion of cystine, ornithine, lysine, and arginine. Its main clinical manifestation is cystine stone formation in the urinary tract, being responsible for 1–2% to
Externí odkaz:
https://doaj.org/article/170fe2ded71447d6a2cda14f0959df13
The total synthesis of the natural (8E,15E,22E)-heptatriaconta-8,15,22-trien-2-one and (15E,22E)-heptatriaconta-15,22-dien-2-one is reported. Our synthesis involved a modular and convergent approach, based on the copper-catalyzed addition of Grignard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b055a852330382598b7082c94fa54b5d
http://hdl.handle.net/10261/329463
http://hdl.handle.net/10261/329463
Publikováno v:
Molecular Photoswitches. :921-944
G-protein-coupled receptors (GPCRs) are a super-family of membrane proteins and major targets for drug development. However, many GPCRs drug candidates suffer from a lack of selectivity. Photopharmacology gives the possibility of modulating GPCR acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05911a14ffe310372aeb8ed5feec2b3d
https://doi.org/10.1002/9783527827626.ch37
https://doi.org/10.1002/9783527827626.ch37