Zobrazeno 1 - 10
of 536
pro vyhledávání: '"Alzir A, Batista"'
Autor:
Larissa M. Bomfim, Sara P. Neves, Amanda M. R. M. Coelho, Mateus L. Nogueira, Rosane B. Dias, Ludmila de F. Valverde, Clarissa A. G. Rocha, Milena B. P. Soares, Alzir A. Batista, Rodrigo S. Correa, Daniel P. Bezerra
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract Cancer stem cells (CSCs) are defined as a rare population of cancer cells related to tumor initiation and maintenance. These cells are primarily responsible for tumor growth, invasion, metastasis, recurrence, and resistance to chemotherapy.
Externí odkaz:
https://doaj.org/article/63a439c6ac1e4c5aab3ab93b75fd2589
Autor:
Sara P. Neves, Larissa M. Bomfim, Tetsushi Kataura, Sabrine G. Carvalho, Mateus L. Nogueira, Rosane B. Dias, Ludmila de F. Valverde, Clarissa A. Gurgel Rocha, Milena B.P. Soares, Monize M. da Silva, Alzir A. Batista, Viktor I. Korolchuk, Daniel P. Bezerra
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 117059- (2024)
Hepatic cancer is one of the main causes of cancer-related death worldwide. Cancer stem cells (CSCs) are a unique subset of cancer cells that promote tumour growth, maintenance, and therapeutic resistance, leading to recurrence. In the present work,
Externí odkaz:
https://doaj.org/article/5de2c0ecc9a040099690f48ea204e249
Autor:
Flávia E. Jacinto, Letícia Pires de Oliveira, Alzir A. Batista, Katia M. Oliveira, Rodrigo S. Correa
Publikováno v:
Royal Society Open Science, Vol 11, Iss 7 (2024)
Ruthenium(II) complexes (Ru1–Ru3) with the general formula [Ru(O-O)(PPh3)2(bipy)]PF6, bearing two triphenylphosphine (PPh3), bipyridine (bipy) and a series of natural and synthetic β-diketones (O,O) ligands were synthesized and characterized using
Externí odkaz:
https://doaj.org/article/67187792e95546b288b381ed100b1ba3
Autor:
Valdenizia R. Silva, Luciano de S. Santos, Maria V. L. de Castro, Rosane B. Dias, Ludmila de F. Valverde, Clarissa A. G. Rocha, Milena B. P. Soares, Claudio A. Quadros, Rodrigo S. Correa, Alzir A. Batista, Daniel P. Bezerra
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-13 (2023)
Abstract [Ru(5-FU)(PPh3)2(bipy)]PF6 (Ru/5-FU) is a novel ruthenium complex with 5-fluorouracil with promising potential against colorectal cancer (CRC). In the present study, we investigated the molecular mechanism of Ru/5-FU action in HCT116 CRC cel
Externí odkaz:
https://doaj.org/article/55b2ba52b0974d398bd5bd355686c8dc
Autor:
Marianna C. Silva, Gracielle Cunha, Pollyana Firmino, Loide O. Sallum, Antônio Menezes, Jocely Dutra, João de Araujo-Neto, Alzir A. Batista, Javier Ellena, Hamilton B. Napolitano
Publikováno v:
ACS Omega, Vol 8, Iss 43, Pp 40764-40774 (2023)
Externí odkaz:
https://doaj.org/article/25a05d9bd0c949a2a2e117cb92b5cf61
Autor:
Jhon Rewllyson Torres dos Reis, Fabio Furtado Leite, Keshav Sharma, Guilherme Almeida Silva Ribeiro, Welesson Henrique Natanael Silva, Alzir Azevedo Batista, Alexandre Rocha Paschoal, Waldeci Paraguassu, Mario Mazzoni, Newton Martins Barbosa Neto, Paulo Trindade Araujo
Publikováno v:
Molecules, Vol 29, Iss 10, p 2362 (2024)
We present a Raman spectroscopy study of the vibrational properties of free-base meso-tetra(4-pyridyl) porphyrin polycrystals under various temperature and hydrostatic pressure conditions. The combination of experimental results and Density Functiona
Externí odkaz:
https://doaj.org/article/8908037a9f26485b98f6be85849755e5
Autor:
Carlos Y. Fernández, Analu Rocha, Mohammad Azam, Natalia Alvarez, Kim Min, Alzir A. Batista, Antonio J. Costa-Filho, Javier Ellena, Gianella Facchin
Publikováno v:
Inorganics, Vol 11, Iss 10, p 398 (2023)
Coordination compounds of copper exhibit cytotoxic activity and are suitable for the search for novel drug candidates for cancer treatment. In this work, we synthesized three copper(II) carboxylate complexes, [Cu2(3-(4-hydroxyphenyl)propanoate)4(H2O)
Externí odkaz:
https://doaj.org/article/a33e4b5eeecd410193bad9a54b3f2520
Autor:
Celisnolia M. Leite, João H. Araujo-Neto, Adriana P. M. Guedes, Analu R. Costa, Felipe C. Demidoff, Chaquip D. Netto, Eduardo E. Castellano, Otaciro R. Nascimento, Alzir A. Batista
Publikováno v:
Inorganics, Vol 11, Iss 9, p 367 (2023)
Four new Cu/PPh3/naphtoquinone complexes were synthesized, characterized (IR, UV/visible, 1D/2D NMR, mass spectrometry, elemental analysis, and X-ray diffraction), and evaluated as anticancer agents. We also investigated the reactive oxygen species (
Externí odkaz:
https://doaj.org/article/9a7ae2472278465a961451e203b155a4
Autor:
Marília I. F. Barbosa, Rodrigo S. Corrêa, Adriana P. M. Guedes, Alex M. Graça, Francyelli M. Andrade, Celisnólia M. Leite, Elisângela P. Silveira-Lacerda, Javier Ellena, Henrique V. Reis, Antônio C. Doriguetto, Alzir A. Batista
Publikováno v:
Inorganics, Vol 11, Iss 7, p 270 (2023)
Herein, we report on the synthesis and characterization of ruthenium compounds with the general formula [RuCl(AA-H)(NO)(dppb]PF6, where AA = glycine (1), L-alanine (2), L-phenylalanine (3) and L-valine (4), and dppb = 1,4-bis(diphenylphosphine)butane
Externí odkaz:
https://doaj.org/article/eda0d5c9c3c54050ad35bae33210450a
Autor:
Natalia Alvarez, Analu Rocha, Victoria Collazo, Javier Ellena, Antonio J. Costa-Filho, Alzir A. Batista, Gianella Facchin
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1345 (2023)
Coordination complexes may act as anticancer agents. Among others, the formation of the complex may facilitate the ligand uptake by the cell. Searching for new copper compounds with cytotoxic activity, the complex Cu-dipicolinate was studied as a neu
Externí odkaz:
https://doaj.org/article/a76adc44a34744b0a3bc66ec74b82e55