Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Alzbeta Tuerkova"'
Autor:
Alzbeta Tuerkova, Ivo Kabelka, Tereza Králová, Lukáš Sukeník, Šárka Pokorná, Martin Hof, Robert Vácha
Publikováno v:
eLife, Vol 9 (2020)
Every cell is protected by a semipermeable membrane. Peptides with the right properties, for example Antimicrobial peptides (AMPs), can disrupt this protective barrier by formation of leaky pores. Unfortunately, matching peptide properties with their
Externí odkaz:
https://doaj.org/article/1d109efe403f427794d37ce9da3fc4ec
Autor:
Erzsébet Mernyák, Csilla Özvegy-Laczka, Gergely Szakács, Réka Laczkó-Rigó, Alzbeta Tuerkova, Barbara Zdrazil, Orsolya Ungvári
Publikováno v:
Journal of Chemical Information and Modeling
Hepatic organic anion transporting polypeptides-OATP1B1, OATP1B3, and OATP2B1-are expressed at the basolateral membrane of hepatocytes, being responsible for the uptake of a wide range of natural substrates and structurally unrelated pharmaceuticals.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a46d3fde1bfd2f8241886b46753b4dd3
https://doi.org/10.1021/acs.jcim.1c00362
https://doi.org/10.1021/acs.jcim.1c00362
Autor:
Alzbeta Tuerkova, Brandon J. Bongers, Ulf Norinder, Orsolya Ungvári, Virág Székely, Andrey Tarnovskiy, Gergely Szakács, Csilla Özvegy-Laczka, Gerard J. P. van Westen, Barbara Zdrazil
Publikováno v:
Journal of Chemical Information and Modeling, 62(24), 6323-6335
Integration of statistical learning methods with structure-based modeling approaches is a contemporary strategy to identify novel lead compounds in drug discovery. Hepatic organic anion transporting polypeptides (OATP1B1, OATP1B3, and OATP2B1) are cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2eeac7d5c1452f50a62f8a95e70c46c
https://hdl.handle.net/1887/3420604
https://hdl.handle.net/1887/3420604
Autor:
Tina Seitz, Barbara Zdrazil, Sarah Römer, Jürgen Brockmöller, Stefan Oswald, Christoph Wenzel, Jochen Gaedcke, Mladen V. Tzvetkov, Alzbeta Tuerkova, Marleen Julia Meyer
Publikováno v:
Drug Metabolism and Disposition. 48:1380-1392
The most commonly used oral antidiabetic drug, metformin, is a substrate of the hepatic uptake transporter OCT1 (gene name SLC22A1). However, OCT1 deficiency leads to more pronounced reductions of metformin concentrations in mouse than in human liver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de2f849b1f125a11656d2269d6826b5f
https://doi.org/10.1124/dmd.120.000170
https://doi.org/10.1124/dmd.120.000170
Autor:
Barbara Zdrazil, Alzbeta Tuerkova
Publikováno v:
Journal of Cheminformatics
Biomedical information mining is increasingly recognized as a promising technique to accelerate drug discovery and development. Especially, integrative approaches which mine data from several (open) data sources have become more attractive with the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c152269f0c96bbff0d725b12f4d27b50
http://europepmc.org/articles/PMC7686838
http://europepmc.org/articles/PMC7686838
Autor:
Alzbeta Tuerkova, Zdrazil, Barbara
Additional file 1. Supplementary Information—(1) a list of drug targets with potential interest for treatment of COVID-19, available from https://covid-19.uniprot.org/uniprotkb?query=* and (2) from the Open Targets Platform, (3) number of unique li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c797ac48d539c05a78723828070dcf
Autor:
Tereza Králová, Ivo Kabelka, Martin Hof, Šárka Pokorná, Robert Vácha, Lukáš Sukeník, Alzbeta Tuerkova
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Every cell is protected by a semipermeable membrane. Peptides with the right properties, e.g. Antimicrobial peptides (AMPs), can disrupt this protective barrier by formation of leaky pores. Unfortunately, matching peptide properties with their abilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd96b66750b782663f20d2cf12461a87
https://pubmed.ncbi.nlm.nih.gov/32167466
https://pubmed.ncbi.nlm.nih.gov/32167466