Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Amad Uddin"'
Autor:
Lidan Zeng, Yueming Zhu, Xin Cui, Junlong Chi, Amad Uddin, Zhuan Zhou, Xinxin Song, Mingji Dai, Massimo Cristofanilli, Kevin Kalinsky, Yong Wan
Publikováno v:
Advanced Science, Vol 11, Iss 40, Pp n/a-n/a (2024)
Abstract Tuning immune‐cold tumor hot has largely attracted attention to improve cancer treatment, including immunotherapy and antibody‐drug conjugates (ADCs). Utilizing multiomic analyses and experimental validation, this work identifies a pivot
Externí odkaz:
https://doaj.org/article/226b8baa18054f7db917c92399c165fc
Autor:
Iram Irfan, Amad Uddin, Ravi Jain, Aashima Gupta, Sonal Gupta, John V. Napoleon, Afzal Hussain, Mohamed F. Alajmi, Mukesh C. Joshi, Phool Hasan, Purnendu Kumar, Mohammad Abid, Shailja Singh
Publikováno v:
Heliyon, Vol 10, Iss 3, Pp e25077- (2024)
The rapid emergence of resistance to existing frontline antimalarial drugs emphasizes a need for the development of target-oriented molecules with novel modes of action. Given the importance of a plant-like Calcium-Dependent Protein Kinase 1 (PfCDPK1
Externí odkaz:
https://doaj.org/article/69166908d3804c9e91213a57d661ecb6
Autor:
Asghar Ali, Phool Hasan, Mohammad Irfan, Amad Uddin, Ashba Khan, Juhi Saraswat, Ronan Maguire, Kevin Kavanagh, Rajan Patel, Mukesh C. Joshi, Amir Azam, Mohd. Mohsin, Qazi Mohd. Rizwanul Haque, Mohammad Abid
Publikováno v:
ACS Omega, Vol 6, Iss 42, Pp 27798-27813 (2021)
Externí odkaz:
https://doaj.org/article/6d40933b677f4a29b37202c9e2371722
Autor:
Amad Uddin, Sonal Gupta, Taj Mohammad, Diksha Shahi, Afzal Hussain, Mohamed F. Alajmi, Hesham R. El-Seedi, Imtaiyaz Hassan, Shailja Singh, Mohammad Abid
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
We employed a comprehensive approach of target-based virtual high-throughput screening to find potential hits from the ZINC database of natural compounds against cysteine proteases falcipain-2 and falcipain-3 (FP2 and FP3). Molecular docking studies
Externí odkaz:
https://doaj.org/article/2ac513f3116149ef9b82599d1a902759
Autor:
Iram Irfan, Asghar Ali, Bharati Reddi, Mohd. Abrar Khan, Phool Hasan, Sarfraz Ahmed, Amad Uddin, Magdalena Piatek, Kevin Kavanagh, Qazi Mohd. Rizwanul Haque, Shailja Singh, Anthony Addlagatta, Mohammad Abid
Publikováno v:
Antibiotics, Vol 11, Iss 8, p 1126 (2022)
Methionine aminopeptidases (MetAPs) are attractive drug targets due to their essential role in eukaryotes as well as prokaryotic cells. In this study, biochemical assays were performed on newly synthesized Isatin-pyrazole hydrazones (PS1–14) to ide
Externí odkaz:
https://doaj.org/article/725514b7da654708a3701cde7e31c21b
Autor:
Kashish Azeem, Mofieed Ahmed, Taj Mohammad, Amad Uddin, Anas Shamsi, Md. Imtaiyaz Hassan, Shailja Singh, Rajan Patel, Mohammad Abid
Publikováno v:
Journal of Biomolecular Structure and Dynamics. :1-17
Hydroxychloroquine (HCQ), a quinoline based medicine is commonly used to treat malaria and autoimmune diseases such as rheumatoid arthritis. Since, human serum albumin (HSA) serves as excipient for vaccines or therapeutic protein drugs, it is importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0117944e0e4e6f2bfcc19806695a258
https://doi.org/10.1080/07391102.2022.2107077
https://doi.org/10.1080/07391102.2022.2107077
Autor:
Ashba Khan, Amad Uddin, Kevin Kavanagh, Asghar Ali, Phool Hasan, Mohammad Irfan, Ronan Maguire, Mohd. Mohsin, Juhi Saraswat, Mohammad Abid, Amir Azam, Rajan Patel, Qazi Mohd Rizwanul Haque, Mukesh C. Joshi
Publikováno v:
ACS Omega, Vol 6, Iss 42, Pp 27798-27813 (2021)
ACS Omega
ACS Omega
In this work, substituted 1,2,4-oxadiazoles (OX1− OX27) were screened against five bacterial strains, identified to be OX7 and OX11 as growth inhibitors with minimum inhibitory concentration (MIC) values of 31.25 and 15.75 μg/mL, respectively. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee6fd13cc8fe6f7603bccd66b2f056a
https://doaj.org/article/6d40933b677f4a29b37202c9e2371722
https://doaj.org/article/6d40933b677f4a29b37202c9e2371722
Autor:
Iram Irfan, Amad Uddin, Ravi Jain, Aashima Gupta, Sonal Gupta, John V. Napoleon, Afzal Hussain, Mohamed F. Alajmi, Mukesh C. Joshi, Phool Hasan, Mohammad Abid, Shailja Singh
To combat the emergence of drug resistance against the existing antimalarials, novel side chain containing 7-chloroquinoline-indole-chalcones tethered with a triazole (CQTrICh-analogs 7 (a-s) and 9) were designed and synthesized by reacting substitut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cffe11264e5e732d377e1a6c174b04c
https://doi.org/10.1101/2022.07.07.498981
https://doi.org/10.1101/2022.07.07.498981
Publikováno v:
ChemistrySelect. 6:2323-2334
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65f1e0c487e462e94dab49e8db5c900a
https://doi.org/10.1002/slct.202004781
https://doi.org/10.1002/slct.202004781
Autor:
Vigyasa Singh, Amad Uddin, Mohammad Abid, Kailash C. Pandey, Shailja Singh, Rahul S. Hada, Babita Aneja
Publikováno v:
Current Topics in Medicinal Chemistry. 20:377-389
Background: Novel drug development against malaria parasite over old conventional antimalarial drugs is essential due to rapid and indiscriminate use of drugs, which led to the emergence of resistant strains. Methods: In this study, previously report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55f951b9f037889a05525a3c5473fd99
https://doi.org/10.2174/1568026620666200130162347
https://doi.org/10.2174/1568026620666200130162347