Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Am, Töglhofer"'
Autor:
Bf, Verhaaren, Debette S, Jc, Bis, Ja, Smith, Mk, Ikram, Hh, Adams, Ah, Beecham, Kb, Rajan, Lm, Lopez, Barral S, Ma, Buchem, van der Grond J, Av, Smith, Hegenscheid K, Nt, Aggarwal, de Andrade M, Ej, Atkinson, Beekman M, As, Beiser, Sh, Blanton, Boerwinkle E, Am, Brickman, Rn, Bryan, Chauhan G, Cp, Chen, Chouraki V, Aj, Craen, Crivello F, Ij, Deary, Deelen J, Pl, Jager, Dufouil C, Ms, Elkind, Da, Evans, Freudenberger P, Rf, Gottesman, Guðnason V, Habes M, Sr, Heckbert, Heiss G, Hilal S, Hofer E, Hofman A, Ca, Ibrahim-Verbaas, Ds, Knopman, Ce, Lewis, Liao J, Dc, Liewald, Luciano M, van der Lugt A, Oo, Martinez, Mayeux R, Mazoyer B, Ma, Nalls, Nauck M, Wj, Niessen, Ba, Oostra, Bm, Psaty, Km, Rice, Ji, Rotter, von Sarnowski B, Schmidt H, Pj, Schreiner, Schuur M, Ss, Sidney, Sigurdsson S, Pe, Slagboom, Dj, Stott, Jc, Swieten, Teumer A, Am, Töglhofer, Traylor M, Trompet S, St, Turner, Tzourio C, Hw, Uh, Ag, Uitterlinden, Mw, Vernooij, Jj, Wang, Ty, Wong, Jm, Wardlaw, Bg, Windham, Wittfeld K, Wolf C, Cb, Wright, Yang Q, Zhao W, Zijdenbos A, Jw, Jukema, Rl, Sacco, Sl, Kardia, Amouyel P, Th, Mosley, Wt, Longstreth Jr, Cc, Decarli, Cm, Duijn, Schmidt R, Lj, Launer, Hj, Grabe, Ss, Seshadri, Ma, Ikram, Fornage M
Publikováno v:
Europe PubMed Central
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a3113d3796b454ac9b7f1a85213d0598
http://europepmc.org/abstract/med/25663218
http://europepmc.org/abstract/med/25663218
Autor:
Wild PS, Felix JF, Schillert A, Teumer A, Chen MH, Leening MJG, Völker U, Großmann V, Brody JA, Irvin MR, Shah SJ, Pramana S, Lieb W, Schmidt R, Stanton AV, Malzahn D, Smith AV, Sundström J, Minelli C, Ruggiero D, Lyytikäinen LP, Tiller D, Smith JG, Monnereau C, Di Tullio MR, Musani SK, Morrison AC, Pers TH, Morley M, Kleber ME, Aragam J, Benjamin EJ, Bis JC, Bisping E, Broeckel U, Cheng S, Deckers JW, Del Greco M F, Edelmann F, Fornage M, Franke L, Friedrich N, Harris TB, Hofer E, Hofman A, Huang J, Hughes AD, Kähönen M, Investigators K, Kruppa J, Lackner KJ, Lannfelt L, Laskowski R, Launer LJ, Leosdottir M, Lin H, Lindgren CM, Loley C, MacRae CA, Mascalzoni D, Mayet J, Medenwald D, Morris AP, Müller C, Müller-Nurasyid M, Nappo S, Nilsson PM, Nuding S, Nutile T, Peters A, Pfeufer A, Pietzner D, Pramstaller PP, Raitakari OT, Rice KM, Rivadeneira F, Rotter JI, Ruohonen ST, Sacco RL, Samdarshi TE, Schmidt H, Sharp ASP, Shields DC, Sorice R, Sotoodehnia N, Stricker BH, Surendran P, Thom S, Töglhofer AM, Uitterlinden AG, Wachter R, Völzke H, Ziegler A, Münzel T, März W, Cappola TP, Hirschhorn JN, Mitchell GF, Smith NL, Fox ER, Dueker ND, Jaddoe VWV, Melander O, Russ M, Lehtimäki T, Ciullo M, Hicks AA, Lind L, Gudnason V, Pieske B, Barron AJ, Zweiker R, Schunkert H, Ingelsson E, Liu K, Arnett DK, Psaty BM, Blankenberg S, Larson MG, Felix SB, Franco OH, Zeller T, Vasan RS, Dörr M
Publikováno v:
The Journal of clinical investigation [J Clin Invest] 2017 May 01; Vol. 127 (5), pp. 1798-1812. Date of Electronic Publication: 2017 Apr 10.
Autor:
Freudenberger P; From the Institute of Molecular Biology and Biochemistry, Center for Molecular Medicine (P.F., A.M.T., A.F., H.S.), Department of Neurology (K.P., E.H., R.S., H.S.), Institute for Medical Informatics, Statistics and Documentation (E.H.), and Department of Cardiology (S.P., R.Z.), Medical University of Graz, Austria; Department of Public Health and General Practice (A.S.), Faculty of Medicine, Norwegian University of Science and Technology, Norway; and Department of Neurology (S.S.), Boston University School of Medicine, MA., Petrovic K; From the Institute of Molecular Biology and Biochemistry, Center for Molecular Medicine (P.F., A.M.T., A.F., H.S.), Department of Neurology (K.P., E.H., R.S., H.S.), Institute for Medical Informatics, Statistics and Documentation (E.H.), and Department of Cardiology (S.P., R.Z.), Medical University of Graz, Austria; Department of Public Health and General Practice (A.S.), Faculty of Medicine, Norwegian University of Science and Technology, Norway; and Department of Neurology (S.S.), Boston University School of Medicine, MA., Sen A; From the Institute of Molecular Biology and Biochemistry, Center for Molecular Medicine (P.F., A.M.T., A.F., H.S.), Department of Neurology (K.P., E.H., R.S., H.S.), Institute for Medical Informatics, Statistics and Documentation (E.H.), and Department of Cardiology (S.P., R.Z.), Medical University of Graz, Austria; Department of Public Health and General Practice (A.S.), Faculty of Medicine, Norwegian University of Science and Technology, Norway; and Department of Neurology (S.S.), Boston University School of Medicine, MA., Töglhofer AM; From the Institute of Molecular Biology and Biochemistry, Center for Molecular Medicine (P.F., A.M.T., A.F., H.S.), Department of Neurology (K.P., E.H., R.S., H.S.), Institute for Medical Informatics, Statistics and Documentation (E.H.), and Department of Cardiology (S.P., R.Z.), Medical University of Graz, Austria; Department of Public Health and General Practice (A.S.), Faculty of Medicine, Norwegian University of Science and Technology, Norway; and Department of Neurology (S.S.), Boston University School of Medicine, MA., Fixa A; From the Institute of Molecular Biology and Biochemistry, Center for Molecular Medicine (P.F., A.M.T., A.F., H.S.), Department of Neurology (K.P., E.H., R.S., H.S.), Institute for Medical Informatics, Statistics and Documentation (E.H.), and Department of Cardiology (S.P., R.Z.), Medical University of Graz, Austria; Department of Public Health and General Practice (A.S.), Faculty of Medicine, Norwegian University of Science and Technology, Norway; and Department of Neurology (S.S.), Boston University School of Medicine, MA., Hofer E; From the Institute of Molecular Biology and Biochemistry, Center for Molecular Medicine (P.F., A.M.T., A.F., H.S.), Department of Neurology (K.P., E.H., R.S., H.S.), Institute for Medical Informatics, Statistics and Documentation (E.H.), and Department of Cardiology (S.P., R.Z.), Medical University of Graz, Austria; Department of Public Health and General Practice (A.S.), Faculty of Medicine, Norwegian University of Science and Technology, Norway; and Department of Neurology (S.S.), Boston University School of Medicine, MA., Perl S; From the Institute of Molecular Biology and Biochemistry, Center for Molecular Medicine (P.F., A.M.T., A.F., H.S.), Department of Neurology (K.P., E.H., R.S., H.S.), Institute for Medical Informatics, Statistics and Documentation (E.H.), and Department of Cardiology (S.P., R.Z.), Medical University of Graz, Austria; Department of Public Health and General Practice (A.S.), Faculty of Medicine, Norwegian University of Science and Technology, Norway; and Department of Neurology (S.S.), Boston University School of Medicine, MA., Zweiker R; From the Institute of Molecular Biology and Biochemistry, Center for Molecular Medicine (P.F., A.M.T., A.F., H.S.), Department of Neurology (K.P., E.H., R.S., H.S.), Institute for Medical Informatics, Statistics and Documentation (E.H.), and Department of Cardiology (S.P., R.Z.), Medical University of Graz, Austria; Department of Public Health and General Practice (A.S.), Faculty of Medicine, Norwegian University of Science and Technology, Norway; and