Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Alzheimer Disease/pathology"'
Autor:
Miho Uematsu, Ayako Nakamura, Momoko Ebashi, Katsuiku Hirokawa, Ryosuke Takahashi, Toshiki Uchihara
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-18 (2018)
Abstract Introduction Alzheimer-type neuropil threads (NTs) and neurofibrillary tangles (NFTs) are comprised of either 4 repeat (4R)-tau, 3 repeat (3R)-tau, or a mixture of both. In the hippocampus, the number of NFTs, and the proportion of 3R tau pr
Externí odkaz:
https://doaj.org/article/78f65aa95634471c87d623dcaba91ce0
Autor:
Merel O. Mol, Suzanne S. M. Miedema, Shamiram Melhem, Ka Wan Li, Frank Koopmans, Harro Seelaar, Kurt Gottmann, Volkmar Lessmann, Netherlands Brain Bank, August B. Smit, John C. van Swieten, Jeroen G. J. van Rooij
Publikováno v:
Acta neuropathologica communications, 10(1). BioMed Central
Acta neuropathologica communications, 10(1):190. BioMed Central Ltd.
Acta Neuropathologica Communications, 10:190, 1-14. BioMed Central
Mol, M O, Miedema, S S M, Melhem, S, Li, K W, Koopmans, F, Seelaar, H, Gottmann, K, Lessmann, V, Bank, N B, Smit, A B, van Swieten, J C & van Rooij, J G J 2022, ' Proteomics of the dentate gyrus reveals semantic dementia specific molecular pathology ', Acta Neuropathologica Communications, vol. 10, 190, pp. 1-14 . https://doi.org/10.1186/s40478-022-01499-1
Acta neuropathologica communications, 10(1):190. BioMed Central Ltd.
Acta Neuropathologica Communications, 10:190, 1-14. BioMed Central
Mol, M O, Miedema, S S M, Melhem, S, Li, K W, Koopmans, F, Seelaar, H, Gottmann, K, Lessmann, V, Bank, N B, Smit, A B, van Swieten, J C & van Rooij, J G J 2022, ' Proteomics of the dentate gyrus reveals semantic dementia specific molecular pathology ', Acta Neuropathologica Communications, vol. 10, 190, pp. 1-14 . https://doi.org/10.1186/s40478-022-01499-1
Semantic dementia (SD) is a clinical subtype of frontotemporal dementia consistent with the neuropathological diagnosis frontotemporal lobar degeneration (FTLD) TDP type C, with characteristic round TDP-43 protein inclusions in the dentate gyrus. Des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed0b363e7599f2897ec7ab336303ed96
https://doi.org/10.1186/s40478-022-01499-1
https://doi.org/10.1186/s40478-022-01499-1
Publikováno v:
Dias, I H K, Shokr, H, Shephard, F & Chakrabarti, L 2022, ' Oxysterols and Oxysterol Sulfates in Alzheimer's Disease Brain and Cerebrospinal Fluid ', Journal of Alzheimer's disease : JAD, vol. 87, no. 4, pp. 1527-1536 . https://doi.org/10.3233/JAD-220083
Dias, I HK, Shokr, H, Shephard, F & Chakrabarti, L 2022, ' Oxysterols and Oxysterol Sulfates in Alzheimer’s Disease Brain and Cerebrospinal Fluid ', Journal of Alzheimer's Disease, no. Preprint, pp. 1-10 . https://doi.org/10.3233/JAD-220083
Dias, I HK, Shokr, H, Shephard, F & Chakrabarti, L 2022, ' Oxysterols and Oxysterol Sulfates in Alzheimer’s Disease Brain and Cerebrospinal Fluid ', Journal of Alzheimer's Disease, no. Preprint, pp. 1-10 . https://doi.org/10.3233/JAD-220083
Background:Brain cholesterol levels are tightly regulated but increasing evidence indicates that cholesterol metabolism may drive Alzheimer’s disease (AD)-associated pathological changes. Recent advances in understanding of mitochondrial dysfunctio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::241ca37fd383567984e0620d5a4d8cd5
