Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Alyssa J. Cozzo"'
Autor:
Alyssa N. Ho, Violet A. Kiesel, Claire E. Gates, Bennett H. Brosnan, Scott P. Connelly, Elaine M. Glenny, Alyssa J. Cozzo, Stephen D. Hursting, Michael Francis Coleman
Publikováno v:
Cells, Vol 13, Iss 10, p 806 (2024)
Triple-negative breast cancer (TNBC) lacks targeted therapies, leaving cytotoxic chemotherapy as the current standard treatment. However, chemotherapy resistance remains a major clinical challenge. Increased insulin-like growth factor 1 signaling can
Externí odkaz:
https://doaj.org/article/1ec0970c8673497f8d4cd59562421e0f
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Every cancer genome is unique, resulting in potentially near infinite cancer cell phenotypes and an inability to predict clinical outcomes in most cases. Despite this profound genomic heterogeneity, many cancer types and subtypes display a non-random
Externí odkaz:
https://doaj.org/article/4ca83b39aba34351bf682af1398ec6e7
Autor:
Laura A. Smith, Dalton M. Craven, Magdalena A. Rainey, Alyssa J. Cozzo, Meredith S. Carson, Elaine M. Glenny, Nishita Sheth, Shannon B. McDonell, Erika T. Rezeli, Stephanie A. Montgomery, Laura W. Bowers, Michael F. Coleman, Stephen D. Hursting
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
IntroductionAdvanced age and obesity are independent risk and progression factors for triple negative breast cancer (TNBC), which presents significant public health concerns for the aging population and its increasing burden of obesity. Due to parall
Externí odkaz:
https://doaj.org/article/d64cde964e82441388b949a28f6acbea
Autor:
Alyssa J. Cozzo, Michael F. Coleman, Jane B. Pearce, Alexander J. Pfeil, Suhas K. Etigunta, Stephen D. Hursting
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Cancer cells experience unique and dynamic shifts in their metabolic function in order to survive, proliferate, and evade growth inhibition in the resource-scarce tumor microenvironment. Therefore, identification of pharmacological agents with potent
Externí odkaz:
https://doaj.org/article/2ac4f3f3b8f14dae888fa5086ffff01e
Autor:
Amy R. Johnson, Yuanyuan Qin, Alyssa J. Cozzo, Alex J. Freemerman, Megan J. Huang, Liyang Zhao, Brante P. Sampey, J. Justin Milner, Melinda A. Beck, Blossom Damania, Naim Rashid, Joseph A. Galanko, Douglas P. Lee, Matthew L. Edin, Darryl C. Zeldin, Patrick T. Fueger, Brittney Dietz, Andreas Stahl, Ying Wu, Karen L. Mohlke, Liza Makowski
Publikováno v:
Molecular Metabolism, Vol 5, Iss 7, Pp 506-526 (2016)
Objective: A novel approach to regulate obesity-associated adipose inflammation may be through metabolic reprogramming of macrophages (MΦs). Broadly speaking, MΦs dependent on glucose are pro-inflammatory, classically activated MΦs (CAM), which co
Externí odkaz:
https://doaj.org/article/3500912ba36c44dabe717f2ead379674
Autor:
Juan Liu, Amy R. Johnson, Ajeeth K. Pingili, Liyang Zhao, Liza Makowski, Joseph A. Galanko, E. Dale Abel, Melinda A. Beck, Heather S. Smallwood, Jeffrey C. Rathmell, Douglas P. Lee, Maili F. Lim, Alyssa J. Cozzo, Bin Teng, Ashley M. Fuller, Brian J. Bennett, Lavanya Bezavada, J. Justin Milner, Jeremy D. Rotty, Jason W. Locasale, Michelle Puchowicz, Alex J. Freemerman, James E. Bear
Publikováno v:
The Journal of Immunology. 202:1265-1286
Macrophages (MΦs) are heterogeneous and metabolically flexible, with metabolism strongly affecting immune activation. A classic response to proinflammatory activation is increased flux through glycolysis with a downregulation of oxidative metabolism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a82692b896b2c4f61e2ca8c8f4e628f
https://doi.org/10.4049/jimmunol.1800002
https://doi.org/10.4049/jimmunol.1800002
Autor:
Michael F. Coleman, Stephen D. Hursting, Alyssa J. Cozzo, Suhas K. Etigunta, Alexander J. Pfeil
Publikováno v:
Cancers, Vol 12, Iss 852, p 852 (2020)
Cancers
Cancers
Immune checkpoint inhibitor (ICI) therapy has shown extraordinary promise at treating cancers otherwise resistant to treatment. However, for ICI therapy to be effective, it must overcome the metabolic limitations of the tumor microenvironment. Tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ed4dedbc80e9f1d3b5c48b3e487219
https://www.mdpi.com/2072-6694/12/4/852
https://www.mdpi.com/2072-6694/12/4/852
Publikováno v:
Comprehensive Physiology
Solid tumor growth and metastasis require the interaction of tumor cells with the surrounding tissue, leading to a view of tumors as tissue-level phenomena rather than exclusively cell-intrinsic anomalies. Due to the ubiquitous nature of adipose tiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e97944466d10ee7db515816e3211c05b
https://doi.org/10.1002/cphy.c170008
https://doi.org/10.1002/cphy.c170008
Publikováno v:
Cancer Research. 81:2700-2700
Obesity is an established risk factor for several breast cancer (BC) subtypes. Obese BC patients also show poorer response to therapy, increased metastases, and increased mortality. While high levels of inflammation are thought to be a driver for BC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7185e6db9f3c9833b7f601173359af5
https://doi.org/10.1158/1538-7445.am2021-2700
https://doi.org/10.1158/1538-7445.am2021-2700
Autor:
James E. Bear, Alex J. Freemerman, Alyssa J. Cozzo, Amy R. Johnson, Taylor Christensen, Brian J. Bennett, Liza Makowski, Jeremy D. Rotty, Liyang Zhao
Publikováno v:
Atherosclerosis. 266:182-189
Background and aims Altered metabolism is an important regulator of macrophage (MΦ) phenotype, which contributes to inflammatory diseases such as atherosclerosis. Broadly, pro-inflammatory, classically-activated MΦs (CAM) are glycolytic while alter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0108979e7ad30d4fadff492e72b2b0bf
https://doi.org/10.1016/j.atherosclerosis.2017.10.009
https://doi.org/10.1016/j.atherosclerosis.2017.10.009