Zobrazeno 1 - 10
of 270
pro vyhledávání: '"Alysson R. Muotri"'
Autor:
Shivani Shukla, Joshua L. Schwartz, Callum Walsh, Wen Mai Wong, Vrund Patel, Yu-Peng Hsieh, Chichi Onwuasoanya, Shaoming Chen, Andreas Offenhäusser, Gert Cauwenberghs, Francesca Santoro, Alysson R. Muotri, Gene W. Yeo, Sreekanth H. Chalasani, Zeinab Jahed
Publikováno v:
Microsystems & Nanoengineering, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract The brain integrates activity across networks of interconnected neurons to generate behavioral outputs. Several physiological and imaging-based approaches have been previously used to monitor responses of individual neurons. While these tech
Externí odkaz:
https://doaj.org/article/b8bc8123d45b4d64a93b9b91cebbb8d5
Autor:
Eric Courchesne, Vani Taluja, Sanaz Nazari, Caitlin M. Aamodt, Karen Pierce, Kuaikuai Duan, Sunny Stophaeros, Linda Lopez, Cynthia Carter Barnes, Jaden Troxel, Kathleen Campbell, Tianyun Wang, Kendra Hoekzema, Evan E. Eichler, Joao V. Nani, Wirla Pontes, Sandra Sanchez Sanchez, Michael V. Lombardo, Janaina S. de Souza, Mirian A. F. Hayashi, Alysson R. Muotri
Publikováno v:
Molecular Autism, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Background Social affective and communication symptoms are central to autism spectrum disorder (ASD), yet their severity differs across toddlers: Some toddlers with ASD display improving abilities across early ages and develop good social an
Externí odkaz:
https://doaj.org/article/428ca825209e4345a0da67a2ab8b0da8
Autor:
Hyeon‐Yeol Cho, Myungsik Yoo, Thanapat Pongkulapa, Hudifah Rabie, Alysson R. Muotri, Perry T. Yin, Jeong‐Woo Choi, Ki‐Bum Lee
Publikováno v:
Advanced Science, Vol 11, Iss 24, Pp n/a-n/a (2024)
Abstract The CRISPR‐Cas9 technology has the potential to revolutionize the treatment of various diseases, including Rett syndrome, by enabling the correction of genes or mutations in human patient cells. However, several challenges need to be addre
Externí odkaz:
https://doaj.org/article/7124b7eb05c34190b1e27d9c94807b25
Autor:
Tianyi Chen, Youngser Park, Ali Saad-Eldin, Zachary Lubberts, Avanti Athreya, Benjamin D. Pedigo, Joshua T. Vogelstein, Francesca Puppo, Gabriel A. Silva, Alysson R. Muotri, Weiwei Yang, Christopher M. White, Carey E. Priebe
Publikováno v:
Applied Network Science, Vol 8, Iss 1, Pp 1-13 (2023)
Abstract Recent advancements have been made in the development of cell-based in-vitro neuronal networks, or organoids. In order to better understand the network structure of these organoids, a super-selective algorithm has been proposed for inferring
Externí odkaz:
https://doaj.org/article/dd431d1a9d754a39a8e3c7919c7480ff
Autor:
Jason W. Adams, Annabelle Vinokur, Janaína S. de Souza, Charles Austria, Bruno S. Guerra, Roberto H. Herai, Karl J. Wahlin, Alysson R. Muotri
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113867- (2024)
Summary: Individuals with Williams syndrome (WS), a neurodevelopmental disorder caused by hemizygous loss of 26–28 genes at 7q11.23, characteristically portray a hypersocial phenotype. Copy-number variations and mutations in one of these genes, GTF
Externí odkaz:
https://doaj.org/article/77e344c08eb6407895cdd8d2439e33a3
Autor:
Madison N. Wilson, Martin Thunemann, Xin Liu, Yichen Lu, Francesca Puppo, Jason W. Adams, Jeong-Hoon Kim, Mehrdad Ramezani, Donald P. Pizzo, Srdjan Djurovic, Ole A. Andreassen, Abed AlFatah Mansour, Fred H. Gage, Alysson R. Muotri, Anna Devor, Duygu Kuzum
