Výsledky vyhledávání - "Amélie Cumont"

Akademický článek

Get to Know Your Neighbors: Characterization of Close Bacillus anthracis Isolates and Toxin Profile Diversity in the Bacillus cereus Group

Autor: Mehdi Abdelli, Charlotte Falaise, Valérie Morineaux-Hilaire, Amélie Cumont, Laurent Taysse, Françoise Raynaud, Vincent Ramisse

Publikováno v: Microorganisms, Vol 11, Iss 11, p 2721 (2023)

Unexpected atypical isolates of Bacillus cereus s.l. occasionally challenge conventional microbiology and even the most advanced techniques for anthrax detection. For anticipating and gaining trust, 65 isolates of Bacillus cereus s.l. of diverse orig

Externí odkaz: https://doaj.org/article/4f8f32149f124cdab48a23b2bbe3622b

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Serum and Pulmonary Uric Acid in Pulmonary Arterial Hypertension

Publikováno v: European Respiratory Journal
European Respiratory Journal, European Respiratory Society, 2021, 58 (2), pp.2000332. ⟨10.1183/13993003.00332-2020⟩
European Respiratory Journal, 2021, 58 (2), pp.2000332. ⟨10.1183/13993003.00332-2020⟩

Previous studies have suggested an association between uric acid (UA) and the severity of pulmonary arterial hypertension (PAH), but it is unknown whether UA contributes to disease pathogenesis.The aim of this study was to determine the prognostic va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4124d5021b0a2a1f280549593010fe8
https://www.hal.inserm.fr/inserm-03118201

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Loss of Bmp9 does not lead to spontaneous pulmonary hypertension, but attenuates vascular remodeling in experimental models

Autor: Nihel Berrebeh, Marc Humbert, Sabine Bailly, Christophe Guignabert, Raphaël Thuillet, Ly Tu, Alice Huertas, Benjamin Le Vely, Amélie Cumont, Ignacio Anegon

Publikováno v: Pulmonary hypertension.

Introduction: Despite increasing evidence suggesting that the Bone Morphogenetic Protein (BMP)-9 signaling pathway is playing a role in the pulmonary hypertension (PH) pathogenesis, the data in the literature are still controversial. Aims and Objecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::20dba38bb4a3865d92638d0128611d9a
https://doi.org/10.1183/13993003.congress-2020.3558

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Additive Protective Effects of Sacubitril/Valsartan and Bosentan on Vascular Remodeling in Experimental Pulmonary Hypertension

Autor: Ly Tu, Amélie Cumont, Raphaël Thuillet, Laurent Savale, Alice Huertas, Mohamed Reda Amar Djessas, Marc Humbert, Guillaume Hebert, Christophe Guignabert, Marie-Camille Chaumais, Pauline Gaignard

Publikováno v: Cardiovascular Research
Cardiovascular Research, Oxford University Press (OUP), 2020, pp.cvaa200. ⟨10.1093/cvr/cvaa200⟩

Aims Although right ventricular (RV) function is an important determinant of morbidity and mortality in patients with pulmonary arterial hypertension (PAH), there is no treatment targeting directly the RV. We evaluate the efficacy of sacubitril/valsa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b3c0a74b98793b4f15307bc27c8c52
https://www.hal.inserm.fr/inserm-02907132

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Lineage Tracing Reveals the Dynamic Contribution of Pericytes to the Blood Vessel Remodeling in Pulmonary Hypertension

Autor: Raphaël Thuillet, Alice Huertas, Amélie Cumont, Christophe Guignabert, Jennifer Bordenave, Nihel Berrebeh, Ly Tu, Elie Fadel, Marc Humbert, Benjamin Le Vely, Sophie Nadaud, Laurent Savale

