Gymnotic uptake of AntimiRs alter microRNA-34a levels in 2D and 3D epithelial cell culture.

Autor: Weidner J; Translational Science Experimental Medicine, Research & Early Development, Respiratory & Immunology, BioPharmaceutical R&D, AstraZeneca, 431 83 Mölndal, Sweden., Kolosionek E; Bioscience COPD/IPF, Research & Early Development, Respiratory & Immunology, BioPharmaceutical R&D, AstraZeneca, 431 83 Mölndal, Sweden., Holmila R; Bioscience COPD/IPF, Research & Early Development, Respiratory & Immunology, BioPharmaceutical R&D, AstraZeneca, 431 83 Mölndal, Sweden., Ax E; Translational Science Experimental Medicine, Research & Early Development, Respiratory & Immunology, BioPharmaceutical R&D, AstraZeneca, 431 83 Mölndal, Sweden., Garreau M; Medicinal Chemistry, Research & Early Development, Respiratory & Immunology, BioPharmaceutical R&D, AstraZeneca, 431 83 Mölndal, Sweden., Gnerlich F; Medicinal Chemistry, Research & Early Development, Respiratory & Immunology, BioPharmaceutical R&D, AstraZeneca, 431 83 Mölndal, Sweden., Olsson H; Translational Science Experimental Medicine, Research & Early Development, Respiratory & Immunology, BioPharmaceutical R&D, AstraZeneca, 431 83 Mölndal, Sweden., Czechtizky W; Medicinal Chemistry, Research & Early Development, Respiratory & Immunology, BioPharmaceutical R&D, AstraZeneca, 431 83 Mölndal, Sweden., Vollmer S; Bioscience COPD/IPF, Research & Early Development, Respiratory & Immunology, BioPharmaceutical R&D, AstraZeneca, 431 83 Mölndal, Sweden., Rydzik AM; Medicinal Chemistry, Research & Early Development, Respiratory & Immunology, BioPharmaceutical R&D, AstraZeneca, 431 83 Mölndal, Sweden.

Publikováno v: Molecular therapy. Nucleic acids [Mol Ther Nucleic Acids] 2023 Aug 18; Vol. 33, pp. 898-907. Date of Electronic Publication: 2023 Aug 18 (Print Publication: 2023).

Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors.

Autor: Brem J; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK. jurgen.brem@chem.ox.ac.uk., Panduwawala T; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Hansen JU; Statens Serum Institut, Copenhagen, Denmark., Hewitt J; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK., Liepins E; Latvian Institute of Organic Synthesis, Riga, Latvia., Donets P; Latvian Institute of Organic Synthesis, Riga, Latvia., Espina L; Department of Medical Microbiology, Institute of infection & Immunity, Cardiff University, Cardiff, UK., Farley AJM; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Shubin K; Latvian Institute of Organic Synthesis, Riga, Latvia., Campillos GG; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Kiuru P; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland., Shishodia S; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK.; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA., Krahn D; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Leśniak RK; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Schmidt Adrian J; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Calvopiña K; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Turrientes MC; Department of Microbiology, Ramón y Cajal University Hospital and Ramón y Cajal Institute for Health Research (IRYCIS), Madrid, Spain., Kavanagh ME; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK.; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Lubriks D; Latvian Institute of Organic Synthesis, Riga, Latvia., Hinchliffe P; School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK., Langley GW; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK.; Charles River Laboratories, Saffron Walden, UK., Aboklaish AF; Department of Medical Microbiology, Institute of infection & Immunity, Cardiff University, Cardiff, UK., Eneroth A; Department of Pharmacy, Uppsala Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), Uppsala University, Uppsala, Sweden., Backlund M; Department of Pharmacy, Uppsala Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), Uppsala University, Uppsala, Sweden., Baran AG; Latvian Institute of Organic Synthesis, Riga, Latvia., Nielsen EI; Department of Pharmacy, Uppsala University, Uppsala, Sweden., Speake M; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK.; BioAscent Discovery Ltd, Newhouse, UK., Kuka J; Latvian Institute of Organic Synthesis, Riga, Latvia., Robinson J; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK.; BioAscent Discovery Ltd, Newhouse, UK., Grinberga S; Latvian Institute of Organic Synthesis, Riga, Latvia., Robinson L; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK.; BioAscent Discovery Ltd, Newhouse, UK., McDonough MA; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Rydzik AM; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK.; Research and Early Development, Respiratory & Immunology, AstraZeneca, Mölndal, Sweden., Leissing TM; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Jimenez-Castellanos JC; School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.; Chemical Biology of Antibiotics, Centre for Infection & Immunity (CIIL), Pasteur Institute, INSERM U1019 - CNRS UMR 9017, Lille, France., Avison MB; School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK., Da Silva Pinto S; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Pannifer AD; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK., Martjuga M; Latvian Institute of Organic Synthesis, Riga, Latvia., Widlake E; Department of Medical Microbiology, Institute of infection & Immunity, Cardiff University, Cardiff, UK., Priede M; Latvian Institute of Organic Synthesis, Riga, Latvia., Hopkins Navratilova I; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK., Gniadkowski M; Department of Molecular Microbiology, National Medicines Institute, Warsaw, Poland., Belfrage AK; Department of Medicinal Chemistry, Drug Design and Discovery, Uppsala University, Uppsala, Sweden., Brandt P; Department of Medicinal Chemistry, Drug Design and Discovery, Uppsala University, Uppsala, Sweden.; Beactica Therapeutics AB, Uppsala, Sweden., Yli-Kauhaluoma J; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland., Bacque E; Evotec Infectious Diseases Lyon, Marcy l'Etoile, France., Page MGP; Jacobs University Bremen gGmbH, Bremen, Germany., Björkling F; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Tyrrell JM; Department of Medical Microbiology, Institute of infection & Immunity, Cardiff University, Cardiff, UK.; School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK., Spencer J; School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK., Lang PA; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Baranczewski P; Department of Pharmacy, SciLifeLab Drug Discovery and Development Platform, ADME of Therapeutics Facility, Uppsala University, Uppsala, Sweden., Cantón R; Department of Microbiology, Ramón y Cajal University Hospital and Ramón y Cajal Institute for Health Research (IRYCIS), Madrid, Spain., McElroy SP; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK.; BioAscent Discovery Ltd, Newhouse, UK., Jones PS; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK.; BioAscent Discovery Ltd, Newhouse, UK., Baquero F; Department of Microbiology, Ramón y Cajal University Hospital and Ramón y Cajal Institute for Health Research (IRYCIS), Madrid, Spain., Suna E; Latvian Institute of Organic Synthesis, Riga, Latvia., Morrison A; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK.; BioAscent Discovery Ltd, Newhouse, UK., Walsh TR; Department of Medical Microbiology, Institute of infection & Immunity, Cardiff University, Cardiff, UK., Schofield CJ; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK. christopher.schofield@chem.ox.ac.uk.

