Enhanced Chondrogenic Differentiation Activities in Human Bone Marrow Aspirates via sox9 Overexpression Mediated by pNaSS-Grafted PCL Film-Guided rAAV Gene Transfer

Autor: Jagadeesh K. Venkatesan, Weikun Meng, Ana Rey-Rico, Gertrud Schmitt, Susanne Speicher-Mentges, Céline Falentin-Daudré, Amélie Leroux, Henning Madry, Véronique Migonney, Magali Cucchiarini

Publikováno v: Pharmaceutics, Vol 12, Iss 3, p 280 (2020)

Background: The delivery of therapeutic genes in sites of articular cartilage lesions using non-invasive, scaffold-guided gene therapy procedures is a promising approach to stimulate cartilage repair while protecting the cargos from detrimental immun

Externí odkaz: https://doaj.org/article/ba2b701ca7614da384637281e02ad022

rAAV TGF-β and FGF-2 Overexpression via pNaSS-Grafted PCL Films Stimulates the Reparative Activities of Human ACL Fibroblasts

Autor: Cucchiarini, Mahnaz Amini, Jagadeesh K. Venkatesan, Tuan N. Nguyen, Wei Liu, Amélie Leroux, Henning Madry, Véronique Migonney, Magali

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 11140

Lesions in the human anterior cruciate ligament (ACL) are frequent, unsolved clinical issues due to the limited self-healing ability of the ACL and lack of treatments supporting full, durable ACL repair. Gene therapy guided through the use of biomate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::b55772f0402018beea4bc718b21c5a79

Feasibility Study of the Elaboration of a Biodegradable and Bioactive Ligament Made of Poly(ε-caprolactone)-pNaSS Grafted Fibers for the Reconstruction of Anterior Cruciate Ligament: In Vivo Experiment

Autor: Amélie Leroux, Véronique Migonney, E. Maurice, V. Viateau

Publikováno v: Innovation and Research in BioMedical engineering
Innovation and Research in BioMedical engineering, Elsevier Masson, 2019, 40 (1), pp.38-44. ⟨10.1016/j.irbm.2018.10.011⟩
Innovation and Research in BioMedical engineering, 2019, 40 (1), pp.38-44. ⟨10.1016/j.irbm.2018.10.011⟩

Background The anterior cruciate ligament rupture is a common injury which mainly affects young and active population. Faced to this problem, the development of synthetic structures for ligament reconstruction is increasing. The most recent researche

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e70715944ee6bb56701d8ce19806df53
https://doi.org/10.1016/j.irbm.2018.10.011

The effect of pNaSS grafting of knitted poly(ε-caprolactone) artificial ligaments on in vitro mineralization and in vivo osseointegration

Autor: Emeline Maurice, André Luiz Reis Rangel, Jagadeesh K Venkatesan, Amélie Leroux, Hanane El Hafci, Diane Pichard, Mathieu Manassero, Thibault Godineau, Julie Vial, Gertrud Schmitt, Susanne Speicher-Mentges, Marie Vandesteene, Magali Cucchiarini, Véronique Migonney, Véronique Viateau

Publikováno v: Materialia. 21:101331

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39eb6b2ece47329a5c4e5cb8e17d2b55
https://doi.org/10.1016/j.mtla.2022.101331

Genetically modified human bone marrow aspirates by rAAV mediated overexpression of sox9 and TGF-beta viapnass-grafted poly(e-caprolactone) film-guided delivery activates the chondrogenic activity upon implantation in human osteochondral defects

Autor: Véronique Migonney, Céline Falentin-Daudré, J.K. Venkatesan, Magali Cucchiarini, Amélie Leroux, C. Marmillon

Publikováno v: Osteoarthritis and Cartilage. 29:S194-S195

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64e5e4442e407ff7f22c3cfae772b6dd
https://doi.org/10.1016/j.joca.2021.02.262