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Neuronal organoids derived from human induced pluripotent stem cells can be transplanted and integrated into the rodent cortex for the study of brain development and function. Here the authors demonstrate use of transparent graphene microelectrodes a
Externí odkaz:
https://doaj.org/article/43225109ef62426dbfb9593348738fe7
Autor:
Rebecca S. F. Mok, Wenbo Zhang, Taimoor I. Sheikh, Kartik Pradeepan, Isabella R. Fernandes, Leah C. DeJong, Gabriel Benigno, Matthew R. Hildebrandt, Marat Mufteev, Deivid C. Rodrigues, Wei Wei, Alina Piekna, Jiajie Liu, Alysson R. Muotri, John B. Vincent, Lyle Muller, Julio Martinez-Trujillo, Michael W. Salter, James Ellis
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Rett syndrome (RTT) is a severe neurodevelopmental disorder primarily caused by heterozygous loss-of-function mutations in the X-linked gene MECP2 that is a global transcriptional regulator. Mutations in the methyl-CpG binding domain (MBD) o
Externí odkaz:
https://doaj.org/article/d539f76d9ee84f05a36dd38c22599078
Autor:
Érico Moreto Lins, Natássia Cristina Martins Oliveira, Osvaldo Reis, Adriano Ferrasa, Roberto Herai, Alysson R. Muotri, Katlin Brauer Massirer, Mário Henrique Bengtson
Publikováno v:
Molecular Brain, Vol 15, Iss 1, Pp 1-15 (2022)
Abstract During neuronal differentiation, neuroprogenitor cells become polarized, change shape, extend axons, and form complex dendritic trees. While growing, axons are guided by molecular cues to their final destination, where they establish synapti
Externí odkaz:
https://doaj.org/article/53762944a11640f49c68645d6e5c6cc2
Autor:
Fabio Papes, Antonio P. Camargo, Janaina S. de Souza, Vinicius M. A. Carvalho, Ryan A. Szeto, Erin LaMontagne, José R. Teixeira, Simoni H. Avansini, Sandra M. Sánchez-Sánchez, Thiago S. Nakahara, Carolina N. Santo, Wei Wu, Hang Yao, Barbara M. P. Araújo, Paulo E. N. F. Velho, Gabriel G. Haddad, Alysson R. Muotri
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-26 (2022)
Abstract Transcription Factor 4 (TCF4) has been associated with autism, schizophrenia, and other neuropsychiatric disorders. However, how pathological TCF4 mutations affect the human neural tissue is poorly understood. Here, we derive neural progenit
Externí odkaz:
https://doaj.org/article/7f4c4866201a4b0fb0158c28268eed74
Autor:
Itzy E. Morales Pantoja, Lena Smirnova, Alysson R. Muotri, Karl J. Wahlin, Jeffrey Kahn, J. Lomax Boyd, David H. Gracias, Timothy D. Harris, Tzahi Cohen-Karni, Brian S. Caffo, Alexander S. Szalay, Fang Han, Donald J. Zack, Ralph Etienne-Cummings, Akwasi Akwaboah, July Carolina Romero, Dowlette-Mary Alam El Din, Jesse D. Plotkin, Barton L. Paulhamus, Erik C. Johnson, Frederic Gilbert, J. Lowry Curley, Ben Cappiello, Jens C. Schwamborn, Eric J. Hill, Paul Roach, Daniel Tornero, Caroline Krall, Rheinallt Parri, Fenna Sillé, Andre Levchenko, Rabih E. Jabbour, Brett J. Kagan, Cynthia A. Berlinicke, Qi Huang, Alexandra Maertens, Kathrin Herrmann, Katya Tsaioun, Raha Dastgheyb, Christa Whelan Habela, Joshua T. Vogelstein, Thomas Hartung
Publikováno v:
Frontiers in Artificial Intelligence, Vol 6 (2023)
The brain is arguably the most powerful computation system known. It is extremely efficient in processing large amounts of information and can discern signals from noise, adapt, and filter faulty information all while running on only 20 watts of powe
Externí odkaz:
https://doaj.org/article/aebc0f0cd878418ebed9205a612b1932