Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Alyssa Schami"'
Autor:
Colwyn A. Headley, Shalini Gautam, Angelica Olmo‐Fontanez, Andreu Garcia‐Vilanova, Varun Dwivedi, Alyssa Schami, Susan Weintraub, Philip S. Tsao, Jordi B. Torrelles, Joanne Turner
Publikováno v:
Advanced Science, Vol 11, Iss 36, Pp n/a-n/a (2024)
Abstract Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb), is a major global health concern, particularly affecting those with weakened immune systems, including the elderly. CD4+ T cell response is crucial for immunity against M.tb, bu
Externí odkaz:
https://doaj.org/article/0dd086a82df94a179d0e656b797beb92
Autor:
Colwyn A. Headley, Shalini Gautam, Angelica Olmo‐Fontanez, Andreu Garcia‐Vilanova, Varun Dwivedi, Anwari Akhter, Alyssa Schami, Kevin Chiem, Russell Ault, Hao Zhang, Hong Cai, Alison Whigham, Jennifer Delgado, Amberlee Hicks, Philip S. Tsao, Jonathan Gelfond, Luis Martinez‐Sobrido, Yufeng Wang, Jordi B. Torrelles, Joanne Turner
Publikováno v:
Advanced Science, Vol 11, Iss 5, Pp n/a-n/a (2024)
Abstract Mitochondrial dysfunction alters cellular metabolism, increases tissue oxidative stress, and may be principal to the dysregulated signaling and function of CD4+ T lymphocytes in the elderly. In this proof of principle study, it is investigat
Externí odkaz:
https://doaj.org/article/155b08ee8fdd4021bcf7f433c2bfd1c0
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
In the past few decades, drug-resistant (DR) strains of Mycobacterium tuberculosis (M.tb), the causative agent of tuberculosis (TB), have become increasingly prevalent and pose a threat to worldwide public health. These strains range from multi (MDR)
Externí odkaz:
https://doaj.org/article/955ec4360fcd4a1b91e395dd115a0479
Autor:
Kizil A. Yusoof, Juan Ignacio García, Alyssa Schami, Andreu Garcia-Vilanova, Holden V. Kelley, Shu-Hua Wang, Adrian Rendon, Blanca I. Restrepo, Marcel Yotebieng, Jordi B. Torrelles
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Tuberculosis (TB), considered an ancient disease, is still killing one person every 21 seconds. Diagnosis of Mycobacterium tuberculosis (M.tb) still has many challenges, especially in low and middle-income countries with high burden disease rates. Ov
Externí odkaz:
https://doaj.org/article/138b4b2d7ffd42c08d703c71b2385546
Autor:
Fatai S. Oladunni, Jun-Gyu Park, Paula A. Pino, Olga Gonzalez, Anwari Akhter, Anna Allué-Guardia, Angélica Olmo-Fontánez, Shalini Gautam, Andreu Garcia-Vilanova, Chengjin Ye, Kevin Chiem, Colwyn Headley, Varun Dwivedi, Laura M. Parodi, Kendra J. Alfson, Hilary M. Staples, Alyssa Schami, Juan I. Garcia, Alison Whigham, Roy Neal Platt, Michal Gazi, Jesse Martinez, Colin Chuba, Stephanie Earley, Oscar H. Rodriguez, Stephanie Davis Mdaki, Katrina N. Kavelish, Renee Escalona, Cory R. A. Hallam, Corbett Christie, Jean L. Patterson, Tim J. C. Anderson, Ricardo Carrion, Edward J. Dick, Shannan Hall-Ursone, Larry S. Schlesinger, Xavier Alvarez, Deepak Kaushal, Luis D. Giavedoni, Joanne Turner, Luis Martinez-Sobrido, Jordi B. Torrelles
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Here, the authors characterize tissue-level SARS-CoV-2 infection and pathogenesis in transgenic mice expressing human angiotensin converting enzyme 2 (hACE2) by the human cytokeratin 18 promoter (K18-hACE2) and show that infection induces lethality,
Externí odkaz:
https://doaj.org/article/36d6d32972464a4aafa1c9bc19844493
Autor:
Srikarthika Jambunathan, Alyssa Schami, Satinder K. Gidda, Olga Yurchenko, Vishwajeet Puri, Robert T. Mullen, John M. Dyer, Christopher N. James, Ann Price, Kent D. Chapman, Nathan M. Doner
Publikováno v:
Biochimie. 169:41-53
