Integrative Analysis of Cytokine and Lipidomics Datasets Following Mild Traumatic Brain Injury in Rats

Autor: Alexis N. Pulliam, Alyssa F. Pybus, David A. Gaul, Samuel G. Moore, Levi B. Wood, Facundo M. Fernández, Michelle C. LaPlaca

Publikováno v: Metabolites, Vol 14, Iss 3, p 133 (2024)

Traumatic brain injury (TBI) is a significant source of disability in the United States and around the world and may lead to long-lasting cognitive deficits and a decreased quality of life for patients across injury severities. Following the primary

Externí odkaz: https://doaj.org/article/aeea03b3b0b24d62b6e2747b295ee6b3

Low cerebral blood flow is a non-invasive biomarker of neuroinflammation after repetitive mild traumatic brain injury

Autor: Sitara B. Sankar, Alyssa F. Pybus, Amanda Liew, Bharat Sanders, Kajol J. Shah, Levi B. Wood, Erin M. Buckley

Publikováno v: Neurobiology of Disease, Vol 124, Iss , Pp 544-554 (2019)

Previous work has shown that non-invasive optical measurement of low cerebral blood flow (CBF) is an acute biomarker of poor long-term cognitive outcome after repetitive mild traumatic brain injury (rmTBI). Herein, we explore the relationship between

Externí odkaz: https://doaj.org/article/7236c66246e54f41a27930619709ecfe

Multi-transcriptomic analysis points to early organelle dysfunction in human astrocytes in Alzheimer's disease

Autor: Elena Galea, Laura D. Weinstock, Raquel Larramona-Arcas, Alyssa F. Pybus, Lydia Giménez-Llort, Carole Escartin, Levi B. Wood

Publikováno v: Neurobiol Dis
Neurobiology of Disease, Vol 166, Iss, Pp 105655-(2022)
Neurobiology of Disease
Neurobiology of Disease, 2022, 166, pp.105655. ⟨10.1016/j.nbd.2022.105655⟩

International audience; The phenotypic transformation of astrocytes in Alzheimer’s disease (AD) is still not well understood. Recentanalyses based on single-nucleus RNA sequencing of postmortem Alzheimer’s disease (AD) samples are limited bythe l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::661f43cb4a1ab456323ac92b4b8b99a2
https://pubmed.ncbi.nlm.nih.gov/35143967

A feasibility trial of gamma sensory flicker for patients with prodromal Alzheimer's disease

Autor: Levi B. Wood, Jonna K Seppa, James J. Lah, Alyssa F. Pybus, Deqiang Qiu, Kay M Colon-Motas, Qiliang He, Annabelle C. Singer, Allan I. Levey, Cecelia Manzanares, Margaret L. Walker, Svjetlana Miocinovic, Lydia Piendel

Publikováno v: Alzheimer's & Dementia : Translational Research & Clinical Interventions
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 7, Iss 1, Pp n/a-n/a (2021)

Introduction We and collaborators discovered that flickering lights and sound at gamma frequency (40 Hz) reduce Alzheimer's disease (AD) pathology and alter immune cells and signaling in mice. To determine the feasibility of this intervention in huma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::377e2337b3be3388a40bc2a43bcd0c2e
http://europepmc.org/articles/PMC8118113

P2-210: CEREBRAL BLOOD FLOW INVERSELY CORRELATES WITH AMYLOID PATHOLOGY AND NEUROINFLAMMATION AFTER REPETITIVE MILD TRAUMATIC BRAIN INJURY

Autor: Alyssa F. Pybus, Junho Yoo, Amanda Liew, Levi B. Wood, Sitara B. Sankar, Erin M. Buckley, Bharat Sanders

Publikováno v: Alzheimer's & Dementia. 15:P657-P658

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94f7ff481c411bede3b0629456a297b4
https://doi.org/10.1016/j.jalz.2019.06.2617