https://doi.org/10.3233/jad-220083
https://doi.org/10.3233/jad-220083
Autor:
Tian, Mei, Civelek, A. Cahid, Carrio, Ignasi, Watanabe, Yasuyoshi, Kang, Keon Wook, Murakami, Koji, Garibotto, Valentina, Prior, John O., Barthel, Henryk, Zhou, Rui, Hou, Haifeng, Dou, Xiaofeng, Jin, Chentao, Zuo, Chuantao, Zhang, Hong
Publikováno v:
European journal of nuclear medicine and molecular imaging, vol. 49, no. 3, pp. 895-904
European Journal of Nuclear Medicine and Molecular Imaging
European Journal of Nuclear Medicine and Molecular Imaging
Purpose Positron emission tomography (PET) with the first and only tau targeting radiotracer of 18F-flortaucipir approved by FDA has been increasingly used in depicting tau pathology deposition and distribution in patients with cognitive impairment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7ece70328abb1d445e9bd4089f64e7b
https://doi.org/10.1007/s00259-021-05673-w
https://doi.org/10.1007/s00259-021-05673-w
Autor:
Chi Him Poon, San Tung Nicholas Wong, Jaydeep Roy, Yingyi Wang, Hui Wang Hujo Chan, Harry Steinbusch, Arjan Blokland, Yasin Temel, Luca Aquili, Lee Wei Lim
Publikováno v:
Cells, 12(5):780. Multidisciplinary Digital Publishing Institute (MDPI)
Cells
Volume 12
Issue 5
Pages: 780
Cells
Volume 12
Issue 5
Pages: 780
A promising direction in the research on Alzheimer’s Disease (AD) is the identification of biomarkers that better inform the disease progression of AD. However, the performance of amyloid-based biomarkers in predicting cognitive performance has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3654ed3ff4a9f25c71ac4a3592539475
https://cris.maastrichtuniversity.nl/en/publications/8df688d5-62e6-480b-a54c-93ac1b53ac3c
https://cris.maastrichtuniversity.nl/en/publications/8df688d5-62e6-480b-a54c-93ac1b53ac3c
Autor:
Clementine Morisset, Alexandre Dizeux, Benoit Larrat, Erwan Selingue, Herve Boutin, Serge Picaud, Jose-Alain Sahel, Nathalie Ialy-Radio, Sophie Pezet, Mickael Tanter, Thomas Deffieux
Publikováno v:
Scientific Reports
Scientific Reports, 2022, 12, pp.19515. ⟨10.1038/s41598-022-23366-8⟩
Morisset, C, Dizeux, A, Larrat, B, Selingue, E, Boutin, H, Picaud, S, Sahel, J-A, Ialy-Radio, N, Pezet, S, Tanter, M & Deffieux, T 2022, ' Retinal functional ultrasound imaging (rfUS) for assessing neurovascular alterations : a pilot study on a rat model of dementia ', Scientific Reports, vol. 12, no. 1, 19515 . https://doi.org/10.1038/s41598-022-23366-8
Scientific Reports, 2022, 12, pp.19515. ⟨10.1038/s41598-022-23366-8⟩
Morisset, C, Dizeux, A, Larrat, B, Selingue, E, Boutin, H, Picaud, S, Sahel, J-A, Ialy-Radio, N, Pezet, S, Tanter, M & Deffieux, T 2022, ' Retinal functional ultrasound imaging (rfUS) for assessing neurovascular alterations : a pilot study on a rat model of dementia ', Scientific Reports, vol. 12, no. 1, 19515 . https://doi.org/10.1038/s41598-022-23366-8
Fifty million people worldwide are affected by dementia, a heterogeneous neurodegenerative condition encompassing diseases such as Alzheimer’s, vascular dementia, and Parkinson’s. For them, cognitive decline is often the first marker of the patho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc13d471db495d8d92d9de3baeeb9ae2
https://hal.science/hal-03912285
