Výsledky vyhledávání - "Alyssa L O'Green"

SM04755, a small-molecule inhibitor of the Wnt pathway, as a potential topical treatment for tendinopathy

Autor: T. Seo, Kevin Chiu, Dellamary Luis A, S. Kennedy, Maureen Ibanez, Joshua Stewart, Charlene F. Barroga, Abdullah Ghias, Yusuf Yazici, J. Tambiah, Brian Joseph Hofilena, Sunil Kumar Kc, John Hood, V. Deshmukh, Alyssa L O'Green

Publikováno v: Journal of Orthopaedic Research

The Wnt pathway is upregulated in tendinopathy, affecting inflammation and tenocyte differentiation. Given its potential role in tendinopathy, this signaling pathway may be a relevant target for treatment. The current study examined the therapeutic p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a08aec526bfe683a767a1757a5aed705
https://pubmed.ncbi.nlm.nih.gov/33104243

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OP0072 INHIBITION OF CLK2 AND DYRK1A BY SM04690 AS A NOVEL MOLECULAR REGULATOR OF WNT SIGNALING, CHONDROGENESIS, AND INFLAMMATION, A POTENTIAL DISEASE-MODIFYING TREATMENT FOR KNEE OSTEOARTHRITIS

Autor: T. Seo, Alyssa L O'Green, Abdullah Ghias, Melinda Pedraza, Maureen Ibanez, V. Deshmukh, Long Do, Yusuf Yazici, Kevin Chiu, Shawn Cho, Carine Bossard, Joseph Cahiwat, Lisa Lamangan, Carolyn Lai

Publikováno v: Oral Presentations.

Background In the synovial joint, Wnt pathway upregulation contributes to osteoarthritis (OA) by increasing osteocyte differentiation, cartilage thinning, and inflammation. SM04690, a novel small molecule, has previously demonstrated potential OA dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b53a54c595df69929b3408cadfe2da42
https://doi.org/10.1136/annrheumdis-2019-eular.5202

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THU0056 SM04755, A POTENTIAL DISEASE-MODIFYING TREATMENT FOR TENDINOPATHY, MODULATES THE WNT PATHWAY VIA INHIBITION OF CLKS AND DYRK1A

Autor: Alyssa L O'Green, T. Seo, Yusuf Yazici, V. Deshmukh

Publikováno v: Annals of the Rheumatic Diseases. 79:239.2-240

Background:Tendinopathy is an inflammatory and degenerative disorder of tendons caused by injuries and/or overuse. Left untreated, tendinopathy can lead to pain and rupture. Current therapeutic options only treat symptoms. Stem cell- and growth facto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::95a7d170855131b4913492dccaf9ed98
https://doi.org/10.1136/annrheumdis-2020-eular.6625

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