Publikováno v: Nature chemistry [Nat Chem] 2022 Jan; Vol. 14 (1), pp. 15-24. Date of Electronic Publication: 2021 Dec 13.

Epigenetic Modification 6-Methyladenosine Can Impact the Potency and Specificity of siRNA.

Autor: Rydzik AM; Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Strasse 65, 88397, Biberach an der Riss, Germany.; Current address: Research and Early Development, Respiratory & Immunology, AstraZeneca, 431 83, Mölndal, Sweden., Gottschling D; Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Strasse 65, 88397, Biberach an der Riss, Germany., Simon E; Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Strasse 65, 88397, Biberach an der Riss, Germany., Skronska-Wasek W; Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Strasse 65, 88397, Biberach an der Riss, Germany., Rippmann JF; Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Strasse 65, 88397, Biberach an der Riss, Germany., Riether D; Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Strasse 65, 88397, Biberach an der Riss, Germany.

Publikováno v: Chembiochem : a European journal of chemical biology [Chembiochem] 2021 Feb 02; Vol. 22 (3), pp. 491-495. Date of Electronic Publication: 2020 Oct 23.

¹⁹ F NMR studies on γ-butyrobetaine hydroxylase provide mechanistic insights and suggest a dual inhibition mode.

Autor: Leśniak RK; The Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK. tim.claridge@chem.ox.ac.uk christopher.schofield@chem.ox.ac.uk., Rydzik AM, Kamps JJAG, Kahn A, Claridge TDW, Schofield CJ

Publikováno v: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2019 Dec 05; Vol. 55 (98), pp. 14717-14720.

mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation.

Autor: Rydzik AM; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, Zwirki i Wigury 93, 02-089 Warsaw, Poland.; Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK., Warminski M; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, Zwirki i Wigury 93, 02-089 Warsaw, Poland., Sikorski PJ; Centre of New Technologies, University of Warsaw, Banacha 2c, 02-097 Warsaw, Poland., Baranowski MR; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, Zwirki i Wigury 93, 02-089 Warsaw, Poland., Walczak S; Centre of New Technologies, University of Warsaw, Banacha 2c, 02-097 Warsaw, Poland.; College of Inter-Faculty Individual Studies in Mathematics and Natural Sciences, University of Warsaw, Zwirki i Wigury 93, 02-089 Warsaw, Poland., Kowalska J; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, Zwirki i Wigury 93, 02-089 Warsaw, Poland., Zuberek J; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, Zwirki i Wigury 93, 02-089 Warsaw, Poland., Lukaszewicz M; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, Zwirki i Wigury 93, 02-089 Warsaw, Poland., Nowak E; Laboratory of Protein Structure, International Institute of Molecular and Cell Biology, 4 Ksiecia Trojdena Street, 02-109 Warsaw, Poland., W Claridge TD; Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK., Darzynkiewicz E; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, Zwirki i Wigury 93, 02-089 Warsaw, Poland.; Centre of New Technologies, University of Warsaw, Banacha 2c, 02-097 Warsaw, Poland., Nowotny M; Laboratory of Protein Structure, International Institute of Molecular and Cell Biology, 4 Ksiecia Trojdena Street, 02-109 Warsaw, Poland., Jemielity J; Centre of New Technologies, University of Warsaw, Banacha 2c, 02-097 Warsaw, Poland.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2017 Sep 06; Vol. 45 (15), pp. 8661-8675.