Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Alyssa Dreffs"'
Autor:
Yunpeng Du, Krzysztof Palczewski, Alyssa Dreffs, David A Antonetti, Chieh Allen Lee, Jie Tang, Timothy S. Kern, Haitao Liu, Henri Leinonen
Publikováno v:
Mol Pharmacol
Molecular pharmacology, vol 100, iss 5
Molecular pharmacology, vol 100, iss 5
We compared monotherapies and combinations of therapies that regulate G-protein coupled receptors (GPCR) with respect to their abilities to inhibit early stages of diabetic retinopathy (DR) in streptozotocin-diabetic mice. Metoprolol (MTP; 0.04-1.0 m
Autor:
Andreia Goncalves, David A. Antonetti, Natalie Hudson, Matthew Campbell, Cheng-mao Lin, Jason M. Keil, Alyssa Dreffs, Sarah Sheskey
Publikováno v:
Diabetes
Diabetic retinopathy is one of the leading causes of vision loss and blindness. Extensive preclinical and clinical evidence exists for both vascular and neuronal pathology. However, the relationship of these changes in the neurovascular unit and impa
Autor:
David A. Antonetti, Xuwen Liu, Alyssa Dreffs, Sumathi Shanmugam, Steven F. Abcouwer, Timothy S. Kern, Cheng-mao Lin
Publikováno v:
Investigative Ophthalmology & Visual Science
Investigative ophthalmology & visual science, vol 61, iss 6
Investigative ophthalmology & visual science, vol 61, iss 6
Purpose Extracellular accumulation of all-trans-retinaldehyde (atRAL), a highly reactive visual cycle intermediate, is toxic to cells of the outer retina and contributes to retinal and macular degenerations. However, the contribution of atRAL to reti
Autor:
David A. Antonetti, E. Aaron Runkle, Alyssa Dreffs, Mónica Díaz-Coránguez, William W. Hauswirth, Thomas W. Gardner, Xuwen Liu, Vince A. Chiodo
Publikováno v:
The American Journal of Pathology. 186:2486-2499
Occludin is a transmembrane tight junction protein that contributes to diverse cellular functions, including control of barrier properties, cell migration, and proliferation. Vascular endothelial growth factor (VEGF) induces phosphorylation of occlud
Autor:
David A. Antonetti, Andrey V Dmitriev, Desmond Henderson, Alyssa Dreffs, Robert A. Linsenmeier
Publikováno v:
Current eye research. 43(7)
PURPOSE: Changes in retinal pH may contribute to a variety of eye diseases. To study the effect of acidosis alone, we induced systemic metabolic acidosis and hypothesized that the retina would respond with altered expression of genes involved in acid
Autor:
Eric S. White, Adam J. Booth, Guanyi Lu, Alyssa Dreffs, D. Keith Bishop, Andrés F. Muro, Sherri C. Wood, Ashley M. Cornett
Publikováno v:
The Journal of Pathology. 226:609-618
Advances in donor matching and immunosuppressive therapies have decreased the prevalence of acute rejection of cardiac grafts; however, chronic rejection remains a significant obstacle for long-term allograft survival. While initiating elements of an
Autor:
Eric S. White, Kevin B. Weiss, Vincent F. Fiore, Jeffrey C. Horowitz, Fernando J. Martinez, Laura E. Niklason, Adam J. Booth, Jessica Tsui, Ryan Hadley, Alyssa Dreffs, Ashley M. Cornett, Bethany B. Moore, Stephanie A. Matthes, Thomas H. Barker
Extracellular matrix (ECM) is a dynamic tissue that contributes to organ integrity and function, and its regulation of cell phenotype is a major aspect of cell biology. However, standard in vitro culture approaches are of unclear physiologic relevanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6787c43722b09f67ce713ee902b39fcc
https://europepmc.org/articles/PMC3530219/
https://europepmc.org/articles/PMC3530219/
Autor:
Cory M. Hogaboam, Rommel Sagana, Alyssa Dreffs, Mei Yan, Eric S. White, Bethany B. Moore, Ling Cheng, Shelley L. Schmidt, Galen B. Toews, Ashley M. Cornett, Adam J. Booth, Vibha N. Lama, Kevin R. Flaherty, Jonathan D. Kurtis, Fernando J. Martinez
Publikováno v:
A95. CUTTING EDGE INSIGHTS TO THE PATHOBIOLOGY OF COPD AND INTERSTITIAL LUNG DISEASE.
Autor:
Rommel Sagana, Jessica Tsui, Alyssa Dreffs, Ashley M. Cornett, Adam J. Booth, Mei Yan, Eric S. White
Publikováno v:
B64. PATHWAYS REGULATING FIBROBLAST GENE EXPRESSION.