https://hal.science/hal-03912285
Autor:
Amalie Clement, Marianne Juul Madsen, Kenneth Kastaniegaard, Ove Wiborg, Ayodeji A. Asuni, Allan Stensballe
Publikováno v:
Clement, A, Madsen, M J, Kastaniegaard, K, Wiborg, O, Asuni, A A & Stensballe, A 2022, ' Chronic Stress Induces Hippocampal Mitochondrial Damage in APPPS1 Model Mice and Wildtype Littermates ', Journal of Alzheimer's Disease, vol. 87, no. 1, pp. 259-272 . https://doi.org/10.3233/JAD-220064
BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disorder and the most common cause of dementia worldwide. Despite decades of investigation, the etiology of AD is not fully understood, although emerging evidence suggest that chronic enviro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a03398ee56b31c5ecaab6ae16181b1
https://pubmed.ncbi.nlm.nih.gov/35275551
https://pubmed.ncbi.nlm.nih.gov/35275551
Autor:
Jan Homolak, Jelena Osmanovic Barilar, Melita Salkovic-Petrisic, Ana Babic Perhoc, Ana Knezovic
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 548
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 23, Iss 548, p 548 (2022)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 23, Iss 548, p 548 (2022)
SummaryThe incretin system is an emerging new field that might provide valuable contributions to the research of both pathophysiology and therapeutic strategies in the treatment of diabetes, obesity, and neurodegenerative disorders. This study aimed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecc3b745c1856fd0a853c582c768edd9
Publikováno v:
NeuroImage: Clinical, 33:102948. ELSEVIER SCI LTD
NeuroImage: Clinical, Vol 33, Iss, Pp 102948-(2022)
NeuroImage: Clinical, Vol 33, Iss, Pp 102948-(2022)
The recently described biological framework of Alzheimer's disease (AD) emphasizes three types of pathology to characterize this disorder, referred to as the 'amyloid/tau/neurodegeneration' (A-T-N) status. The 'neurodegenerative' component is typical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9624adc43be091244cca19051ebab732
https://doi.org/10.1016/j.nicl.2022.102948
https://doi.org/10.1016/j.nicl.2022.102948
Autor:
Leroux, Elodie, Perbet, Romain, Caillerez, Raphaëlle, Richetin, Kevin, Lieger, Sarah, Espourteille, Jeanne, Bouillet, Thomas, Bégard, Séverine, Danis, Clément, Loyens, Anne, Toni, Nicolas, Déglon, Nicole, Deramecourt, Vincent, Schraen-Maschke, Susanna, Buée, Luc, Colin, Morvane
Publikováno v:
Molecular Therapy
Molecular Therapy, 2021, pp.S1525-0016(21)00475-5. ⟨10.1016/j.ymthe.2021.09.020⟩
Molecular Therapy, vol. 30, no. 2, pp. 782-797
Molecular Therapy, Cell Press, 2021, pp.S1525-0016(21)00475-5. ⟨10.1016/j.ymthe.2021.09.020⟩
Molecular Therapy, 2021, pp.S1525-0016(21)00475-5. ⟨10.1016/j.ymthe.2021.09.020⟩
Molecular Therapy, vol. 30, no. 2, pp. 782-797
Molecular Therapy, Cell Press, 2021, pp.S1525-0016(21)00475-5. ⟨10.1016/j.ymthe.2021.09.020⟩
Tauopathies are neurodegenerative diseases characterized by tau inclusions in brain cells. Seed-competent tau species have been suggested to spread from cell to cell in a stereotypical manner, indicating that this may involve a prion-like mechanism.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0cf6496faeec34f02544fd301f7cdf92
https://www.hal.inserm.fr/inserm-03356237
https://www.hal.inserm.fr/inserm-03356237