Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Alyza Skaist"'
Autor:
Laura A. Sena, Rajendra Kumar, David E. Sanin, Elizabeth A. Thompson, D. Marc Rosen, Susan L. Dalrymple, Lizamma Antony, Yuhan Yang, Carolina Gomes-Alexandre, Jessica L. Hicks, Tracy Jones, Kiara A. Bowers, Jillian N. Eskra, Jennifer Meyers, Anuj Gupta, Alyza Skaist, Srinivasan Yegnasubramanian, Jun Luo, W. Nathaniel Brennen, Sushant K. Kachhap, Emmanuel S. Antonarakis, Angelo M. De Marzo, John T. Isaacs, Mark C. Markowski, Samuel R. Denmeade
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 23 (2022)
Testosterone is the canonical growth factor of prostate cancer but can paradoxically suppress its growth when present at supraphysiological levels. We have previously demonstrated that the cyclical administration of supraphysiological androgen (SPA),
Externí odkaz:
https://doaj.org/article/1190b8e3606d4217ab6c491c95462033
Autor:
Selina Shiqing K. Teh, Kirsten Bowland, Alexis Bennett, Eitan Halper-Stromberg, Alyza Skaist, Aparna Pallavajjala, Jacqueline Tang, Fidel Cai, Antonella Macoretta, Hong Liang, Sarah Wheelan, Ming-Tseh Lin, Ralph H. Hruban, Robert B. Scharpf, Nicholas J. Roberts, James R. Eshleman
Publikováno v:
bioRxiv
Somatic mutations in malignant cells genetically distinguish malignant cells from normal cells. We attempted to determine the type of somatic mutation in cancers that would create the largest number of novel CRISPR-Cas9 target sites. Whole genome seq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa413f1c2c6b3e2b399975f964a890e2
https://doi.org/10.1101/2023.04.15.537042
https://doi.org/10.1101/2023.04.15.537042
Autor:
Selina Shiqing K. Teh, Eitan Halper-Stromberg, Laura Morsberger, Alexis Bennett, Kirsten Bowland, Alyza Skaist, Fidel Cai, Hong Liang, Ralph H. Hruban, Nicholas J. Roberts, Robert B. Scharpf, Ying S. Zou, James R. Eshleman
When we transduced pancreatic cancers with sgRNAs that targeted 2-16 target sites in the human genome, we found that increasing the number of CRISPR-Cas9 target sites produced greater cytotoxicity, with >99% growth inhibition observed by targeting on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfce08e6990151926d1c1b26d9d04f01
https://doi.org/10.1101/2023.04.03.535384
https://doi.org/10.1101/2023.04.03.535384
Autor:
Evanthia T. Roussos Torres, Elana J. Fertig, Elizabeth M. Jaffee, Luciane T. Kagohara, Daria A. Gaykalova, Roisin M. Connolly, Vered Stearns, Srinivasan Yegnasubramanian, Min Yu, Sathish Kumar Ganesan, Sarah J. Wheelan, Michael Considine, Alyza Skaist, Anuj Gupta, Ajay Vaghasia, Emma Bigelow, Gaurav Sharma, Emily F. Davis-Marcisak, Valerie H. Narumi, Brian J. Christmas, Edgar Gonzalez, Aaron G. Baugh, Sofi Castanon, Julie K. Jang, Christine I. Rafie, Dimitrios N. Sidiropoulos
Supplementary Data from Entinostat Decreases Immune Suppression to Promote Antitumor Responses in a HER2+ Breast Tumor Microenvironment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e28169c16cf94af543790c359b314a
https://doi.org/10.1158/2326-6066.22544265.v1
https://doi.org/10.1158/2326-6066.22544265.v1
Autor:
Srinivasan Yegnasubramanian, William G. Nelson, Sarah J. Wheelan, William B. Isaacs, Christina DeStefano Shields, Jianfeng Xu, S. Lilly Zheng, Michael C. Haffner, Jonathan B. Coulter, McKinzie A. Garrison, Alyza Skaist, Ajay Vaghasia, Harshath Gupta, Anuj Gupta, Minh-Tam Pham
