An examination of the efficacy and safety of fenfluramine in adults, children, and adolescents with Dravet syndrome in a real‐world practice setting: A report from the Fenfluramine European Early Access Program

Autor: Renzo Guerrini, Nicola Specchio, Ángel Aledo‐Serrano, Milka Pringsheim, Francesca Darra, Thomas Mayer, Antonio Gil‐Nagel, Tilman Polster, Sameer M. Zuberi, Amélie Lothe, Arnold Gammaitoni, Adam Strzelczyk

Publikováno v: Epilepsia Open, Vol 7, Iss 4, Pp 578-587 (2022)

Abstract Objective To examine the efficacy and safety of fenfluramine in patients with Dravet syndrome (DS) in three age groups:

Externí odkaz: https://doaj.org/article/b5e7d1e7768f4ec49153337296d89035

Impact of Fenfluramine on Drop Seizure Frequency in Adults or Dose-Capped Patients With Lennox-Gastaut Syndrome: Comparative Analysis of Clinical Trial Data (S44.002)

Autor: Kelly G. Knupp, Ingrid E. Scheffer, Berten Ceulemans, Joseph Sullivan, Katherine C. Nickels, Lieven Lagae, Renzo Guerrini, Sameer M. Zuberi, Rima Nabbout, Kate Riney, Shikha Polega, Amélie Lothe, Ronald Davis, Antonio Gil-Nagel

Publikováno v: Thursday, April 27.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::761f0ed53bb2d408166e5fb1b198d9ee
https://doi.org/10.1212/wnl.0000000000202351

EEG parameters as endpoints in epilepsy clinical trials - An expert panel opinion paper

Autor: Jeffrey, Buchhalter, Caroline, Neuray, Jocelyn Y, Cheng, O'Neill, D'Cruz, Alexandre N, Datta, Dennis, Dlugos, Jacqueline, French, Dietrich, Haubenberger, Joseph, Hulihan, Pavel, Klein, Robert W, Komorowski, Lynn, Kramer, Amélie, Lothe, Rima, Nabbout, Emilio, Perucca, Peter Van, der Ark

Publikováno v: Epilepsy Research. 187:107028

The lack of ideal measurement of treatment efficacy is a well acknowledged problem in the epilepsy community, both in clinical care and clinical trials. Whilst still the current gold-standard, self-reported seizure frequency significantly underestima

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ef57b1fe4441aef87096383913beac6
https://doi.org/10.1016/j.eplepsyres.2022.107028

Candidate Socioemotional Remediation Program for Individuals with Intellectual Disability

Autor: Mélanie Chabloz, Catherine Pasca, Stephan Eliez, Jérôme Redouté, Bronwyn Glaser, Daniel Dukes, Amélie Lothe

Publikováno v: American journal on intellectual and developmental disabilities
American Journal on Intellectual and Developmental Disabilities, Vol. 117, No 5 (2012) pp. 368-83

The authors developed a computerized program, Vis-à-Vis (VAV), to improve socioemotional functioning and working memory in children with developmental disabilities. The authors subsequently tested whether participants showed signs of improving the t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b4ed200a4ce7a99f2566688636113f
https://doi.org/10.1352/1944-7558-117.5.368

Association between triallelic polymorphism of the serotonin transporter and [18F]MPPF binding potential at 5-HT1A receptors in healthy subjects

Autor: Nicolas Costes, Philippe Ryvlin, Amélie Lothe, Sandrine Bouvard, Philip Gorwood, Didier Le Bars, Claudette Boni, Franck Lavenne

Publikováno v: NeuroImage. 47:482-492

Previous [(11)C]WAY100-635 PET studies have demonstrated that the short (S) and long (L) alleles of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) were associated with distinct patterns of 5-HT(1A) receptor distribution in human.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7c070acab32f820219e3097bc94922d
https://doi.org/10.1016/j.neuroimage.2009.04.067