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology
Arteriosclerosis, Thrombosis, and Vascular Biology, 2020, 40 (3), pp.766-782. ⟨10.1161/ATVBAHA.119.313715⟩
Arteriosclerosis, Thrombosis, and Vascular Biology, American Heart Association, 2020, Ahead of print. ⟨10.1161/ATVBAHA.119.313715⟩
Arteriosclerosis, Thrombosis, and Vascular Biology, American Heart Association, 2020, 40 (3), pp.766-782. ⟨10.1161/ATVBAHA.119.313715⟩

Objective: Excessive accumulation of resident cells within the pulmonary vascular wall represents the hallmark feature of the remodeling occurring in pulmonary arterial hypertension (PAH). Furthermore, we have previously demonstrated that pulmonary a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::643bbeec05347f0d050bd2efb680a7fb
https://www.hal.inserm.fr/inserm-02454982v2

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Therapeutic effect of pirfenidone in the sugen/hypoxia rat model of severe pulmonary hypertension

Autor: Raphaël Thuillet, Paul-Benoit Poble, Maria-Rosa Ghigna, Ly Tu, Laurent Savale, Alice Huertas, Marc Humbert, Peter Dorfmüller, Timothée Quatremare, Carole Phan, Christophe Guignabert, Jennifer Bordenave, Amélie Cumont

Publikováno v: FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2018, 33 (3), pp.3670-3679. ⟨10.1096/fj.201801659R⟩
FASEB Journal, 2018, 33 (3), pp.3670-3679. ⟨10.1096/fj.201801659R⟩

International audience; Heightened pulmonary artery smooth muscle cell (PA-SMC) proliferation and migration and dynamic remodeling of the extracellular matrix are hallmark pathogenic features of pulmonary arterial hypertension (PAH). Pirfenidone (PFD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff22268dc4a46cbb42f4a91934c21afd
https://doi.org/10.1096/fj.201801659r

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Neutralization of CXCL12 attenuates established pulmonary hypertension in rats

Autor: Amélie Cumont, Jean-Luc Galzi, Christophe Guignabert, Laurent Savale, Raphaël Thuillet, Claire Marsol, Ly Tu, Dominique Bonnet, Marcel Hibert, Jennifer Bordenave, Carole Phan, Marc Humbert, Nelly Frossard, Alice Huertas

Publikováno v: Cardiovascular Research
Cardiovascular Research, Oxford University Press (OUP), 2019, ⟨10.1093/cvr/cvz153⟩

Aims The progressive accumulation of cells in pulmonary vascular walls is a key pathological feature of pulmonary arterial hypertension (PAH) that results in narrowing of the vessel lumen, but treatments targeting this mechanism are lacking. The C-X-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0838b5f91cf6123daeb063459ffda912
https://hal.archives-ouvertes.fr/hal-02366304/document

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Selective BMP-9 Inhibition Partially Protects Against Experimental Pulmonary Hypertension

Autor: Raphaël Thuillet, Alice Huertas, Carole Phan, Ayumi Sekine, Christine Mallet, Ly Tu, Sabine Bailly, Christophe Guignabert, Laurent Savale, Olli Ritvos, Florian Robert, Jennifer Bordenave, Laurent Guyon, Agnès Desroches-Castan, Marc Humbert, Jean-Jacques Feige, Amélie Cumont

Publikováno v: Circulation Research
Circulation Research, American Heart Association, 2019, 124 (6), pp.846-855. ⟨10.1161/CIRCRESAHA.118.313356⟩
HAL
Circulation Research, American Heart Association, 2019
Circulation Research, 2019, 124 (6), pp.846-855. ⟨10.1161/CIRCRESAHA.118.313356⟩
Circulation Research, 2019

Rationale: Although many familial cases of pulmonary arterial hypertension exhibit an autosomal dominant mode of inheritance with the majority having mutations in essential constituents of the BMP (bone morphogenetic protein) signaling, the specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5789222560e2a2270f911fd3b3f1fe5e
https://www.hal.inserm.fr/inserm-02581297/document

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