Supplementary Figure from Identifying Phased Mutations and Complex Rearrangements in Human Prostate Cancer Cell Lines through Linked-Read Whole-Genome Sequencing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f74e0f528f0b44e595a4a686d003dd6
https://doi.org/10.1158/1541-7786.22528140
https://doi.org/10.1158/1541-7786.22528140
Autor:
Srinivasan Yegnasubramanian, William G. Nelson, Sarah J. Wheelan, William B. Isaacs, Christina DeStefano Shields, Jianfeng Xu, S. Lilly Zheng, Michael C. Haffner, Jonathan B. Coulter, McKinzie A. Garrison, Alyza Skaist, Ajay Vaghasia, Harshath Gupta, Anuj Gupta, Minh-Tam Pham
Supplementary Data from Identifying Phased Mutations and Complex Rearrangements in Human Prostate Cancer Cell Lines through Linked-Read Whole-Genome Sequencing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::079fa3355e6e7a7e7440b04c149268c2
https://doi.org/10.1158/1541-7786.22528146
https://doi.org/10.1158/1541-7786.22528146
Autor:
Srinivasan Yegnasubramanian, William G. Nelson, Sarah J. Wheelan, William B. Isaacs, Christina DeStefano Shields, Jianfeng Xu, S. Lilly Zheng, Michael C. Haffner, Jonathan B. Coulter, McKinzie A. Garrison, Alyza Skaist, Ajay Vaghasia, Harshath Gupta, Anuj Gupta, Minh-Tam Pham
A limited number of cell lines have fueled the majority of preclinical prostate cancer research, but their genomes remain incompletely characterized. Here, we utilized whole-genome linked-read sequencing for comprehensive characterization of phased m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b27371dbf32222e2f7eb6c3686846b7
https://doi.org/10.1158/1541-7786.c.6545628.v1
https://doi.org/10.1158/1541-7786.c.6545628.v1
Autor:
Mindy K. Graham, Roshan Chikarmane, Rulin Wang, Ajay Vaghasia, Anuj Gupta, Qizhi Zheng, Bulouere Wodu, Xin Pan, Nicole Castagna, Jianyong Liu, Jennifer Meyers, Alyza Skaist, Sarah Wheelan, Brian W. Simons, Charles Bieberich, William G. Nelson, Theodore L. DeWeese, Angelo M. De Marzo, Srinivasan Yegnasubramanian
Publikováno v:
The Prostate. 83
Publikováno v:
Molecular Cancer Research. 21:B024-B024
Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma of childhood, and RAS pathway mutations are the known driver mutations in the majority of fusion-negative (FN) RMS. Studies have demonstrated that HRAS mutations are enriched in infants wi
Autor:
Dimitrios N. Sidiropoulos, Christine I. Rafie, Julie K. Jang, Sofi Castanon, Aaron G. Baugh, Edgar Gonzalez, Brian J. Christmas, Valerie H. Narumi, Emily F. Davis-Marcisak, Gaurav Sharma, Emma Bigelow, Ajay Vaghasia, Anuj Gupta, Alyza Skaist, Michael Considine, Sarah J. Wheelan, Sathish Kumar Ganesan, Min Yu, Srinivasan Yegnasubramanian, Vered Stearns, Roisin M. Connolly, Daria A. Gaykalova, Luciane T. Kagohara, Elizabeth M. Jaffee, Elana J. Fertig, Evanthia T. Roussos Torres
Publikováno v:
Cancer Immunol Res
Therapeutic combinations to alter immunosuppressive, solid tumor microenvironments (TME), such as in breast cancer, are essential to improve responses to immune checkpoint inhibitors (ICI). Entinostat, an oral histone deacetylase inhibitor, has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d88480e204678bd21971d978c6a6698d
https://hdl.handle.net/10468/13332
https://hdl.handle.net/10468/13332