Department of Neurology (S.S.), Boston University School of Medicine, MA., Seshadri S; From the Institute of Molecular Biology and Biochemistry, Center for Molecular Medicine (P.F., A.M.T., A.F., H.S.), Department of Neurology (K.P., E.H., R.S., H.S.), Institute for Medical Informatics, Statistics and Documentation (E.H.), and Department of Cardiology (S.P., R.Z.), Medical University of Graz, Austria; Department of Public Health and General Practice (A.S.), Faculty of Medicine, Norwegian University of Science and Technology, Norway; and Department of Neurology (S.S.), Boston University School of Medicine, MA., Schmidt R; From the Institute of Molecular Biology and Biochemistry, Center for Molecular Medicine (P.F., A.M.T., A.F., H.S.), Department of Neurology (K.P., E.H., R.S., H.S.), Institute for Medical Informatics, Statistics and Documentation (E.H.), and Department of Cardiology (S.P., R.Z.), Medical University of Graz, Austria; Department of Public Health and General Practice (A.S.), Faculty of Medicine, Norwegian University of Science and Technology, Norway; and Department of Neurology (S.S.), Boston University School of Medicine, MA., Schmidt H; From the Institute of Molecular Biology and Biochemistry, Center for Molecular Medicine (P.F., A.M.T., A.F., H.S.), Department of Neurology (K.P., E.H., R.S., H.S.), Institute for Medical Informatics, Statistics and Documentation (E.H.), and Department of Cardiology (S.P., R.Z.), Medical University of Graz, Austria; Department of Public Health and General Practice (A.S.), Faculty of Medicine, Norwegian University of Science and Technology, Norway; and Department of Neurology (S.S.), Boston University School of Medicine, MA. helena.schmidt@medunigraz.at.
Publikováno v:
Neurology [Neurology] 2016 Feb 02; Vol. 86 (5), pp. 418-24. Date of Electronic Publication: 2016 Jan 06.
Autor:
Hofer E; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Cavalieri M; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Bis JC; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, DeCarli C; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Fornage M; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Sigurdsson S; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Srikanth V; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Trompet S; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Verhaaren BF; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Wolf C; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Yang Q; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Adams HH; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Amouyel P; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Beiser A; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Buckley BM; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Callisaya M; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Chauhan G; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, de Craen AJ; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Dufouil C; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, van Duijn CM; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Ford I; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Freudenberger P; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Gottesman RF; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Gudnason V; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Heiss G; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Hofman A; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Lumley T; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Martinez O; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Mazoyer B; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Moran C; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Niessen WJ; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Phan T; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Psaty BM; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Satizabal CL; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Sattar N; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Schilling S; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Shibata DK; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Slagboom PE; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Smith A; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Stott DJ; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Taylor KD; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Thomson R; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Töglhofer AM; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Tzourio C; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, van Buchem M; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Wang J; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Westendorp RG; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Windham BG; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Vernooij MW; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Zijdenbos A; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Beare R; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Debette S; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Ikram MA; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Jukema JW; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Launer LJ; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Longstreth WT Jr; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Mosley TH; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Seshadri S; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Schmidt H; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F, Schmidt R; From the Department of Neurology (E.H., M.C., H.S., R.S.) and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Graz, Austria; Cardiovascular Health Research Unit, Departments of Medicine (J.C.B., B.M.P.), Radiology (D.K.S.), and Neurology and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento (C.D.C., O.M.); Brown Foundation Institute of Molecular Medicine (M.F.) and Human Genetics Center (M.F.), University of Texas Health Science Center, Houston; Icelandic Heart Association, Kopavogur, Iceland (S.S., V.G., A.S.); Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (V.S., M.C., C.M., T.P., R.B.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.C., R.G.J.W.), Molecular Epidemiology (P.E.S.), and Radiology (M.B.), Leiden University Medical Center, Leiden, The Netherlands; Departments of Epidemiology (B.F.J.V., H.H.H.A., C.M.D., A.H., M.W.V., M.A.I.), Radiology (B.F.J.V., H.H.H.A., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; INSERM U897 (C.W., G.C., C.D., S.S., S.D.), CNRS-CEA UMR5296 (B.M.), and INSERM U708 (C.T.), Université Bordeaux Segalen, Bordeaux, France; Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany (C.W.); Department of Biostatistics, Boston University School of Public Health, MA (Q.Y., A.B., J.W.); INSERM U744, Pasteur Institute, Lille, France (P.A.); Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland (B.M.B.); INSERM U1161 and Lariboisière Hospital, Paris 7 University, Paris, France (G.C., S.S., S.D.); Centre for Medical Systems Biology, Leiden, The Netherlands (C.M.D.); Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom (I.F
Publikováno v:
Stroke [Stroke] 2015 Nov; Vol. 46 (11), pp. 3048-57. Date of Electronic Publication: 2015 Oct 08.
