Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Alzbeta Hulikova"'
Autor:
Johanna Michl, Stefania Monterisi, Bobby White, Wiktoria Blaszczak, Alzbeta Hulikova, Gulnar Abdullayeva, Esther Bridges, Zinan Yin, Walter F. Bodmer, Pawel Swietach
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112601- (2023)
Summary: Acidic environments reduce the intracellular pH (pHi) of most cells to levels that are sub-optimal for growth and cellular functions. Yet, cancers maintain an alkaline cytoplasm despite low extracellular pH (pHe). Raised pHi is thought to be
Externí odkaz:
https://doaj.org/article/fa74c4cb09b5443a9fcec040cffeaf11
Autor:
Stefania Monterisi, Johanna Michl, Alzbeta Hulikova, Jana Koth, Esther M Bridges, Amaryllis E Hill, Gulnar Abdullayeva, Walter F Bodmer, Pawel Swietach
Publikováno v:
eLife, Vol 11 (2022)
Growth of cancer cells in vitro can be attenuated by genetically inactivating selected metabolic pathways. However, loss-of-function mutations in metabolic pathways are not negatively selected in human cancers, indicating that these genes are not ess
Externí odkaz:
https://doaj.org/article/6873e0339c734b01bab661f7fa921019
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35949 (2012)
Low extracellular pH (pH(e)), that is characteristic of many tumours, tends to reduce the uptake of weakly basic drugs, such as doxorubicin, thereby conferring a degree of physiological resistance to chemotherapy. It has been assumed, from pH-partiti
Externí odkaz:
https://doaj.org/article/dc37268d584641acb77f65c9b256d2b6
Autor:
Adrian L. Harris, Pawel Swietach, Angela Russell, Ji-Liang Li, Simon Wigfield, Esther Bridges, Dylan Jones, Peter Seden, Graham Steers, Dean Singleton, Cameron Snell, Ioanna Ledaki, Alzbeta Hulikova, Alan McIntyre
The expression of bicarbonate transporters in a panel of cell lines relative to the expression of β actin.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03410bfa532a526847222f6f05bf2268
https://doi.org/10.1158/0008-5472.22407776.v1
https://doi.org/10.1158/0008-5472.22407776.v1
Autor:
Jaromir Pastorek, Silvia Pastorekova, Claudiu T. Supuran, Juraj Kopacek, Lucia Csaderova, Miriam Zatovicova, Anna Ohradanova-Repic, Alzbeta Hulikova, Eliska Svastova, Franck Dequiedt, Peter Ditte
PDf file - 71K, List of primers used for cloning of phosphorylation mutants and CA IX-CA II and CA IX-CA XII chimeras. Boldcase sequences represent nucleotides aligning to CA IX part.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8b51bdfc5f064a8c19742835b77a69
https://doi.org/10.1158/0008-5472.22390062.v1
https://doi.org/10.1158/0008-5472.22390062.v1
Autor:
Jaromir Pastorek, Silvia Pastorekova, Claudiu T. Supuran, Juraj Kopacek, Lucia Csaderova, Miriam Zatovicova, Anna Ohradanova-Repic, Alzbeta Hulikova, Eliska Svastova, Franck Dequiedt, Peter Ditte
PDF file - 78K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::391161955ecbb062b3238e262254f0b9
https://doi.org/10.1158/0008-5472.22390065.v1
https://doi.org/10.1158/0008-5472.22390065.v1
Autor:
Adrian L. Harris, Pawel Swietach, Angela Russell, Ji-Liang Li, Simon Wigfield, Esther Bridges, Dylan Jones, Peter Seden, Graham Steers, Dean Singleton, Cameron Snell, Ioanna Ledaki, Alzbeta Hulikova, Alan McIntyre
Validation of HIF1α and HIF2α knockdown by quantitative-PCR in Ls174T.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c71aed5d69bb4a718a8968fbc10bd592
https://doi.org/10.1158/0008-5472.22407764.v1
https://doi.org/10.1158/0008-5472.22407764.v1
Autor:
Adrian L. Harris, Pawel Swietach, Angela Russell, Ji-Liang Li, Simon Wigfield, Esther Bridges, Dylan Jones, Peter Seden, Graham Steers, Dean Singleton, Cameron Snell, Ioanna Ledaki, Alzbeta Hulikova, Alan McIntyre
NDBT inhibition or knockdown increases the intracellular pH gradients, and doxycycline does not reduce the growth of U87 shCTL xenografts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136df8db497a09d60bced4b6b514aa3f
https://doi.org/10.1158/0008-5472.22407755.v1
https://doi.org/10.1158/0008-5472.22407755.v1
Autor:
Reinhard Zeidler, Elisabeth Kremmer, Pawel Swietach, Jian Ping Jen, Alzbeta Hulikova, Josef Mysliwietz, Gabor Gondi
PDF file, 299K, Figure S1 shows the homogenous GFP expression of the A549 single cell clone used for the in vivo experiments. Figure S2 illustrates the distribution of the labeled 6A10 antibody and compares it to the localization of the xenografts. F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a8953e9682f54deefc2d53c4de098bd
https://doi.org/10.1158/0008-5472.22396256
https://doi.org/10.1158/0008-5472.22396256
Autor:
Jaromir Pastorek, Silvia Pastorekova, Claudiu T. Supuran, Juraj Kopacek, Lucia Csaderova, Miriam Zatovicova, Anna Ohradanova-Repic, Alzbeta Hulikova, Eliska Svastova, Franck Dequiedt, Peter Ditte
PDf file - 1.2MB, CA IX co-localization with NBC1 in A549 cells is presented in the form of Z-stack corresponding to Figure 6B.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f6d051d272241a033f41f30b324275
https://doi.org/10.1158/0008-5472.22390074
https://doi.org/10.1158/0008-5472.22390074