Pharmacomodulations around an anti-Alzheimer drug-candidate

Autor: Sylvain Marc, Christophe Mésangeau, Mathilde Coevoet, Amélie Barczyk, Stéphane Burlet, Philippe Verwaerde, Cecilia Estrella, Cyrille Brantis, Nicolas Sergeant, Pascal Carato, Patricia Melnyk

Publikováno v: European Journal of Medicinal Chemistry Reports, Vol 4, Iss , Pp 100020- (2022)

Alzheimer's disease is a complex and multifactorial disease characterized by extracellular Aβ peptide deposits related to the deregulation of APP metabolism, intracellular aggregation of hyper and abnormally phosphorylated isoforms of Tau proteins,

Externí odkaz: https://doaj.org/article/d04e48aff8dd43daab307fe1dceece4c

High ligand efficiency quinazoline compounds as novel A

Autor: Raphaël, Bolteau, Romain, Duroux, Amélie, Laversin, Brandon, Vreulz, Anna, Shiriaeva, Benjamin, Stauch, Gye Won, Han, Vadim, Cherezov, Nicolas, Renault, Amélie, Barczyk, Séverine, Ravez, Mathilde, Coevoet, Patricia, Melnyk, Maxime, Liberelle, Saïd, Yous

Publikováno v: European journal of medicinal chemistry. 241

The past fifty years have been marked by the surge of neurodegenerative diseases. Unfortunately, current treatments are only symptomatic. Hence, the search for new and innovative therapeutic targets for curative treatments becomes a major challenge.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9dbcd2e0b44d5188113542cf70cf8484
https://pubmed.ncbi.nlm.nih.gov/35933788

New phenylaniline derivatives as modulators of amyloid protein precursor metabolism

Autor: Marion Gay, Pascal Carato, Mathilde Coevoet, Nicolas Renault, Paul-Emmanuel Larchanché, Amélie Barczyk, Saïd Yous, Luc Buée, Nicolas Sergeant, Patricia Melnyk

Publikováno v: Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, 2018, 26 (8), pp.2151-2164. ⟨10.1016/j.bmc.2018.03.016⟩
Bioorganic and Medicinal Chemistry, Elsevier, 2018, 26 (8), pp.2151-2164. ⟨10.1016/j.bmc.2018.03.016⟩

The chloroquinoline scaffold is characteristic of anti-malarial drugs such as chloroquine (CQ) or amodiaquine (AQ). These drugs are also described for their potential effectiveness against prion disease, HCV, EBV, Ebola virus, cancer, Parkinson or Al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99e89dc90e3baafdaabb4fb0f4714989
https://doi.org/10.1016/j.bmc.2018.03.016

Benzo[d]thiazol-2(3H)-ones as new potent selective CB2 agonists with anti-inflammatory properties

Autor: Amélie Barczyk, Madjid Djouina, Nicolas Renault, Davy Baudelet, Valéria Moas Heloire, Pascal Carato, Régis Millet, Diana Escalante Rocha, Natascha Leleu-Chavain, Mathilde Body-Malapel

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2019, 165, pp.347-362. ⟨10.1016/j.ejmech.2018.12.008⟩
European Journal of Medicinal Chemistry, 2019, 165, pp.347-362. ⟨10.1016/j.ejmech.2018.12.008⟩

International audience; The high distribution of CB receptors in immune cells suggests their important role in the control of inflammation. Growing evidence offers this receptor as an attractive therapeutic target: selective CB agonists are able to m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa7bdfd8db615a5af2213f4367873a8
https://hal.univ-lille.fr/hal-02149143/file/S0223523418310456.pdf

Benzo[d]thiazol-2(3H)-ones as new potent selective CB

Autor: Natascha, Leleu-Chavain, Davy, Baudelet, Valéria Moas, Heloire, Diana Escalante, Rocha, Nicolas, Renault, Amélie, Barczyk, Madjid, Djouina, Mathilde, Body-Malapel, Pascal, Carato, Régis, Millet

Publikováno v: European journal of medicinal chemistry. 165

The high distribution of CB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3e3b0fad06e9d44435f4eef48b9b448e
https://pubmed.ncbi.nlm.nih.gov/30583970