Autor:
Joshi PK; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Esko T; Estonian Genome Center, University of Tartu, Riia 23b, 51010, Tartu, Estonia.; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Cambridge, 02141, MA, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge Center 7, Cambridge, 02242, MA, USA.; Department of Genetics, Harvard Medical School, 25 Shattuck St, Boston, 02115, MA, USA., Mattsson H; Unit of Public Health Genomics, National Institute for Health and Welfare, P.O. Box 104, Helsinki, FI-00251, Finland.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, P.O. Box 20, Helsinki, FI-00014, Finland., Eklund N; Unit of Public Health Genomics, National Institute for Health and Welfare, P.O. Box 104, Helsinki, FI-00251, Finland., Gandin I; Department of Medical Sciences, University of Trieste, Strada di Fiume 447 - Osp. di Cattinara, Trieste, 34149, Italy., Nutile T; Institute of Genetics and Biophysics 'A. Buzzati-Traverso' CNR, via Pietro Castellino, 111, Naples, 80131, Italy., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, 48109, MI, USA., Schurmann C; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, 10029, USA.; The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, 10029, USA., Smith AV; Icelandic Heart Association, Holtasmari 1, 201, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, W2 1PG, UK.; Department of Cardiology, Ealing Hospital NHS Trust, Uxbridge Road, Southall, Middlesex, UB1 3HW, UK., Okada Y; Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyoku, Tokyo, 113-8510, Japan.; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan., Stančáková A; Department of Medicine, University of Eastern Finland, 70210 Kuopio, Finland., Faul JD; Institute for Social Research, University of Michigan, 426 Thompson Street, 48104, Ann Arbor, MI, USA., Zhao W; Department of Epidemiology, University of Michigan, 1415 Washington Heights, 48109, Ann Arbor, MI, USA., Bartz TM; Cardiovascular Health Research Unit, Departments of Biostatistics and Medicine, University of Washington, 1730 Minor Ave, Suite 1360, Seattle, 98101, WA, USA., Concas MP; Institute of Population Genetics, National Research Council, Trav. La Crucca n. 3 - Reg. Baldinca, Sassari, 07100, Italy., Franceschini N; Epidemiology, University of North Carolina, 137 E. Franklin St., Suite 306, 27599-8050, Chapel Hill, USA., Enroth S; Immunology, Genetics & Pathology, Uppsala University, Husargatan 3, Box 815, Uppsala, SE-751 08, Sweden., Vitart V; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, EH4 2XU, Edinburgh, UK., Trompet S; Department of Gerontology and Geriatrics, Leiden University Medical Center , PO Box 9600, Leiden, Netherlands., Guo X; Institute for Translational Genomics and Population Sciences , Los Angeles Biomedical Research Institute, 1124 W. Carson Street, Torrance, 90502, USA.; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, 90502, USA., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Avenue, East, Harvard Medical School, Boston, Boston, MA 02215, USA., O'Connel JR; Division of Endocrinology, Diabetes, and Nutrition and Program for Personalised and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, 685 Baltimore St. MSTF, Baltimore, 21201, USA., Corre T; Department of Medical Genetics, University of Lausanne, Rue du Bugnon 27, Lausanne, 1005, Switzerland.; Swiss Institute of Bioinformatics, Quartier Sorge - batiment génopode, Lausanne, 1015, Switzerland., Nongmaithem SS; Genomic Research on Complex Diseases (GRC) Group, CSIR-Centre for Cellular and Molecular Biology, Habshiguda, Uppal Road, Hyderabad, 500007, India., Chen Y; Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Avenue, Boston, 02118, MA, USA., Mangino M; Department of Twin Research & Genetic Epidemiology, King's College London, South Wing, Block D, 3rd Floor, Westminster Bridge Road, London, SE1 7EH, UK.; NIHR Biomedical Research Centre , Guy's and St. Thomas' Foundation Trust, Westminster Bridge Road, London, SE1 7EH, UK., Ruggiero D; Institute of Genetics and Biophysics 'A. Buzzati-Traverso' CNR, via Pietro Castellino, 111, Naples, 80131, Italy., Traglia M; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Via Olgettina 58, Milano, 20132, Italy., Farmaki AE; Department of Nutrition and Dietetics, Harokopio University of Athens, 70, El. Venizelou Ave, Athens, 17671, Greece., Kacprowski T; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Friedrich-Ludwig-Jahn-Str. 15A, Greifswald, 17475, Germany., Bjonnes A; Center for Human Genetic Research , 55 Fruit Street, Massachusetts General Hospital, 2114, USA., van der Spek A; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, Rotterdam, 3000 CA, The Netherlands., Wu Y; Department of Genetics, University of North Carolina, Chapel Hill, 27599, NC, USA., Giri AK; Genomics and Molecular Medicine, CSIR-Institute of Genomics & Integrative Biology, Mathura Road, New Delhi, 110025, India., Yanek LR; The GeneSTAR Research Program, Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, 21287, Maryland, USA., Wang L; Department of Genetics, Washington University School of Medicine, 4444 Forest Park Boulevard, Saint Louis, 63108, MO, USA., Hofer E; Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Auenbruggerplatz 22, Graz, A-8036, Austria.; Institute for Medical Informatics, Statistics and Documentation, Medical University Graz, Auenbruggerplatz2, Graz, A-8036, Austria., Rietveld CA; Erasmus School of Economics, Erasmus University Rotterdam, Burgemeester Oudlaan 50, Rotterdam, 3000 DR, The Netherlands., McLeod O; Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, CMM L8:03, Karolinska University Hospital, Solna, Stockholm, 171 76, Sweden., Cornelis MC; Channing Division of Network Medicine, Brigham & Women's Hospital, 181 Longwood, Boston, 02115, USA.; Nutrition, Harvard School of Public Health, 401 Park Drive, Boston, 02215, USA., Pattaro C; Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany., Verweij N; University of Groningen, University Medical Center Groningen, Department of Cardiology, Hanzeplein 1, Groningen, 9700RB, The Netherlands., Baumbach C; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, Neuherberg, 85764, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, Neuherberg, 85764, Germany.; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, Neuherberg, 85764, Germany., Abdellaoui A; Department of Biological Psychology, VU University Amsterdam, Van der Boechorststraat 1, 1081 BT, Amsterdam, Netherlands., Warren HR; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.; NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK., Vuckovic D; Department of Medical Sciences, University of Trieste, Strada di Fiume 447 - Osp. di Cattinara, Trieste, 34149, Italy., Mei H; Department of Medicine, University of Mississippi Medical Center, 2500 N. State St., Jackson, 39216, MS, USA., Bouchard C; Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA., Perry JRB; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Cappellani S; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', via dell'Istria 65, Trieste, 34137, Italy., Mirza SS; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, Rotterdam, 3000 CA, The Netherlands., Benton MC; Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, GPO Box 2434, Brisbane Qld 4001, Brisbane, Australia., Broeckel U; Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, 53226, WI, USA., Medland SE; Quantitative Genetics, QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, Brisbane, 4006, Australia., Lind PA; Quantitative Genetics, QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, Brisbane, 4006, Australia., Malerba G; Dipartimento di Scienze della Vita e della Riproduzione, University of Verona, Strada Le Grazie 15, Verona, 37134, Italy., Drong A; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK., Yengo L; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Lille 2 University, 1 Rue du Professeur Calmette, 59000, Lille, France., Bielak LF; Department of Epidemiology, University of Michigan, 1415 Washington Heights, 48109, Ann Arbor, MI, USA., Zhi D; Department of Biostatistics, University of Alabama at Birmingham, 1665 University Blvd, Birmingham, 35294, AL, USA., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, P.O. box 30.001, 9700 RB, Groningen, The Netherlands., Shriner D; Center for Research on Genomics and Global Health, National Human Genome Research Institute, Building 12A/Room 4047, 12 South Dr., Bethesda, 20892, Maryland, USA., Mägi R; Estonian Genome Center, University of Tartu, Riia 23b, 51010, Tartu, Estonia., Hemani G; MRC Integrative Epidemiology Unit, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK., Karaderi T; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK., Wang Z; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Rockville, 20850, MD, USA.; Cancer Genomics Research Laboratory, National Cancer Institute, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick,MD, USA., Liu T; Center for Lifespan Psychology, Max Planck Institute for Human Development, Lentzeallee 94, Berlin, 14195, Germany.; Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestr. 72, Berlin, 14195, Germany., Demuth I; Charité Research Group on Geriatrics, Charité - Universitätsmedizin Berlin, Reinickendorferstr. 