Výsledky vyhledávání - "Amélie Velghe"

Akademický článek

PDGF-D expression is down-regulated by TGFβ in fibroblasts.

Autor: Saima Charni Chaabane, Alexandra Coomans de Brachène, Ahmed Essaghir, Amélie Velghe, Sandra Lo Re, Julie Stockis, Sophie Lucas, Levon M Khachigian, François Huaux, Jean-Baptiste Demoulin

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e108656 (2014)

Transforming growth factor-β (TGFβ) is a key mediator of fibrogenesis. TGFβ is overexpressed and activated in fibrotic diseases, regulates fibroblast differentiation into myofibroblasts and induces extracellular matrix deposition. Platelet-derived

Externí odkaz: https://doaj.org/article/3a2ad50f21604605b26788215a2f671a

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Germline

Publikováno v: Journal of medical genetics. 54(9)

Sarcomas are rare mesenchymal malignancies whose pathogenesis is poorly understood; both environmental and genetic risk factors could contribute to their aetiology.We performed whole-exome sequencing (WES) in a familial aggregation of three individua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::067318fbc9bc6e7b93bdd22848c8a71a
https://pubmed.ncbi.nlm.nih.gov/28592523

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PDGFRB mutants found in patients with familial infantile myofibromatosis or overgrowth syndrome are oncogenic and sensitive to imatinib

Autor: Stefan N. Constantinescu, Bengt Hallberg, Florence A. Arts, Christian Pecquet, Jean-Baptiste Demoulin, Amélie Velghe, D Chand

Publikováno v: Oncogene. 35(25)

Recently, germline and somatic heterozygous mutations in the platelet-derived growth factor receptor β (PDGFRB) have been associated with familial infantile myofibromatosis (IM), which is characterized by soft tissue tumors, and overgrowth syndrome,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e22ba0cb6dcc68f155871257a9bd8b0
https://pubmed.ncbi.nlm.nih.gov/26455322

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PDGF-D expression is down-regulated by TGFβ in fibroblasts

Autor: Levon Lm Khachigian, Ahmed Essaghir, Sophie Lucas, Sandra Lo Re, Jean-Baptiste Demoulin, Julie Stockis, François Huaux, Saima S Charni Chaabane, Alexandra Coomans De Brachene, Amélie Velghe

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e108656 (2014)
PLoS ONE
PLoS One, Vol. 9, no. 10, p. e108656 (2014)
PloS one, 9 (10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d3dfc1ab492ccbeb3ec1800a92afaa1
http://europepmc.org/articles/PMC4184810?pdf=render

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PDGFRA alterations in cancer: characterization of a gain-of-function V536E transmembrane mutant as well as loss-of-function and passenger mutations

Autor: S Charni, D Chand, Amélie Velghe, Ahmed Essaghir, Carmen P. Montano-Almendras, Bengt Hallberg, Anton A. Polyansky, Jean-Baptiste Demoulin, S Van Cauwenberghe

Publikováno v: Oncogene. 33(20)

Activating mutations in the platelet-derived growth factor (PDGF) receptor alpha (PDGFRA) have been described in patients with gastrointestinal stromal tumors or myeloid malignancies associated with hypereosinophilia. These patients respond well to i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f16dbf230c2c208db6d3383a81b0688
https://pubmed.ncbi.nlm.nih.gov/23752188

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[Role of PDGF and FGF receptors in cancer]

Autor: J B, Demoulin, Sandrine, Medves, Federica, Toffalini, Ahmed, Essaghir, Anders, Kallin, Carmen, Montano, Amélie, Velghe, François, Duhoux

Publikováno v: Bulletin et memoires de l'Academie royale de medecine de Belgique. 165(5-6)

Growth factors of the PDGF and FGF families act through receptor tyrosine kinases. These receptors can be activated by chromosomal rearrangements in myeloid neoplasms associated with hypereosinophilia. We identified a new fusion gene between KANK1 an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::333d40ea3615e3a0a823f81b23cf62be
https://pubmed.ncbi.nlm.nih.gov/21513119

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The mouse Muc5b mucin gene is transcriptionally regulated by thyroid transcription factor-1 (TTF-1) and GATA-6 transcription factors.: Regulation of Muc5b mucin gene by TTF-1 and GATA factors

Autor: Marie-Paule Ducourouble, Marie-Christine Copin, Isabelle Van Seuningen, Amélie Velghe, Ingrid B. Renes, Nicolas Jonckheere

Publikováno v: FEBS Journal
FEBS Journal, Wiley, 2011, 278 (2), pp.282-94. ⟨10.1111/j.1742-4658.2010.07945.x⟩
FEBS Journal, 2011, 278 (2), pp.282-94. ⟨10.1111/j.1742-4658.2010.07945.x⟩

International audience; MUC5B is one of the major mucin genes expressed in the respiratory tract. Previous studies in our laboratory have demonstrated that MUC5B is expressed in human lung adenocarcinomas and during lung morphogenesis. Moreover, in h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3233ba83b8b1610a7efe4a3f6c0bd447
https://www.hal.inserm.fr/inserm-00807850/file/FEBS_J_-acceptA_.pdf

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The mouse Muc5b mucin gene is transcriptionally regulated by thyroid transcription factor-1 (TTF-1) and GATA-6 transcription factors

Autor: Nicolas, Jonckheere, Amélie, Velghe, Marie-Paule, Ducourouble, Marie-Christine, Copin, Ingrid B, Renes, Isabelle, Van Seuningen

Publikováno v: The FEBS journal. 278(2)

MUC5B is one of the major mucin genes expressed in the respiratory tract. Previous studies in our laboratory have demonstrated that MUC5B is expressed in human lung adenocarcinomas and during lung morphogenesis. Moreover, in human lung adenocarcinoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aa375d1b33a69f133301b34c25f875ac
https://pubmed.ncbi.nlm.nih.gov/21126317

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Transcriptional activation of the murine Muc5ac mucin gene in epithelial cancer cells by TGF-β/Smad4 signalling pathway is potentiated by Sp1

Autor: Alexandra W. C. Einerhand, Nicolas Jonckheere, Amélie Velghe, Marjolein Sutmuller, Marie-Pierre Buisine, Marie-Paule Ducourouble, Hans A. Büller, Pascal Pigny, Maria van der Sluis, Jean-Pierre Aubert, Isabelle Van Seuningen

Publikováno v: Biochemical Journal
Biochemical Journal, Portland Press, 2004, 377, pp.797-808
HAL
Biochemical Journal, 2004, 377, pp.797-808. ⟨10.1042/BJ20030948⟩
Biochemical Journal, Portland Press, 2004, 377, pp.797-808. ⟨10.1042/BJ20030948⟩
Biochemical Journal, 2004, 377, pp.797-808

The nucleotide sequence of the pMS1 clone was submitted to the GenBank Nucleotide Sequence Database under accession number {"type":"entrez-nucleotide","attrs":{"text":"AF288076","term_id":"33339735","term_text":"AF288076"}}AF288076. Changes in the ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9a46cda5180f4940140bea5e754a20d
https://hal.archives-ouvertes.fr/hal-02905715/file/BJ20030948.pdf

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