Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Am, Ibrado"'
Publikováno v:
Europe PubMed Central
Paclitaxel has been shown to activate Raf-1 and cause phosphorylation of Bcl-2, which has been correlated with paclitaxel-induced apoptosis of cancer cells. In the present studies, we demonstrate that in human AML HL-60 cells that express Bcl-2 but l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b0ccb42c5eb3bc88b16943bcc481b7c9
https://pubmed.ncbi.nlm.nih.gov/9067280
https://pubmed.ncbi.nlm.nih.gov/9067280
Publikováno v:
Europe PubMed Central
Human chronic myelogenous leukemia-blast crisis K562 cells have been demonstrated to be relatively resistant to antileukemic drug-induced apoptosis. This has been attributed to the activity of p210bcr-abl tyrosine kinase present in the K562 cells, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::82fd949c1f0882ac0b61ac5d0ca73d87
https://pubmed.ncbi.nlm.nih.gov/8959329
https://pubmed.ncbi.nlm.nih.gov/8959329
Publikováno v:
Europe PubMed Central
We examined the effects of high intracellular levels of Bcl-2 on the metabolism and DNA incorporation of high-dose Ara-C (HIDAC) as well as on Ara-C-induced DNA strand breaks and apoptosis of human AML HL-60 cells. HL-60/Bcl-2 and HL-60/neo cells wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::82c6cb4f593bdc1c3aee7ea85828169d
https://pubmed.ncbi.nlm.nih.gov/8892676
https://pubmed.ncbi.nlm.nih.gov/8892676
Publikováno v:
Europe PubMed Central
Ara-C has been shown to induce apoptosis of human acute myelogenous leukemia HL-60 cells. The DNA repair enzyme poly(ADP-ribose) polymerase (PARP) is known to be degraded during apoptosis. PARP as a substrate is cleaved by the Yama protease, encoded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::07dcbcc626fa89db868db1031d96b9ab
https://pubmed.ncbi.nlm.nih.gov/8840993
https://pubmed.ncbi.nlm.nih.gov/8840993
Autor:
Ponnathpur V, Am, Ibrado, Jc, Reed, Ray S, Huang Y, Self S, Bullock G, Nawabi A, Kapil Bhalla
Publikováno v:
Europe PubMed Central
Taxol-induced polymerization of tubulin into stable microtubules and cell cycle metaphase arrest have been demonstrated to result in internucleosomal DNA fragmentation and morphological features of apoptosis in human leukemia cells. Recent studies ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d2e77d092790f89f404c4be62400cfd6
https://pubmed.ncbi.nlm.nih.gov/9815937
https://pubmed.ncbi.nlm.nih.gov/9815937
Autor:
Kapil Bhalla, Huang Y, Tang C, Self S, Ray S, Me, Mahoney, Ponnathpur V, Tourkina E, Am, Ibrado, Bullock G
Publikováno v:
Europe PubMed Central
Taxol-resistant sublines of HL-60 myeloid leukemia cells (HL-60/TAX100 and HL-60/TAX1000) have been isolated in vitro by subculturing in progressively higher concentrations of taxol. HL-60/TAX100 and HL-60/TAX1000 cells are capable of continuous grow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6df2766d7fd5a943b049b8b317b2b2fd
https://pubmed.ncbi.nlm.nih.gov/7907395
https://pubmed.ncbi.nlm.nih.gov/7907395
Publikováno v:
Europe PubMed Central
4-Hydroperoxycyclophosphamide (4-HC) is widely used as an ex vivo bone marrow purging agent for acute myeloid leukemia (AML) blasts. We have determined the effect of a combined treatment with interleukin 3 (IL-3) plus IL-6 on 4-HC cytotoxicity agains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::084eb59cf40feed2c0d8788c1c629506
https://pubmed.ncbi.nlm.nih.gov/1640734
https://pubmed.ncbi.nlm.nih.gov/1640734
Publikováno v:
Europe PubMed Central
Hematopoietic growth factors (HGFs) interleukin-3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF) individually have been shown to increase the percentage of acute myeloid leukemia (AML) blasts in S phase and enhance the cytotoxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::fe6ed4e6a1c61ae75f19ce463554bf48
https://pubmed.ncbi.nlm.nih.gov/1824260
https://pubmed.ncbi.nlm.nih.gov/1824260
Autor:
Kapil Bhalla, Gn, Kumar, Uk, Walle, Am, Ibrado, Javed T, Rk, Stuart, Reed C, Sg, Arbuck, Walle T
Publikováno v:
Europe PubMed Central
A Phase I and pharmacological study of paclitaxel administered as an outpatient, 3-h i.v. infusion just before a 5-day regimen of daily cisplatinum (CP) and a continuous infusion of 5-fluorouracil (5-FU) was performed in patients with advanced solid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c5668a67bfef18ab81fcca2df020f86b
http://europepmc.org/abstract/med/10430075
http://europepmc.org/abstract/med/10430075
Publikováno v:
Europe PubMed Central
The present results demonstrate that the exposure of human myeloid leukemia HL-60 and KG-1 cells to clinically achievable concentrations of taxol produced internucleosomal DNA fragmentation of approximately 200 base-pair multiples, and the morphologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a6665c4c7c346d2937c86d6aa5189415
http://europepmc.org/abstract/med/8096557
http://europepmc.org/abstract/med/8096557