61, 13347, Berlin, Germany.; Institute of Medical and Human Genetics, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, Berlin, 13353, Germany., Zhao JH; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Meng W; Division of Population Health Sciences, Medical Research Institute, University of Dundee, Ninewells hospital and School of Medicine, Dundee, DD2 4BF, Scotland., Lataniotis L; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK., van der Laan SW; Experimental Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, 3584 CX, The Netherlands., Bradfield JP; Center for Applied Genomics, Children's Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA., Wood AR; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK., Bonnefond A; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Lille 2 University, 1 Rue du Professeur Calmette, 59000, Lille, France., Ahluwalia TS; Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Danish Pediatric Asthma Center, Gentofte Hospital, The Capital Region, Copenhagen, Denmark.; Novo Nordisk Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 1, Copenhagen, 2100, Denmark., Hall LM; Department of Cardiovascular Sciences, University of Leicester, BHF Cardiovascular Research Centre, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK., Salvi E; Department of Health Sciences, University of Milan, via A. di Rudinì 8, 20142 Milan, Italy., Yazar S; Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, 2 Verdun St, Perth, 6009, Australia., Carstensen L; Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, Copenhagen, 2300, Denmark., de Haan HG; Clinical Epidemiology, Leiden University Medical Center, PO Box 9600, Leiden, 2300RC, The Netherlands., Abney M; Department of Human Genetics, University of Chicago, 920 E. 58th Street, Chicago, IL, USA., Afzal U; Department of Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, W2 1PG, UK.; Department of Cardiology, Ealing Hospital NHS Trust, Uxbridge Road, Southall, Middlesex, UB1 3HW, UK., Allison MA; Department of Family and Preventive Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, 92093, USA., Amin N; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, Rotterdam, 3000 CA, The Netherlands., Asselbergs FW; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, 3584 CX, The Netherlands.; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Catharijnesingel 52, Utrecht, 3501 DG, The Netherlands.; Institute of Cardiovascular Science, faculty of Population Health Sciences, University College London, Gower Street, London, WC1E 6BT, UK., Bakker SJL; University of Groningen, University Medical Center Groningen, Department of Internal Medicine, Hanzeplein 1, Groningen, 9700RB, The Netherlands., Barr RG; Department of Medicine, Columbia University, 622 W. 168th Street, New York, 10032, NY, USA., Baumeister SE; Institute for Community Medicine, University Medicine Greifswald, W.-Rathenau-Str. 48, Greifswald, 17475, Germany., Benjamin DJ; Department of Economics, Cornell University, 480 Uris Hall, Ithaca, NY, 14853, USA.; Department of Economics and Center for Economic and Social Research, University of Southern California, 314C Dauterive Hall, 635 Downey Way, Los Angeles, CA, 90089, USA., Bergmann S; Department of Medical Genetics, University of Lausanne, Rue du Bugnon 27, Lausanne, 1005, Switzerland.; Swiss Institute of Bioinformatics, Quartier Sorge - batiment génopode, Lausanne, 1015, Switzerland., Boerwinkle E; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, 1200 Pressler St., Suite 453E, Houston, Texas, 77030, USA., Bottinger EP; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, 10029, USA., Campbell A; Centre for Genomic and Experimental Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK., Chakravarti A; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, 21205, MD, USA., Chan Y; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Cambridge, 02141, MA, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge Center 7, Cambridge, 02242, MA, USA.; Department of Genetics, Harvard Medical School, 25 Shattuck St, Boston, 02115, MA, USA., Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Rockville, 20850, MD, USA., Chen C; Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, 665 Huntington Ave, Boston, 02115, USA., Chen YI; Institute for Translational Genomics and Population Sciences , Los Angeles Biomedical Research Institute, 1124 W. Carson Street, Torrance, 90502, USA.; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, 90502, USA., Collins FS; Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, 20892, MD, USA., Connell J; College of Medicine, Dentistry and Nursing, Ninewells Hospital and Medical School, College Office, Level 10, Dundee, DD1 9SY, UK., Correa A; Department of Medicine, University of Mississippi Medical Center, 2500 N. State St., Jackson, 39216, MS, USA., Cupples LA; Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Avenue, Boston, 02118, MA, USA.; National Heart, Lung, and Blood Institute's Framingham Heart Study, 73 Mt. Wayte Ave, Framingham, 01702, MA, USA., Smith GD; MRC Integrative Epidemiology Unit, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK., Davies G; Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK., Dörr M; Department of Internal Medicine B, University Medicine Greifswald, Ferdinand-Sauerbruch-Str. NK, Greifswald, 17475, Germany., Ehret G; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, 21205, MD, USA.; Cardiology, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, 4, Genève 14, 1211, Switzerland., Ellis SB; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, 10029, USA., Feenstra B; Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, Copenhagen, 2300, Denmark., Feitosa MF; Department of Genetics, Washington University School of Medicine, 4444 Forest Park Boulevard, Saint Louis, 63108, MO, USA., Ford I; Robertson Centre, University of Glasgow, Boyd Orr Building, Glasgow, G12 8QQ, Scotland., Fox CS; National Heart, Lung, and Blood Institute's Framingham Heart Study, 73 Mt. Wayte Ave, Framingham, 01702, MA, USA.; Division of Endocrinology, Brigham and Women's Hospital and Harvard Medical School , 75 Francis St, Boston, 02115, MA, USA., Frayling TM; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK., Friedrich N; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Str. NK, 17475, Greifswald, Germany., Geller F; Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, Copenhagen, 2300, Denmark., Scotland G; Centre for Genomic and Experimental Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK., Gillham-Nasenya I; Department of Twin Research & Genetic Epidemiology, King's College London, South Wing, Block D, 3rd Floor, Westminster Bridge Road, London, SE1 7EH, UK., Gottesman O; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, 10029, USA., Graff M; Epidemiology, University of North Carolina, 137 E Franklin St., Suite 306, USA., Grodstein F; Nutrition, Harvard School of Public Health, 401 Park Drive, Boston, 02215, USA., Gu C; Division of Biostatistics, Washington University, 660 S Euclid, St Louis, 63110, MO, USA., Haley C; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, EH4 2XU, Edinburgh, UK.; Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, Scotland., Hammond CJ; Department of Twin Research & Genetic Epidemiology, King's College London, South Wing, Block D, 3rd Floor, Westminster Bridge Road, London, SE1 7EH, UK., Harris SE; Centre for Genomic and Experimental Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK., Harris TB; National Institutes on Aging, National Institutes of Health, Bethesda, MD, USA., Hastie ND; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, EH4 2XU, Edinburgh, UK., Heard-Costa NL; National Heart, Lung, and Blood Institute's Framingham Heart Study, 73 Mt. Wayte Ave, Framingham, 01702, MA, USA.; Department of Neurology, Boston University School of Medicine, 72 E Concord St, Boston, 02118, MA, USA., Heikkilä K; Department of Public Health, University of Helsinki, Hjelt Institute, P.O.Box 41, Mannerheimintie 172, Helsinki, FI-00014, Finland., Hocking LJ; Musculoskeletal Research Programme, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK., Homuth G; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Friedrich-Ludwig-Jahn-Str. 15A, Greifswald, 17475, Germany., Hottenga JJ; Department of Biological Psychology, VU University Amsterdam, Van der Boechorststraat 1, 1081 BT, Amsterdam, Netherlands., Huang J; State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Er Road, Shanghai, 200025 China., Huffman JE; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, EH4 2XU, Edinburgh, UK., Hysi PG; Department of Twin Research & Genetic Epidemiology, King's College London, South Wing, Block D, 3rd Floor, Westminster Bridge Road, London, SE1 7EH, UK., Ikram MA; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, Rotterdam, 3000 CA, The Netherlands.; Department of Radiology, Erasmus Medical Center, PO Box 2040, Rotterdam, 3000 CA, The Netherlands., Ingelsson E; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Joensuu A; Unit of Public Health Genomics, National Institute for Health and Welfare, P.O. Box 104, Helsinki, FI-00251, Finland.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, P.O. Box 20, Helsinki, FI-00014, Finland., Johansson Å; Immunology, Genetics & Pathology, Uppsala University, Husargatan 3, Box 815, Uppsala, SE-751 08, Sweden.; Uppsala Clinical Research Center, Uppsala University, Uppsala, SE-75237, Sweden., Jousilahti P; Department of Chronic Disease Prevention, National Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland., Jukema JW; Department of Cardiology C5-P , Leiden University Medical Center, PO Box 9600, Leiden, Netherlands., Kähönen M; Department of Clinical Physiology, University of Tampere and Tampere University Hospital, P.O. Box 2000, Tampere, 33521, Finland., Kamatani Y; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan., Kanoni S; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK., Kerr SM; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, EH4 2XU, Edinburgh, UK., Khan NM; Genomics and Molecular Medicine, CSIR-Institute of Genomics & Integrative Biology, Mathura Road, New Delhi, 110025, India., Koellinger P; Erasmus School of Economics, Erasmus University Rotterdam, Burgemeester Oudlaan 50, Rotterdam, 3000 DR, The Netherlands., Koistinen HA; Diabetes Prevention Unit, National Institute for Health and Welfare, P.O. Box 30, FI-00271 Helsinki, Finland.; Department of Medicine, Division of Endocrinology, Helsinki University Central Hospital, P.O.Box 340, Haartmaninkatu 4, Helsinki, FI-00029, Finland.; Minerva Foundation Institute for Medical Research, Biomedicum 2U, Tukholmankatu 8, Helsinki, FI-00290, Finland., Kooner MK; Department of Cardiology, Ealing Hospital NHS Trust, Uxbridge Road, Southall, Middlesex, UB1 