Zobrazeno 1 - 10
of 200
pro vyhledávání: '"Amélia P. Rauter"'
Autor:
Ana M. de Matos, Patrícia Calado, Mónica Miranda, Rita Almeida, Amélia P. Rauter, M. Conceição Oliveira, Vera Manageiro, Manuela Caniça
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract The escalating antimicrobial resistance crisis urges the development of new antibacterial treatments with innovative mechanisms of action, particularly against the critical priority carbapenem-resistant Acinetobacter baumannii (CRAB), Pseudo
Externí odkaz:
https://doaj.org/article/1aaa138ea3104bb9beb2f92c1d89044a
Publikováno v:
Pharmaceuticals, Vol 17, Iss 6, p 718 (2024)
Antimicrobial resistance (AMR) is an increasingly concerning phenomenon that requires urgent attention because it poses a threat to human and animal health. Bacteria undergo continuous evolution, acquiring novel resistance mechanisms in addition to t
Externí odkaz:
https://doaj.org/article/9ca2e6c3ca8d44719378c99ddc63772f
Publikováno v:
Applied Sciences, Vol 13, Iss 8, p 4651 (2023)
The increase in the occurrence of the multifactorial Alzheimer’s disease (AD) demands an urgent effort towards the development of effective anti-AD agents, such as the multitarget-directed ligands (MTDLs). In fact, AD is a genetic and an environmen
Externí odkaz:
https://doaj.org/article/450c05c992324edb8f3077d0bc0dce0b
Autor:
Ana Marta de Matos, Maria Teresa Blázquez-Sánchez, Carla Sousa, Maria Conceição Oliveira, Rodrigo F. M. de Almeida, Amélia P. Rauter
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract The concept of Pan-Assay Interference Compounds (PAINS) is regarded as a threat to the recognition of the broad bioactivity of natural products. Based on the established relationship between altered membrane dipole potential and transmembran
Externí odkaz:
https://doaj.org/article/14eb2adecb684795a97f8a351e9ceaca
Autor:
Ignazio Schino, Mariangela Cantore, Modesto de Candia, Cosimo D. Altomare, Catarina Maria, João Barros, Vasco Cachatra, Patrícia Calado, Karina Shimizu, Adilson A. Freitas, Maria C. Oliveira, Maria J. Ferreira, José N. C. Lopes, Nicola A. Colabufo, Amélia P. Rauter
Publikováno v:
Pharmaceuticals, Vol 16, Iss 1, p 54 (2022)
Alzheimer’s Disease (AD) is characterized by a progressive cholinergic neurotransmission imbalance, with a decrease of acetylcholinesterase (AChE) activity followed by a significant increase of butyrylcholinesterase (BChE) in the later AD stages. B
Externí odkaz:
https://doaj.org/article/8753f9e020ec4afba27fb390b5193167
Publikováno v:
Marine Drugs, Vol 20, Iss 11, p 662 (2022)
Alzheimer’s disease (AD) is a complex and progressive disease, which affects millions of people around the world. Despite the many efforts over the years to find efficient therapeutics, there is no cure yet. Nonetheless, many compounds have been pr
Externí odkaz:
https://doaj.org/article/99b29f411cea448c81e73f161262e006
Publikováno v:
Molecules, Vol 27, Iss 5, p 1677 (2022)
Marine organisms are an important source of natural products with unique and diverse chemical structures that may hold the key for the development of novel drugs. Docosahexaenoic acid (DHA) is an omega-3 fatty acid marine natural product playing a cr
Externí odkaz:
https://doaj.org/article/5eed7310e8034f59a44a574c23c2c59c
Autor:
Catarina Dias, João P. Pais, Rafael Nunes, Maria-Teresa Blázquez-Sánchez, Joaquim T. Marquês, Andreia F. Almeida, Patrícia Serra, Nuno M. Xavier, Diogo Vila-Viçosa, Miguel Machuqueiro, Ana S. Viana, Alice Martins, Maria S. Santos, Ana Pelerito, Ricardo Dias, Rogério Tenreiro, Maria C. Oliveira, Marialessandra Contino, Nicola A. Colabufo, Rodrigo F. M. de Almeida, Amélia P. Rauter
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Bacillus anthracis causes the infectious disease anthrax. Here, the authors synthesized deoxy glycosides that are effective against B. anthracis and related bacteria and found that these amphiphilic compounds kill bacteria via an unusual mechanism of
Externí odkaz:
https://doaj.org/article/158158d4523442a69f2881aae2aca7d4
Autor:
Maria João Rodrigues, Luísa Custódio, Andreia Lopes, Marta Oliveira, Nuno R. Neng, José M. F. Nogueira, Alice Martins, Amélia P. Rauter, João Varela, Luísa Barreira
Publikováno v:
Pharmaceutical Biology, Vol 55, Iss 1, Pp 1348-1357 (2017)
Context: Several Polygonum species (Polygonaceae) are used in traditional medicine in Asia, Europe and Africa to treat inflammation and diabetes. Objective: Evaluate the in vitro antioxidant, anti-inflammatory and antidiabetic potential of methanol a
Externí odkaz:
https://doaj.org/article/0b977a6d296c4288a3d2250539348701
Autor:
Ana M. de Matos, Alice Martins, Teresa Man, David Evans, Magnus Walter, Maria Conceição Oliveira, Óscar López, José G. Fernandez-Bolaños, Philipp Dätwyler, Beat Ernst, M. Paula Macedo, Marialessandra Contino, Nicola A. Colabufo, Amélia P. Rauter
Publikováno v:
Pharmaceuticals, Vol 12, Iss 2, p 98 (2019)
With the lack of available drugs able to prevent the progression of Alzheimer’s disease (AD), the discovery of new neuroprotective treatments able to rescue neurons from cell injury is presently a matter of extreme importance and urgency. Here, we
Externí odkaz:
https://doaj.org/article/d85cea01c0e04efc9bf99088013d51b6