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A multivalent mRNA-LNP vaccine protects against Clostridioides difficile infection.

Autor: Alameh MG; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Semon A; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Bayard NU; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Pan YG; Division of Infectious Disease, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Dwivedi G; Division of Infectious Disease, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Knox J; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Glover RC; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Rangel PC; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Tanes C; Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Bittinger K; Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; The Center for Microbial Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA., She Q; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA., Hu H; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA., Bonam SR; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA., Maslanka JR; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Planet PJ; The Center for Microbial Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Pediatric Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Comparative Genomics, American Museum of Natural History, New York, NY, USA., Moustafa AM; Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; The Center for Microbial Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Davis B; Division of Infectious Disease, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Chevrier A; Chemical Engineering Department, Polytechnique Montreal, Montreal, QC, Canada., Beattie M; Acuitas Therapeutics, Vancouver, British Columbia, Canada., Ni H; Acuitas Therapeutics, Vancouver, British Columbia, Canada., Blizard G; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Furth EE; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Mach RH; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lavertu M; Chemical Engineering Department, Polytechnique Montreal, Montreal, QC, Canada., Sellmyer MA; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Tam Y; Acuitas Therapeutics, Vancouver, British Columbia, Canada., Abt MC; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Weissman D; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Division of Infectious Disease, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Zackular JP; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; The Center for Microbial Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2024 Oct 04; Vol. 386 (6717), pp. 69-75. Date of Electronic Publication: 2024 Oct 03.

A two-variant model of SARS-COV-2 transmission: estimating the characteristics of a newly emerging strain.

Autor: Yamana TK; Columbia University, New York, NY, USA. tky2104@cumc.columbia.edu., Rajagopal S; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Hall DC Jr; Drexel University, Philadelphia, PA, USA., Moustafa AM; Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Feder A; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Ahmed A; Drexel University, Philadelphia, PA, USA., Bianco C; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Harris R; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Coffin S; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Campbell AE; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Pei S; Columbia University, New York, NY, USA., Mell JC; Drexel University, Philadelphia, PA, USA., Planet PJ; Children's Hospital of Philadelphia, Philadelphia, PA, USA. planetp@chop.edu.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. planetp@chop.edu., Shaman J; Columbia University, New York, NY, USA.

Publikováno v: BMC infectious diseases [BMC Infect Dis] 2024 Sep 09; Vol. 24 (1), pp. 938. Date of Electronic Publication: 2024 Sep 09.

Liberation of host heme by Clostridioides difficile- mediated damage enhances Enterococcus faecalis fitness during infection.

Autor: Smith AB; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Specker JT; Department of Chemistry, University of Florida, Gainesville, Florida, USA., Hewlett KK; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Scoggins TR 4th; Department of Chemistry, University of Florida, Gainesville, Florida, USA., Knight M; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Lustig AM; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Li Y; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Tsinghua University School of Medicine, Beijing, China., Evans KM; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Guo Y; Department of Chemistry, University of Florida, Gainesville, Florida, USA., She Q; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Christopher MW; Department of Chemistry, University of Florida, Gainesville, Florida, USA., Garrett TJ; Department of Chemistry, University of Florida, Gainesville, Florida, USA.; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, Florida, USA., Moustafa AM; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Van Tyne D; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Prentice BM; Department of Chemistry, University of Florida, Gainesville, Florida, USA., Zackular JP; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Publikováno v: MBio [mBio] 2024 Jan 16; Vol. 15 (1), pp. e0165623. Date of Electronic Publication: 2023 Dec 11.

Transcription Factor 23 is an Essential Determinant of Murine Term Parturition.

Autor: Minisy FM; Department of Comparative and Experimental Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.; Department of Pathology, National Research Centre, Cairo, Egypt., Shawki HH; Department of Comparative and Experimental Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.; Department of Animal Genetic Resources, National Gene Bank of Egypt, ARC, Giza, Egypt., Fujita T; Department of Comparative and Experimental Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan., Moustafa AM; Department of Comparative and Experimental Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan., Sener R; Department of Comparative and Experimental Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan., Nishio Y; Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan., Shimada IS; Department of Cell Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan., Saitoh S; Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan., Sugiura-Ogasawara M; Department of Obstetrics and Gynecology, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan., Oishi H; Department of Comparative and Experimental Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

Publikováno v: Molecular and cellular biology [Mol Cell Biol] 2024; Vol. 44 (8), pp. 316-333. Date of Electronic Publication: 2024 Jul 16.