Human HOX Proteins Use Diverse and Context-Dependent Motifs to Interact with TALE Class Cofactors

Autor: Amélie Dard, Jonathan Reboulet, Yunlong Jia, Françoise Bleicher, Marilyne Duffraisse, Jean-Marc Vanaker, Christelle Forcet, Samir Merabet

Publikováno v: Cell Reports, Vol 22, Iss 11, Pp 3058-3071 (2018)

Summary: HOX proteins achieve numerous functions by interacting with the TALE class PBX and MEIS cofactors. In contrast to this established partnership in development and disease, how HOX proteins could interact with PBX and MEIS remains unclear. Her

Externí odkaz: https://doaj.org/article/5c2fdd5650144ac7a76465c946856c01

Molecular insights into the origin of the Hox-TALE patterning system

Autor: Bruno Hudry, Morgane Thomas-Chollier, Yael Volovik, Marilyne Duffraisse, Amélie Dard, Dale Frank, Ulrich Technau, Samir Merabet

Publikováno v: eLife, Vol 3 (2014)

Despite tremendous body form diversity in nature, bilaterian animals share common sets of developmental genes that display conserved expression patterns in the embryo. Among them are the Hox genes, which define different identities along the anterior

Externí odkaz: https://doaj.org/article/1e02995c6eee45dea1cd3479b5e5f3ea

Inhibitory activities of short linear motifs underlie Hox interactome specificity in vivo

Autor: Samir Merabet, Marilyne Duffraisse, Bruno Hudry, Séverine Viala, Manon Baëza, Ana Rogulja-Ortmann, Amélie Dard, Marjorie Heim, Christine Brun

Publikováno v: eLife, Vol 4 (2015)
eLife
eLife, eLife Sciences Publication, 2015, 4 (UNSP e06034), ⟨10.7554/eLife.06034⟩
eLife, 2015, 4 (UNSP e06034), ⟨10.7554/eLife.06034⟩
eLife, eLife Sciences Publication, 2015, 4, ⟨10.7554/eLife.06034⟩

Hox proteins are well-established developmental regulators that coordinate cell fate and morphogenesis throughout embryogenesis. In contrast, our knowledge of their specific molecular modes of action is limited to the interaction with few cofactors.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f3844d6bc57b979d6be19c3f5af2f25
https://elifesciences.org/articles/06034

Molecular insights into the origin of the Hox-TALE patterning system

Autor: Amélie Dard, Marilyne Duffraisse, Ulrich Technau, Morgane Thomas-Chollier, Dale Frank, Bruno Hudry, Yael Volovik, Samir Merabet

Publikováno v: eLife
eLife, eLife Sciences Publication, 2014, 3, ⟨10.7554/eLife.01939⟩
eLife, 2014, 3, ⟨10.7554/elife.01939⟩
eLife, Vol 3 (2014)
eLife, eLife Sciences Publication, 2014, 3, ⟨10.7554/elife.01939⟩

Despite tremendous body form diversity in nature, bilaterian animals share common sets of developmental genes that display conserved expression patterns in the embryo. Among them are the Hox genes, which define different identities along the anterior

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a533c401916dbb4a62f102d922055ab
https://hal.archives-ouvertes.fr/hal-03437665