3HW, UK., Kubo M; Laboratory for Genotyping Development RCfIMS, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan., Kuusisto J; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, 70210, Finland., Lahti J; Institute of Behavioural Sciences, University of Helsinki, P.O. Box 9, FI-00014 University of Helsinki, Helsinki, Finland.; Folkhälsan Reasearch Centre, PB 63, Helsinki, FI-00014 University of Helsinki, Finland., Launer LJ; National Institutes on Aging, National Institutes of Health, Bethesda, MD, USA., Lea RA; Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, GPO Box 2434, Brisbane Qld 4001, Brisbane, Australia., Lehne B; Department of Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, W2 1PG, UK., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine University of Tampere, Tampere, 33520, Finland., Liewald DCM; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK., Lind L; Department of Medical Sciences, University Hospital, Uppsala, 75185, Sweden., Loh M; Department of Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, W2 1PG, UK., Lokki ML; Transplantation laboratory, Haartman Institute, University of Helsinki, P.O. Box 21, Helsinki, FI-00014, Finland., London SJ; National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, RTP, NC, USA., Loomis SJ; Ophthalmology, Massachusetts Eye and Ear, 243 Charles St, Boston, 02114, USA., Loukola A; Department of Public Health, University of Helsinki, Hjelt Institute, P.O.Box 41, Mannerheimintie 172, Helsinki, FI-00014, Finland., Lu Y; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, 10029, USA.; The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, 10029, USA., Lumley T; Department of Statistics, University of Auckland, 303.325 Science Centre, Private Bag 92019, Auckland, 1142, New Zealand., Lundqvist A; Department of Health, Functional Capacity and Welfare, National Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland., Männistö S; Department of Chronic Disease Prevention, National Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland., Marques-Vidal P; Department of Internal Medicine, University Hospital, Route du Bugnon 44, Lausanne, 1011, Switzerland., Masciullo C; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Via Olgettina 58, Milano, 20132, Italy., Matchan A; Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH, UK., Mathias RA; The GeneSTAR Research Program, Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, 21287, Maryland, USA.; Division of Allergy and Clinical Immunology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21224, USA., Matsuda K; Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan., Meigs JB; Division of General Internal Medicine, Massachusetts General Hospital , 50 Staniford St, Boston, 02114, MA, USA., Meisinger C; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, Neuherberg, 85764, Germany., Meitinger T; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, Neuherberg, 85764 Germany.; Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, München, 81675, Germany., Menni C; Department of Twin Research & Genetic Epidemiology, King's College London, South Wing, Block D, 3rd Floor, Westminster Bridge Road, London, SE1 7EH, UK., Mentch FD; Center for Applied Genomics, Children's Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA., Mihailov E; Estonian Genome Center, University of Tartu, Riia 23b, 51010, Tartu, Estonia., Milani L; Estonian Genome Center, University of Tartu, Riia 23b, 51010, Tartu, Estonia., Montasser ME; Division of Endocrinology, Diabetes, and Nutrition and Program for Personalised and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, 685 Baltimore St. MSTF, Baltimore, 21201, USA., Montgomery GW; Molecular Epidemiology, QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, Brisbane, 4006, Australia., Morrison A; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, 1200 Pressler St., Suite 453E, Houston, Texas, 77030, USA., Myers RH; Genome Science Institute, Boston University School of Medicine, 72 East Concord Street, E-304, Boston, 2118, MA, USA., Nadukuru R; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, 10029, USA., Navarro P; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, EH4 2XU, Edinburgh, UK., Nelis M; Estonian Genome Center, University of Tartu, Riia 23b, 51010, Tartu, Estonia., Nieminen MS; HUCH Heart and Lung center, Helsinki University Central Hospital, P.O. Box 340, Helsinki, FI-00029, Finland., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, P.O. box 30.001, 9700 RB, Groningen, The Netherlands., O'Connor GT; National Heart, Lung, and Blood Institute's Framingham Heart Study, 73 Mt. Wayte Ave, Framingham, 01702, MA, USA.; Pulmonary Center and Department of Medicine, Boston University School of Medicine, 72 E Concord St, Boston, 02118, MA, USA., Ogunniyi A; Department of Medicine, University of Ibadan, Ibadan, Nigeria., Padmanabhan S; ICAMS, University of Glasgow, 126 University Way, Glasgow, G12 8TA, UK., Palmas WR; Department of Medicine, Columbia University, 622 W. 168th Street, New York, 10032, NY, USA., Pankow JS; Division of Epidemiology and Community Health , University of Minnesota , 1300 S 2nd Street, Minneapolis, 55454, USA., Patarcic I; Centre for Global Health and Department of Public Health, School of Medicine, University of Split, Soltanska 2, 21000 Split, Croatia., Pavani F; Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany., Peyser PA; Department of Epidemiology, University of Michigan, 1415 Washington Heights, 48109, Ann Arbor, MI, USA., Pietilainen K; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, P.O. Box 20, Helsinki, FI-00014, Finland.; Department of Medicine, Division of Endocrinology, Helsinki University Central Hospital, P.O.Box 340, Haartmaninkatu 4, Helsinki, FI-00029, Finland.; Obesity Research Unit, Research Programs Unit, Diabetes and Obesity, University of Helsinki, P.O.Box 63, Haartmaninkatu 8, FI-00014, Helsinki, Finland., Poulter N; International Centre for Circulatory Health, Imperial College London, London, W2 1LA, UK., Prokopenko I; Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, SW7 2AZ, UK., Ralhan S; Department of Cardiology and Cardio thoracic Surgery Hero DMC Heart Institute, Civil Lines, 141001, Ludhiana, India., Redmond P; Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK., Rich SS; Department Public Health Sciences, University of Virginia School of Medicine, 3232 West Complex, Charlottesville, 22908, USA., Rissanen H; Department of Health, Functional Capacity and Welfare, National Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland., Robino A; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', via dell'Istria 65, Trieste, 34137, Italy., Rose LM; Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Avenue, East, Harvard Medical School, Boston, Boston, MA 02215, USA., Rose R; Department of Psychological & Brain Sciences, Indiana University Bloomington, 1101 E. 10th St., Bloomington, IN 47405, USA., Sala C; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Via Olgettina 58, Milano, 20132, Italy., Salako B; Department of Medicine, University of Ibadan, Ibadan, Nigeria., Salomaa V; Department of Chronic Disease Prevention, National Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland., Sarin AP; Unit of Public Health Genomics, National Institute for Health and Welfare, P.O. Box 104, Helsinki, FI-00251, Finland.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, P.O. Box 20, Helsinki, FI-00014, Finland., Saxena R; Center for Human Genetic Research , 55 Fruit Street, Massachusetts General Hospital, 2114, USA., Schmidt H; Institute of Molecular Biology and Biochemistry, Medical University Graz, Harrachgasse 21, Graz, A-8010, Austria., Scott LJ; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, 48109, MI, USA., Scott WR; Department of Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, W2 1PG, UK.; Department of Cardiology, Ealing Hospital NHS Trust, Uxbridge Road, Southall, Middlesex, UB1 3HW, UK., Sennblad B; Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, CMM L8:03, Karolinska University Hospital, Solna, Stockholm, 171 76, Sweden.; Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden., Seshadri S; National Heart, Lung, and Blood Institute's Framingham Heart Study, 73 Mt. Wayte Ave, Framingham, 01702, MA, USA.; Department of Neurology, Boston University School of Medicine, 72 E Concord St, Boston, 02118, MA, USA., Sever P; International Centre for Circulatory Health, Imperial College London, London, W2 1LA, UK., Shrestha S; Genomic Research on Complex Diseases (GRC) Group, CSIR-Centre for Cellular and Molecular Biology, Habshiguda, Uppal Road, Hyderabad, 500007, India., Smith BH; University of Dundee, Kirsty Semple Way, Dundee, DD2 4DB, UK., Smith JA; Department of Epidemiology, University of Michigan, 1415 Washington Heights, 48109, Ann Arbor, MI, USA., Soranzo N; Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH, UK., Sotoodehnia N; Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, 1730 Minor Ave, Suite 1360, Seattle, 98101, WA, USA., Southam L; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.; Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH, UK., Stanton AV; Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St. Stephen's Green, Dublin 2, Ireland., Stathopoulou MG; UMR INSERM U1122; IGE-PCV 'Interactions Gène-Environnement en Physiopathologie Cardio-Vasculaire', INSERM, University of Lorraine, 30 Rue Lionnois, Nancy, 54000, France., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, Neuherberg, 85764, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany., Strawbridge RJ; Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, CMM L8:03, Karolinska University Hospital, Solna, Stockholm, 171 76, Sweden., Suderman MJ; MRC Integrative Epidemiology Unit, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK., Tandon N; Department of Endocrinology, All India Institute of Medical Sciences, Ansari Nagar East, New Delhi, 110029, India., Tang ST; National Heart and Lung Institute, Imperial