Fat-Specific Protein 27 (FSP27) belongs to a small group of vertebrate proteins containing a Cell-death Inducing DNA fragmentation factor-α-like Effector (CIDE)-C domain and is involved in lipid droplet (LD) accumulation and energy homeostasis. FSP2
Autor:
Alyssa Schami, Wei Ke, Anna Allué-Guardia, Angélica M. Olmo-Fontánez, John Chan, Jordi B. Torrelles
Publikováno v:
The Journal of Immunology. 208:58.19-58.19
Mycobacterium tuberculosis (M.tb), the causative agent of tuberculosis (TB), has a complex cell envelope that provides a barrier of protection to various environments. Peripheral lipids on the M.tb cell envelope act as virulent factors influencing th
Autor:
Colwyn A. Headley, Shalini Gautam, Angelica Olmo-Fontanez, Andreu Garcia-Vilanova, Varun Dwivedi, Anwari Akhter, Alyssa Schami, Kevin Chiem, Russell Ault, Hao Zhang, Hong Cai, Alison Whigham, Jennifer Delgado, Amberlee Hicks, Philip S. Tsao, Jonathan Gelfond, Luis Martinez-Sobrido, Yufeng Wang, Jordi B. Torrelles, Joanne Turner
Mitochondrial dysfunction alters cellular metabolism, increases tissue oxidative stress, and may be principal to the dysregulated signaling and function of CD4+T lymphocytes in the elderly. In this proof of principle study, we investigated whether th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c04c5a07a4ce5fbf92f9c135d70ddda
https://doi.org/10.1101/2021.02.21.432151
https://doi.org/10.1101/2021.02.21.432151
Autor:
Justin Ferdin, Vida L. Hodara, Dhiraj Kumar Singh, Shalini Gautam, Shabaana A. Khader, Shannan Hall-Ursone, Shashank Ganatra, Yenny Goez-Gazi, Tae-Hyung Lee, Benjamin Klaffke, Riti Sharan, Elizabeth Clemmons, Cynthia Alvarez, Olga Gonzalez, Christopher H. Chen, Kathleen M. Brasky, Laura M. Parodi, Kendra J. Alfson, Rajesh Thippeshappa, Alyssa Schami, Joanne Turner, Richard Copin, Andra K. Voges, Angélica Olmo-Fontánez, Makedonka Mitreva, Michal Gazi, Amanda Mannino, Patrice A. Frost, Ruby Escobedo, Alyssa Blakley, Deepak Kaushal, Edward J. Dick, Julia M. Scordo, Dharani Ajithdoss, John Dutton, Journey Cole, Hilary M. Staples, Christos A. Kyratsous, Priscilla Escareno, Luis D. Giavedoni, Ricardo Carrion, Bruce A. Rosa, Maya Gough, Luis Martinez-Sobrido, Mushtaq Ahmed, Bindu Singh, Roy N. Platt, Cory R. A. Hallam, Ken Sayers, Jessica Callery, Jordi B. Torrelles, Adelekan Oyejide, Jean L. Patterson, Andreu G. Vilanova, Carmen Bartley, Tim J. Anderson, Xavier Alvarez, Anna Goodroe, Larry S. Schlesinger, Corinna N. Ross, Alina Baum, Ayan Chatterjee
Publikováno v:
Nature Microbiology
Non-human primate models will expedite therapeutics and vaccines for coronavirus disease 2019 (COVID-19) to clinical trials. Here, we compare acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in young and old rhesus macaque
Autor:
Andreu Garcia-Vilanova, Corbett Christie, Edward J. Dick, Jordi B. Torrelles, Hilary M. Staples, Kendra J. Alfson, Luis D. Giavedoni, Jun-Gyu Park, Tim J. Anderson, Kevin Chiem, Olga Gonzalez, Juan Ignacio García, Larry S. Schlesinger, Laura M. Parodi, Jean L. Patterson, Varun Dwivedi, Deepak Kaushal, Shannan Hall-Ursone, Colin Chuba, Ricardo Carrion, Chengjin Ye, Katrina N. Kavelish, Angélica Olmo-Fontánez, Stephanie Earley, Luis Martinez-Sobrido, Xavier Alvarez, Cory R. A. Hallam, Stephanie Davis Mdaki, Anna Allué-Guardia, Roy N. Platt, Renee Escalona, Paula A. Pino, Alyssa Schami, Colwyn A. Headley, Michal Gazi, Jesse Martinez, Shalini Gautam, Oscar H. Rodriguez, Fatai S. Oladunni, Joanne Turner, Alison Whigham, Anwari Akhter
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Vaccine and antiviral development against SARS-CoV-2 infection or COVID-19 disease would benefit from validated small animal models. Here, we show that transgenic mice expressing human angiotensin-converting enzyme 2 (hACE2) by the human cytokeratin