College London, Du Cane Road, London, W12 0NN, UK., Taylor KD; Institute for Translational Genomics and Population Sciences , Los Angeles Biomedical Research Institute, 1124 W. Carson Street, Torrance, 90502, USA.; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, 90502, USA., Tayo BO; Department of Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, Maywood, USA., Töglhofer AM; Institute of Molecular Biology and Biochemistry, Medical University Graz, Harrachgasse 21, Graz, A-8010, Austria., Tomaszewski M; Department of Cardiovascular Sciences, University of Leicester, BHF Cardiovascular Research Centre, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK.; NIHR Leicester Cardiovascular Biomedical Research Unit, University of Leicester, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK., Tšernikova N; Estonian Genome Center, University of Tartu, Riia 23b, 51010, Tartu, Estonia.; Institute of Molecular and Cell Biology, University of Tartu, Riia 23, Tartu, 51010 Estonia., Tuomilehto J; Diabetes Prevention Unit, National Institute for Health and Welfare, P.O. Box 30, FI-00271 Helsinki, Finland.; Centre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria.; Diabetes Research Group, King Abdulaziz University, 21589 Jeddah, Saudi Arabia., Uitterlinden AG; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, Rotterdam, 3000 CA, The Netherlands.; Department of Internal Medicine, Erasmus Medical Center, PO Box 2040, Rotterdam, 3000 CA, The Netherlands., Vaidya D; The GeneSTAR Research Program, Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, 21287, Maryland, USA.; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, 21205, USA., van Hylckama Vlieg A; Clinical Epidemiology, Leiden University Medical Center, PO Box 9600, Leiden, 2300RC, The Netherlands., van Setten J; Experimental Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, 3584 CX, The Netherlands., Vasankari T; Finnish Lung Health Association, Sibeliuksenkatu 11 A 1, Helsinki, FI-00250, Finland., Vedantam S; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Cambridge, 02141, MA, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge Center 7, Cambridge, 02242, MA, USA.; Department of Genetics, Harvard Medical School, 25 Shattuck St, Boston, 02115, MA, USA., Vlachopoulou E; Transplantation laboratory, Haartman Institute, University of Helsinki, P.O. Box 21, Helsinki, FI-00014, Finland., Vozzi D; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', via dell'Istria 65, Trieste, 34137, Italy., Vuoksimaa E; Department of Public Health, University of Helsinki, Hjelt Institute, P.O.Box 41, Mannerheimintie 172, Helsinki, FI-00014, Finland., Waldenberger M; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, Neuherberg, 85764, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, Neuherberg, 85764, Germany., Ware EB; Department of Epidemiology, University of Michigan, 1415 Washington Heights, 48109, Ann Arbor, MI, USA., Wentworth-Shields W; Department of Human Genetics, University of Chicago, 920 E. 58th Street, Chicago, IL, USA., Whitfield JB; Genetic Epidemiology, QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, Brisbane, 4006, Australia., Wild S; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Willemsen G; Department of Biological Psychology, VU University Amsterdam, Van der Boechorststraat 1, 1081 BT, Amsterdam, Netherlands., Yajnik CS; Diabetes Unit, KEM Hospital and Research Centre, Rasta Peth, Pune, 411011, India., Yao J; Institute for Translational Genomics and Population Sciences , Los Angeles Biomedical Research Institute, 1124 W. Carson Street, Torrance, 90502, USA., Zaza G; Renal Unit, Department of Medicine, Piazzale A. Stefani 1, Verona, 37124, Italy., Zhu X; Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, USA., Project TBJ; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan., Salem RM; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Cambridge, 02141, MA, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge Center 7, Cambridge, 02242, MA, USA.; Department of Genetics, Harvard Medical School, 25 Shattuck St, Boston, 02115, MA, USA., Melbye M; Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, Copenhagen, 2300, Denmark.; Department of Medicine, Stanford University, 300 Pasteur Drive, Stanford, 94305, CA, USA., Bisgaard H; Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Danish Pediatric Asthma Center, Gentofte Hospital, The Capital Region, Copenhagen, Denmark., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, BHF Cardiovascular Research Centre, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK.; NIHR Leicester Cardiovascular Biomedical Research Unit, University of Leicester, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK., Cusi D; Department of Health Sciences, University of Milan, via A. di Rudinì 8, 20142 Milan, Italy., Mackey DA; Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, 2 Verdun St, Perth, 6009, Australia., Cooper RS; Department of Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, Maywood, USA., Froguel P; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Lille 2 University, 1 Rue du Professeur Calmette, 59000, Lille, France.; Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, SW7 2AZ, UK., Pasterkamp G; Experimental Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, 3584 CX, The Netherlands., Grant SFA; Center for Applied Genomics, Children's Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA.; Department of Pediatrics, Perelman School of Medicine, The University of Pennsylvania, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA., Hakonarson H; Center for Applied Genomics, Children's Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA.; Department of Pediatrics, Perelman School of Medicine, The University of Pennsylvania, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA., Ferrucci L; Translational Gerontology Branch, National institute on Aging, Baltimore, 21225, Maryland, USA., Scott RA; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Morris AD; Jacqui Wood Cancer Centre, Medical Research Insitute, University of Dundee, Ninewells hospital and School of Medicine, Dundee, DD1 9SY, Scotland., Palmer CNA; Centre for Pharmacogenetics and Pharmacogenomics, Medical Research Institute, University of Dundee, Ninewells hospital and School of Medicine, Dundee, DD1 9SY, Scotland., Dedoussis G; Department of Nutrition and Dietetics, Harokopio University of Athens, 70, El. Venizelou Ave, Athens, 17671, Greece., Deloukas P; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, 21589, Saudi Arabia., Bertram L; Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestr. 72, Berlin, 14195, Germany.; Faculty of Medicine, Imperial College London, Charing Cross Campus - St Dunstan's Road, London, W6 8RP, UK., Lindenberger U; Center for Lifespan Psychology, Max Planck Institute for Human Development, Lentzeallee 94, Berlin, 14195, Germany., Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Rockville, 20850, MD, USA., Lindgren CM; Program in Medical and Population Genetics, Broad Institute, Cambridge Center 7, Cambridge, 02242, MA, USA.; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK., Timpson NJ; MRC Integrative Epidemiology Unit, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK., Tönjes A; Department of Medicine, University of Leipzig, Leipzig, Germany., Munroe PB; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.; NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK., Sørensen TIA; Novo Nordisk Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 1, Copenhagen, 2100, Denmark.; Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital , The Capital Region, Copenhagen, 2000, Denmark., Rotimi CN; Center for Research on Genomics and Global Health, National Human Genome Research Institute, Building 12A/Room 4047, 12 South Dr., Bethesda, 20892, Maryland, USA., Arnett DK; Department of Epidemiology, University of Alabama at Birmingham, 1665 University Blvd, Birmingham, 35294, AL, USA., Oldehinkel AJ; Department of Psychiatry, University Medical Center Groningen, University of Groningen, P.O. box 30.001, Groningen, 9700 RB, The Netherlands., Kardia SLR; Department of Epidemiology, University of Michigan, 1415 Washington Heights, 48109, Ann Arbor, MI, USA., Balkau B; Epidemiology of diabetes, obesity and chronic kidney disease over the lifecourse, Inserm, CESP Center for Research in Epidemiology and Population Health U1018, 16 Avenue Paul Vaillant Couturier, Villejuif, 94807, France., Gambaro G; Dipartimento di Scienze Mediche, Catholic University of the Sacred Heart, Via G. Moscati 31/34, Roma, 00168, Italy., Morris AP; Estonian Genome Center, University of Tartu, Riia 23b, 51010, Tartu, Estonia.; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.; Department of Biostatistics, University of Liverpool, Duncan Building, Daulby Stree, Liverpool, L69 3GA, UK., Eriksson JG; Department of Chronic Disease Prevention, National Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland.; Department of General Practice and Primary Health Care, University of Helsinki, P.O. Box 20, University of Helsinki, Helsinki, FI-00014, Finland.; Vasa Central Hospital, Sandviksgatan 2-4, Vasa, 65130, Finland.; Folkhälsan Reasearch Centre, PB 63, University of Helsinki, Helsinki, FI-00014, Finland.; Unit of General Practice, Helsinki University Central Hospital, Haartmaninkatu 4, Helsinki, FI-00290, Finland., Wright MJ; Neuro-Imaging Genetics, QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, Brisbane, 4006 Australia., Martin NG; Genetic Epidemiology, QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, Brisbane, 4006, Australia., Hunt SC; Cardiovascular Genetics Division, University of Utah, 420 Chipeta Way, Room 1160, Salt Lake City, 84117, Utah, USA., Starr JM; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.; Alzheimer Scotland Research Centre, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK., Deary IJ; Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK., Griffiths LR; Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, GPO Box 2434, Brisbane Qld 4001, Brisbane, Australia., Tiemeier H; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, Rotterdam, 3000 CA, The Netherlands.; Department of Psychiatry, Erasmus Medical Center, PO Box 2040, Rotterdam, 3000 CA, The Netherlands., Pirastu N; Department of Medical Sciences, University of Trieste, Strada di Fiume 447 - Osp. di Cattinara, Trieste, 34149, Italy.; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', via dell'Istria 65, Trieste, 34137, Italy., Kaprio J; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, P.O. Box 20, Helsinki, FI-00014, Finland.; Department of Public Health, University of Helsinki, Hjelt Institute, P.O.Box 41, Mannerheimintie 172, Helsinki, FI-00014, Finland.; National Institute for Health and Welfare (THL), P.O.Box 30, Mannerheimintie 166, Helsinki, FI-00271, Finland., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Pérusse L; Department of kinesiology, Laval University, 2300 rue de la Terrasse, Quebec, G1V 0A6, Canada., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 N. State St., Jackson, 39216, MS, USA., Girotto G; Department of Medical Sciences, University of Trieste, Strada di Fiume 447 - Osp. di Cattinara, Trieste, 34149, Italy., Caulfield MJ; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.; NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK., Raitakari O; Department of Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, 20521, Finland.; Research Center of Applied and Preventive Cardiovascular medicine, University of Turku, Turku, 20521, Finland., Boomsma DI; Department of Biological Psychology, VU University Amsterdam, Van der Boechorststraat 1, 1081 BT, Amsterdam, Netherlands., Gieger C; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, Neuherberg, 85764, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, Neuherberg, 85764, Germany.; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, Neuherberg, 85764, Germany., van der Harst P; University of Groningen, University Medical Center Groningen, Department of Cardiology, Hanzeplein 1, Groningen, 9700RB, The Netherlands.; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Catharijnesingel 52, Utrecht, 3501 DG, The Netherlands.; University of Groningen, University Medical Center Groningen, Department of Genetics, Hanzeplein 1, Groningen, 9700RB, The Netherlands., Hicks AA; Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany., Kraft P; Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, 665 Huntington Ave, Boston, 02115, USA., Sinisalo J; HUCH Heart and Lung center, Helsinki University Central Hospital, P.O. Box 340, Helsinki, FI-00029, Finland., Knekt P; Department of Health, Functional Capacity and Welfare, National Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland., Johannesson M; Department of Economics, Stockholm School of Economics, Box 6501, Stockholm, SE-113 83, Sweden., Magnusson PKE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, Stockholm, SE-171 77, Sweden., Hamsten A; Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, CMM L8:03, Karolinska University Hospital, Solna, Stockholm, 171 76, Sweden., Schmidt R; Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Auenbruggerplatz 22, Graz, A-8036, Austria., Borecki IB; Department of Genetics and Biostatistics, Washington University School of Medicine, 4444 Forest Park Boulevard, Saint Louis, 63108, MO, USA., Vartiainen E; Department of Chronic Disease Prevention, National Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland., Becker DM; The GeneSTAR Research Program, Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, 21287, Maryland, USA.; Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, 21205, Maryland, USA., Bharadwaj D; Genomics and Molecular Medicine, CSIR-Institute of Genomics & Integrative Biology, Mathura Road, New Delhi, 110025, India., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, 27599, NC, USA., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, 48109, MI, USA., van Duijn CM; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, Rotterdam, 3000 CA, The Netherlands., Sanghera DK; Department of Pediatrics, University of Oklahoma Health Sciences Center, 940 Stanton Young Boulevard, Oklahoma City, 73104, OK , USA.; Department of Pharmaceutical Sciences , University of Oklahoma Health Sceienecs Center, Oklahoma City , 73104, USA., Teumer A; Institute for Community Medicine, University Medicine Greifswald, W.-Rathenau-Str. 48, Greifswald, 17475, Germany., Zeggini E; Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH, UK., Metspalu A; Estonian Genome Center, University of Tartu, Riia 23b, 51010, Tartu, Estonia.; Institute of Molecular and Cell Biology, University of Tartu, Riia 23, Tartu, 51010 Estonia., Gasparini P; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', via dell'Istria 65, Trieste, 34137, Italy., Ulivi S; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', via dell'Istria 65, Trieste, 34137, Italy., Ober C; Department of Human Genetics, University of Chicago, 920 E. 58th Street, Chicago, IL, USA., Toniolo D; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Via Olgettina 58, Milano, 20132, Italy., Rudan I; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Porteous DJ; Centre for Genomic and Experimental Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK., Ciullo M; Institute of Genetics and Biophysics 'A. Buzzati-Traverso' CNR, via Pietro Castellino, 111, Naples, 80131, Italy., Spector TD; Department of Twin Research & Genetic Epidemiology, King's College London, South Wing, Block D, 3rd Floor, Westminster Bridge Road, London, SE1 7EH, UK., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, EH4 2XU, Edinburgh, UK., Dupuis J; Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Avenue, Boston, 02118, MA, USA.; National Heart, Lung, and Blood Institute's Framingham Heart Study, 73 Mt. Wayte Ave, Framingham, 01702, MA, USA., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, 10029, USA.; The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, 10029, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, 10029, USA., Wright AF; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, EH4 2XU, Edinburgh, UK., Chandak GR; Genomic Research on Complex Diseases (GRC) Group, CSIR-Centre for Cellular and Molecular Biology, Habshiguda, Uppal Road, Hyderabad, 500007, India.; Genome Institute of Singapore, 60 Biopolis Street, #02-01 Genome, Singapore, 138672, Singapore., Vollenweider P; Department of Internal Medicine, University Hospital, Route du Bugnon 44, Lausanne, 1011, Switzerland., Shuldiner A; Division of Endocrinology, Diabetes, and Nutrition and Program for Personalised and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, 685 Baltimore St. MSTF, Baltimore, 21201, USA.; Program for Personalised and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, 685 Baltimore St. MSTF, Baltimore, 21201, USA.; Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, 685 W Baltimore MSTF, Baltimore, 21201, USA., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Avenue, East, Harvard Medical School, Boston, Boston, MA 02215, USA., Rotter JI; Institute for Translational Genomics and Population Sciences , Los Angeles Biomedical Research Institute, 1124 W. Carson Street, Torrance, 90502, USA.; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, 90502, USA., Sattar N; BHF centre, University of Glasgow, 126 University Avenue, Glasgow, G12 8TA, Scotland., Gyllensten U; Immunology, Genetics & Pathology, Uppsala University, Husargatan 3, Box 815, Uppsala, SE-751 08, Sweden., North KE; Epidemiology, University of North Carolina, 137 E Franklin St., Suite 306, USA.; Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, 137 E. Franklin St., Suite 306, Chapel Hill, USA., Pirastu M; Institute of Population Genetics, National Research Council, Trav. La Crucca n. 3 - Reg. Baldinca, Sassari, 07100, Italy., Psaty BM; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, 1730 Minor Ave, Suite 1360, Seattle, 98101, WA, USA.; Group Health Research Institute, Group Health Cooperative, 1730 Minor Ave, Suite 1360, Seattle, 98101, WA, USA., Weir DR; Institute for Social Research, University of Michigan, 426 Thompson Street, 48104, Ann Arbor, MI, USA., Laakso M; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, 70210, Finland., Gudnason V; Icelandic Heart Association, Holtasmari 1, 201, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland., Takahashi A; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan., Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, W2 1PG, UK.; Department of Cardiology, Ealing Hospital NHS Trust, Uxbridge Road, Southall, Middlesex, UB1 3HW, UK.; Imperial College Healthcare NHS Trust, Imperial College London, Praed Street, London, W2 1NY, UK., Kooner JS; Department of Cardiology, Ealing Hospital NHS Trust, Uxbridge Road, Southall, Middlesex, UB1 3HW, UK.; National Heart and Lung Institute, Imperial College London, Du Cane Road, London, W12 0NN, UK.; Imperial College Healthcare NHS Trust, Imperial College London, Praed Street, London, W2 1NY, UK., Strachan DP; Population Health Research Institute, St George's, University of London, Cranmer Terrace, London, SW17 0RE, UK., Campbell H; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Hirschhorn JN; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Cambridge, 02141, MA, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge Center 7, Cambridge, 02242, MA, USA.; Department of Genetics, Harvard Medical School, 25 Shattuck St, Boston, 02115, MA, USA., Perola M; Estonian Genome Center, University of Tartu, Riia 23b, 51010, Tartu, Estonia.; Unit of Public Health Genomics, National Institute for Health and Welfare, P.O. Box 104, Helsinki, FI-00251, Finland., Polašek O; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.; Centre for Global Health and Department of Public Health, School of Medicine, University of Split, Soltanska 2, 21000 Split, Croatia., Wilson JF; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, EH4 2XU, Edinburgh, UK.
Publikováno v:
Nature [Nature] 2015 Jul 23; Vol. 523 (7561), pp. 459-462. Date of Electronic Publication: 2015 Jul 01.
Autor:
Chauhan G; INSERM U897, University of Bordeaux, Bordeaux, France; University of Bordeaux, Bordeaux, FranceINSERM U897, University of Bordeaux, Bordeaux, France., Adams HHH; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands; Department of Radiology, Erasmus Medical Center, Rotterdam, the Netherlands., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Weinstein G; Department of Neurology, Boston University School of Medicine, Boston, MA, USA; The Framingham Heart Study, Boston, MA, USA., Yu L; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., Töglhofer AM; Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Graz, Austria., Smith AV; Icelandic Heart Association, Iceland; Department of Medicine, University of Iceland, Reykjavik, Iceland., van der Lee SJ; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Gottesman RF; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, USA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA., Thomson R; Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia., Wang J; The Framingham Heart Study, Boston, MA, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Yang Q; The Framingham Heart Study, Boston, MA, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Niessen WJ; Department of Radiology, Erasmus Medical Center, Rotterdam, the Netherlands., Lopez OL; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Becker JT; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Phan TG; Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne, Victoria, Australia., Beare RJ; Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne, Victoria, Australia; Developmental Imaging Group, Murdoch Childrens Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia., Arfanakis K; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA., Fleischman D; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Vernooij MW; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands; Department of Radiology, Erasmus Medical Center, Rotterdam, the Netherlands., Mazoyer B; Groupe d'Imagerie Neurofonctionnelle, UMR5296, CNRS, CEA, Université de Bordeaux, Bordeaux, France., Schmidt H; Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Graz, Austria., Srikanth V; Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne, Victoria, Australia; Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia., Knopman DS; Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA., Jack CR Jr; Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN, USA., Amouyel P; Department of Epidemiology and Public Health, Pasteur Institute of Lille, Lille, France; INSERM, U744, Lille, France; Université Lille 2, Lille, France., Hofman A; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., DeCarli C; Department of Neurology, University of California at Davis, Davis, CA, USA., Tzourio C; INSERM U897, University of Bordeaux, Bordeaux, France., van Duijn CM; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands; Netherlands Consortium for Healthy Aging, Leiden, the Netherlands; Center for Medical Systems Biology, Leiden, the Netherlands., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., Schmidt R; Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria., Longstreth WT Jr; Departments of Neurology and Epidemiology, University of Washington, Seattle, WA, USA., Mosley TH; Department of Medicine-Geriatrics/Gerontology, University of Mississippi Medical Center, Jackson, MS, USA., Fornage M; The Human Genetics Center and Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, USA., Launer LJ; Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Seshadri S; Department of Neurology, Boston University School of Medicine, Boston, MA, USA; The Framingham Heart Study, Boston, MA, USA., Ikram MA; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands; Department of Radiology, Erasmus Medical Center, Rotterdam, the Netherlands; Netherlands Consortium for Healthy Aging, Leiden, the Netherlands., Debette S; INSERM U897, University of Bordeaux, Bordeaux, France; University of Bordeaux, Bordeaux, FranceINSERM U897, University of Bordeaux, Bordeaux, France; Department of Neurology, Boston University School of Medicine, Boston, MA, USA; Department of Neurology, Bordeaux University Hospital, Bordeaux, France. Electronic address: sdebette@bu.edu.
Publikováno v:
Neurobiology of aging [Neurobiol Aging] 2015 Apr; Vol. 36 (4), pp. 1765.e7-1765.e16. Date of Electronic Publication: 2015 Jan 06.
Autor:
Verhaaren BF, Debette S, Bis JC, Smith JA, Ikram MK, Adams HH, Beecham AH, Rajan KB, Lopez LM, Barral S, van Buchem MA, van der Grond J, Smith AV, Hegenscheid K, Aggarwal NT, de Andrade M, Atkinson EJ, Beekman M, Beiser AS, Blanton SH, Boerwinkle E, Brickman AM, Bryan RN, Chauhan G, Chen CP, Chouraki V, de Craen AJ, Crivello F, Deary IJ, Deelen J, De Jager PL, Dufouil C, Elkind MS, Evans DA, Freudenberger P, Gottesman RF, Guðnason V, Habes M, Heckbert SR, Heiss G, Hilal S, Hofer E, Hofman A, Ibrahim-Verbaas CA, Knopman DS, Lewis CE, Liao J, Liewald DC, Luciano M, van der Lugt A, Martinez OO, Mayeux R, Mazoyer B, Nalls M, Nauck M, Niessen WJ, Oostra BA, Psaty BM, Rice KM, Rotter JI, von Sarnowski B, Schmidt H, Schreiner PJ, Schuur M, Sidney SS, Sigurdsson S, Slagboom PE, Stott DJ, van Swieten JC, Teumer A, Töglhofer AM, Traylor M, Trompet S, Turner ST, Tzourio C, Uh HW, Uitterlinden AG, Vernooij MW, Wang JJ, Wong TY, Wardlaw JM, Windham BG, Wittfeld K, Wolf C, Wright CB, Yang Q, Zhao W, Zijdenbos A, Jukema JW, Sacco RL, Kardia SL, Amouyel P, Mosley TH, Longstreth WT Jr, DeCarli CC, van Duijn CM, Schmidt R, Launer LJ, Grabe HJ, Seshadri SS, Ikram MA, Fornage M
Publikováno v:
Circulation. Cardiovascular genetics [Circ Cardiovasc Genet] 2015 Apr; Vol. 8 (2), pp. 398-409. Date of Electronic Publication: 2015 Feb 07.